{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T15:15:31Z","timestamp":1790435731833,"version":"4.1.0"},"reference-count":36,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2003,6,1]],"date-time":"2003-06-01T00:00:00Z","timestamp":1054425600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2003,6,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Abs specific for phosphorylcholine (PC) are known to contribute to the immune defense against a variety of microbial infections. To assess for other types of binding interactions, we performed surveys of anti-PC Abs of diverse biologic origins and structural diversity and demonstrated a common autoreactivity for oxidatively modified low density lipoprotein and other oxidation-specific structures containing PC-Ags. We also found that cells undergoing apoptosis sequentially express a range of oxidation-specific neo-self PC determinants. Whereas natural Abs to PC recognized cells at early stages of apoptosis, by contrast, an IgG anti-PC Ab, representative of a T cell-dependent response, recognized PC determinants primarily associated with late stages of apoptosis. Cumulatively, these results demonstrate a fundamental paradigm in which Abs from both the innate and the T cell-dependent tiers of the B cell compartment recognize a minimal molecular motif arrayed both on microbes and as neo-self Ags linked to atherosclerosis and autoimmune disease.<\/jats:p>","DOI":"10.4049\/jimmunol.170.12.6151","type":"journal-article","created":{"date-parts":[[2014,4,21]],"date-time":"2014-04-21T18:28:03Z","timestamp":1398104883000},"page":"6151-6157","source":"Crossref","is-referenced-by-count":84,"title":["The Autoreactivity of Anti-Phosphorylcholine Antibodies for Atherosclerosis-Associated Neo-Antigens and Apoptotic Cells"],"prefix":"10.1093","volume":"170","author":[{"given":"Peter X","family":"Shaw","sequence":"first","affiliation":[{"name":"Divisions of Endocrinology and Metabolism, University of California San Diego , La Jolla, CA 92093"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carl S","family":"Goodyear","sequence":"additional","affiliation":[{"name":"Divisions of Rheumatology, Allergy and Immunology, Department of Medicine, University of California San Diego , La Jolla, CA 92093"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mi-Kyung","family":"Chang","sequence":"additional","affiliation":[{"name":"Divisions of Endocrinology and Metabolism, University of California San Diego , La Jolla, CA 92093"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph L","family":"Witztum","sequence":"additional","affiliation":[{"name":"Divisions of Endocrinology and Metabolism, University of California San Diego , La Jolla, CA 92093"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregg J","family":"Silverman","sequence":"additional","affiliation":[{"name":"Divisions of Rheumatology, Allergy and Immunology, Department of Medicine, University of California San Diego , La Jolla, CA 92093"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2003,6,15]]},"reference":[{"key":"2026020210141638300_R1","first-page":"793","volume-title":"Nat. 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