{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T21:19:42Z","timestamp":1790630382440,"version":"4.1.0"},"reference-count":50,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2003,1,1]],"date-time":"2003-01-01T00:00:00Z","timestamp":1041379200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2003,1,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>In addition to its established role in innate immune mechanisms, complement component C3 is also of critical importance in B cell activation and T cell-dependent Ab responses. In this study, we have examined the requirement for C3 in the generation of primary CD8 T cell responses to an acute systemic viral infection. We compared Ag-specific CD8 T cell responses to lymphocytic choriomeningitis virus (LCMV) between wild-type (+\/+) and C3-deficient (C3\u2212\/\u2212) mice on both 129\/B6 and B6 backgrounds. These studies revealed that C3 activity is required for optimal expansion of LCMV-specific effector CD8 T cells in an epitope-dependent fashion, which is influenced by the genetic background of the mice. Studies in complement receptor 1\/2 (CR1\/CR2)-deficient mice showed that regulation of LCMV-specific CD8 T cell responses by C3 is not dependent upon CR1\/CR2. These findings may have implications in vaccine development, therapy of autoimmune diseases, and prevention of graft rejection.<\/jats:p>","DOI":"10.4049\/jimmunol.170.2.788","type":"journal-article","created":{"date-parts":[[2014,4,21]],"date-time":"2014-04-21T00:04:08Z","timestamp":1398038648000},"page":"788-794","source":"Crossref","is-referenced-by-count":96,"title":["Complement Component 3 Is Required for Optimal Expansion of CD8 T Cells During a Systemic Viral Infection"],"prefix":"10.1093","volume":"170","author":[{"given":"M","family":"Suresh","sequence":"first","affiliation":[{"name":"Departments of Pathobiological Sciences, University of Wisconsin , Madison, WI 53706"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hector","family":"Molina","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Washington University , St. Louis, MO 63110"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria S","family":"Salvato","sequence":"additional","affiliation":[{"name":"Institute of Human Virology, University of Maryland Biotechnology Institute , Baltimore, MD 21201"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimitrios","family":"Mastellos","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, University of Pennsylvania , Philadelphia, PA 19104"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John D","family":"Lambris","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, University of Pennsylvania , Philadelphia, PA 19104"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matyas","family":"Sandor","sequence":"additional","affiliation":[{"name":"Departments of Laboratory Medicine and Pathology, University of Wisconsin , Madison, WI 53706"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2003,1,15]]},"reference":[{"key":"2025032709205889900_R1","first-page":"346","volume-title":"Nat. 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