{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T06:59:14Z","timestamp":1791874754339,"version":"4.3.4"},"reference-count":26,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2003,6,1]],"date-time":"2003-06-01T00:00:00Z","timestamp":1054425600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2003,6,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Occasional EBV infection of human NK cells may lead to malignant diseases such as naso-pharyngeal NK lymphoma although NK cells do not express CD21, the primary receptor for EBV. Here we show that during early EBV infection in patients, NK cells attacked EBV-infected autologous B cells. In vitro, NK cells activated by conjugation to CD21+ B-EBV cell targets transiently acquired a weak CD21+ phenotype by synaptic transfer of few receptor molecules onto their own membrane. In the presence of viral particles, these ectopic receptors allowed EBV binding to the novel NK cell host. Hence, trans-synaptic acquisition of viral receptor from target cells might constitute an unsuspected mode of infection for otherwise unreachable lymphoid hosts.<\/jats:p>","DOI":"10.4049\/jimmunol.170.12.5993","type":"journal-article","created":{"date-parts":[[2014,4,21]],"date-time":"2014-04-21T18:28:03Z","timestamp":1398104883000},"page":"5993-5998","source":"Crossref","is-referenced-by-count":131,"title":["Acquisition of Viral Receptor by NK Cells Through Immunological Synapse"],"prefix":"10.1093","volume":"170","author":[{"given":"Julie","family":"Tabiasco","sequence":"first","affiliation":[{"name":"De\u0301partement Oncoge\u0301ne\u0300se and Signalisation dans les Cellules He\u0301matopoie\u0301tiques, BP3028 Centre Hospitalier Universitaire Purpan , Toulouse ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alain","family":"Vercellone","sequence":"additional","affiliation":[{"name":"De\u0301partement Oncoge\u0301ne\u0300se and Signalisation dans les Cellules He\u0301matopoie\u0301tiques, BP3028 Centre Hospitalier Universitaire Purpan , Toulouse ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabienne","family":"Meggetto","sequence":"additional","affiliation":[{"name":"De\u0301partement Oncoge\u0301ne\u0300se and Signalisation dans les Cellules He\u0301matopoie\u0301tiques, BP3028 Centre Hospitalier Universitaire Purpan , Toulouse ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denis","family":"Hudrisier","sequence":"additional","affiliation":[{"name":"De\u0301partement d\u2019Immunologie, Center de Physiopathologie de Toulouse Purpan, Unite\u0301 563 de l\u2019Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale, BP3028 Centre Hospitalier Universitaire Purpan , Toulouse ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Brousset","sequence":"additional","affiliation":[{"name":"De\u0301partement Oncoge\u0301ne\u0300se and Signalisation dans les Cellules He\u0301matopoie\u0301tiques, BP3028 Centre Hospitalier Universitaire Purpan , Toulouse ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Jacques","family":"Fournie\u0301","sequence":"additional","affiliation":[{"name":"De\u0301partement Oncoge\u0301ne\u0300se and Signalisation dans les Cellules He\u0301matopoie\u0301tiques, BP3028 Centre Hospitalier Universitaire Purpan , Toulouse ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2003,6,15]]},"reference":[{"key":"2026020210125358900_R1","first-page":"2575","volume-title":"Fields Virology","year":"2001"},{"key":"2026020210125358900_R2","first-page":"203","volume-title":"Cell","year":"1987"},{"key":"2026020210125358900_R3","first-page":"4657","volume-title":"J. Virol.","year":"1997"},{"key":"2026020210125358900_R4","first-page":"5552","volume-title":"J. Virol.","year":"1998"},{"key":"2026020210125358900_R5","first-page":"594","volume-title":"Nat. Med.","year":"2002"},{"key":"2026020210125358900_R6","first-page":"283","volume-title":"Crit. Rev. Oncol. Hematol.","year":"2002"},{"key":"2026020210125358900_R7","first-page":"11139","volume-title":"J. Virol.","year":"2002"},{"key":"2026020210125358900_R8","first-page":"375","volume-title":"Annu. Rev. Immunol.","year":"2001"},{"key":"2026020210125358900_R9","first-page":"489","volume-title":"Nature","year":"2001"},{"key":"2026020210125358900_R10","first-page":"15062","volume-title":"Proc. Natl. Acad. Sci. USA","year":"1999"},{"key":"2026020210125358900_R11","first-page":"1519","volume-title":"J. Exp. Med.","year":"2001"},{"key":"2026020210125358900_R12","first-page":"1507","volume-title":"J. Exp. Med.","year":"2001"},{"key":"2026020210125358900_R13"},{"key":"2026020210125358900_R14","first-page":"477","volume-title":"FASEB J.","year":"2002"},{"key":"2026020210125358900_R15","first-page":"493","volume-title":"Science","year":"1983"},{"key":"2026020210125358900_R16","first-page":"12173","volume-title":"J. Biol. Chem.","year":"1991"},{"key":"2026020210125358900_R17","first-page":"3645","volume-title":"J. Immunol.","year":"2001"},{"key":"2026020210125358900_R18","first-page":"6336","volume-title":"J. Immunol.","year":"2002"},{"key":"2026020210125358900_R19","first-page":"751","volume-title":"Immunity","year":"2001"},{"key":"2026020210125358900_R20","first-page":"513","volume-title":"EMBO J.","year":"2000"},{"key":"2026020210125358900_R21","first-page":"27","volume-title":"Nat. Immunol.","year":"2002"},{"key":"2026020210125358900_R22","first-page":"952","volume-title":"Science","year":"1999"},{"key":"2026020210125358900_R23","first-page":"491","volume-title":"Leuk. Lymphoma","year":"1998"},{"key":"2026020210125358900_R24","first-page":"7015","volume-title":"Proc. Natl. Acad. Sci. USA","year":"2002"},{"key":"2026020210125358900_R25","first-page":"414","volume-title":"Trends Mol. Med.","year":"2002"},{"key":"2026020210125358900_R26","first-page":"1713","volume-title":"Science","year":"2003"}],"container-title":["The Journal of Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/170\/12\/5993\/62570274\/5993.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/170\/12\/5993\/62570274\/5993.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T15:16:41Z","timestamp":1770045401000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jimmunol\/article\/170\/12\/5993\/8028645"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,6]]},"references-count":26,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2003,6,15]]},"published-print":{"date-parts":[[2003,6,15]]}},"URL":"https:\/\/doi.org\/10.4049\/jimmunol.170.12.5993","relation":{},"ISSN":["0022-1767","1550-6606"],"issn-type":[{"value":"0022-1767","type":"print"},{"value":"1550-6606","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2003,6]]},"published":{"date-parts":[[2003,6]]}}}