{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T03:58:44Z","timestamp":1789876724534,"version":"4.0.1"},"reference-count":49,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2003,1,1]],"date-time":"2003-01-01T00:00:00Z","timestamp":1041379200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2003,1,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Suppressor of cytokine signaling (SOCS)-1 is a member of a family of proteins that negatively regulate cytokine signaling pathways. We have previously established that SOCS-1 is a key regulator of IFN-\u03b3 signaling and that IFN-\u03b3 is responsible for the complex inflammatory disease that leads to the death of SOCS-1-deficient mice. In this study, we provide evidence that SOCS-1 is also a critical regulator of IFN-\u03b3-independent immunoregulatory factors. Mice lacking both SOCS-1 and IFN-\u03b3, although outwardly healthy, have clear abnormalities in their immune system, including a reduced ratio of CD4:CD8 T cells in lymphoid tissues and increased expression of T cell activation markers. To examine the contribution of TCR Ag specificity to these immune defects, we have generated two lines of SOCS-1-deficient mice expressing a transgenic TCR specific for an exogenous Ag, OVA (OT-I and OT-II). Although TCR transgenic SOCS-1\u2212\/\u2212 mice have a longer lifespan than nontransgenic SOCS-1\u2212\/\u2212 mice, they still die as young adults with inflammatory disease and the TCR transgenic SOCS-1\u2212\/\u2212 T cells appear activated despite the absence of OVA. This suggests that both Ag-dependent and -independent mechanisms contribute to the disease in SOCS-1-deficient mice. Thus, SOCS-1 is a critical regulator of T cell activation and homeostasis, and its influence extends beyond regulating IFN-\u03b3 signaling.<\/jats:p>","DOI":"10.4049\/jimmunol.170.2.878","type":"journal-article","created":{"date-parts":[[2014,4,21]],"date-time":"2014-04-21T00:04:08Z","timestamp":1398038648000},"page":"878-886","source":"Crossref","is-referenced-by-count":59,"title":["Suppressor of Cytokine Signaling-1 Has IFN-\u03b3-Independent Actions in T Cell Homeostasis"],"prefix":"10.1093","volume":"170","author":[{"given":"Ann L","family":"Cornish","sequence":"first","affiliation":[{"name":"The Walter and Eliza Hall Institute of Medical Research , Victoria ,","place":["Australia"]},{"name":"Cooperative Research Center for Cellular Growth Factors , Parkville, Victoria ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gayle M","family":"Davey","sequence":"additional","affiliation":[{"name":"The Walter and Eliza Hall Institute of Medical Research , Victoria ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donald","family":"Metcalf","sequence":"additional","affiliation":[{"name":"The Walter and Eliza Hall Institute of Medical Research , Victoria ,","place":["Australia"]},{"name":"Cooperative Research Center for Cellular Growth Factors , Parkville, Victoria ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jared F","family":"Purton","sequence":"additional","affiliation":[{"name":"Department of Pathology and Immunology, Central and Eastern Clinical School, Monash University , Prahran, Victoria ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason E","family":"Corbin","sequence":"additional","affiliation":[{"name":"The Walter and Eliza Hall Institute of Medical Research , Victoria ,","place":["Australia"]},{"name":"Cooperative Research Center for Cellular Growth Factors , Parkville, Victoria ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher J","family":"Greenhalgh","sequence":"additional","affiliation":[{"name":"The Walter and Eliza Hall Institute of Medical Research , Victoria ,","place":["Australia"]},{"name":"Cooperative Research Center for Cellular Growth Factors , Parkville, Victoria ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rima","family":"Darwiche","sequence":"additional","affiliation":[{"name":"The Walter and Eliza Hall Institute of Medical Research , Victoria ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Wu","sequence":"additional","affiliation":[{"name":"The Walter and Eliza Hall Institute of Medical Research , Victoria ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicos A","family":"Nicola","sequence":"additional","affiliation":[{"name":"The Walter and Eliza Hall Institute of Medical Research , Victoria ,","place":["Australia"]},{"name":"Cooperative Research Center for Cellular Growth Factors , Parkville, Victoria ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dale I","family":"Godfrey","sequence":"additional","affiliation":[{"name":"Department of Pathology and Immunology, Central and Eastern Clinical School, Monash University , Prahran, Victoria ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William R","family":"Heath","sequence":"additional","affiliation":[{"name":"The Walter and Eliza Hall Institute of Medical Research , Victoria ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas J","family":"Hilton","sequence":"additional","affiliation":[{"name":"The Walter and Eliza Hall Institute of Medical Research , Victoria ,","place":["Australia"]},{"name":"Cooperative Research Center for Cellular Growth Factors , Parkville, Victoria ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Warren S","family":"Alexander","sequence":"additional","affiliation":[{"name":"The Walter and Eliza Hall Institute of Medical Research , Victoria ,","place":["Australia"]},{"name":"Cooperative Research Center for Cellular Growth Factors , Parkville, Victoria ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robyn","family":"Starr","sequence":"additional","affiliation":[{"name":"The Walter and Eliza Hall Institute of Medical Research , Victoria ,","place":["Australia"]},{"name":"Cooperative Research Center for Cellular Growth Factors , Parkville, Victoria ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2003,1,15]]},"reference":[{"key":"2025032709205760200_R1","first-page":"223","volume-title":"Immunity","year":"1995"},{"key":"2025032709205760200_R2","first-page":"377","volume-title":"Proc. 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