{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T17:11:00Z","timestamp":1791047460046,"version":"4.1.0"},"reference-count":49,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2003,2,1]],"date-time":"2003-02-01T00:00:00Z","timestamp":1044057600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2003,2,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Negative selection is designed to purge the immune system of high-avidity, self-reactive T cells and thereby protect the host from overt autoimmunity. In this in vivo viral infection model, we show that there is a previously unappreciated dichotomy involved in negative selection in which high-avidity CD8+ T cells specific for a dominant epitope are eliminated, whereas T cells specific for a subdominant epitope on the same protein preferentially escape deletion. Although this resulted in significant skewing of immunodominance and a substantial depletion of the most promiscuous T cells, thymic and\/or peripheral deletion of high-avidity CD8+ T cells was not accompanied by any major change in the TCR V\u03b2 gene family usage or an absolute deletion of a single preferred complementarity-determining region 3 length polymorphism. This suggests that negative selection allows high-avidity CD8+ T cells specific for subdominant or cryptic epitopes to persist while effectively deleting high-avidity T cells specific for dominant epitopes. By allowing the escape of subdominant T cells, this process still preserves a relatively broad peripheral TCR repertoire that can actively participate in antiviral and\/or autoreactive immune responses.<\/jats:p>","DOI":"10.4049\/jimmunol.170.3.1231","type":"journal-article","created":{"date-parts":[[2014,4,21]],"date-time":"2014-04-21T23:54:33Z","timestamp":1398124473000},"page":"1231-1239","source":"Crossref","is-referenced-by-count":31,"title":["Preferential Escape of Subdominant CD8+ T Cells During Negative Selection Results in an Altered Antiviral T Cell Hierarchy"],"prefix":"10.1093","volume":"170","author":[{"given":"Mark K","family":"Slifka","sequence":"first","affiliation":[{"name":"Oregon Health and Science University Vaccine and Gene Therapy Institute , Beaverton, OR 97006"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph N","family":"Blattman","sequence":"additional","affiliation":[{"name":"Emory Vaccine Center and Department of Microbiology and Immunology, Emory University School of Medicine , Atlanta, GA 30322"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David J D","family":"Sourdive","sequence":"additional","affiliation":[{"name":"Emory Vaccine Center and Department of Microbiology and Immunology, Emory University School of Medicine , Atlanta, GA 30322"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Liu","sequence":"additional","affiliation":[{"name":"Division of Virology, Department of Neuropharmacology, The Scripps Research Institute , La Jolla, CA 92037"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donald L","family":"Huffman","sequence":"additional","affiliation":[{"name":"Division of Immune Regulation, La Jolla Institute for Allergy and Immunology , San Diego, CA 92121"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tom","family":"Wolfe","sequence":"additional","affiliation":[{"name":"Division of Immune Regulation, La Jolla Institute for Allergy and Immunology , San Diego, CA 92121"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Hughes","sequence":"additional","affiliation":[{"name":"Division of Immune Regulation, La Jolla Institute for Allergy and Immunology , San Diego, CA 92121"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael B A","family":"Oldstone","sequence":"additional","affiliation":[{"name":"Division of Virology, Department of Neuropharmacology, The Scripps Research Institute , La Jolla, CA 92037"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafi","family":"Ahmed","sequence":"additional","affiliation":[{"name":"Emory Vaccine Center and Department of Microbiology and Immunology, Emory University School of Medicine , Atlanta, GA 30322"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias G","family":"von Herrath","sequence":"additional","affiliation":[{"name":"Division of Immune Regulation, La Jolla Institute for Allergy and Immunology , San Diego, CA 92121"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2003,2,1]]},"reference":[{"key":"2026020210033984700_R1","first-page":"651","volume-title":"Cell","year":"1994"},{"key":"2026020210033984700_R2","first-page":"9851","volume-title":"Proc. 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