{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T21:42:53Z","timestamp":1790890973963,"version":"4.1.0"},"reference-count":44,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2003,2,1]],"date-time":"2003-02-01T00:00:00Z","timestamp":1044057600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2003,2,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>A better understanding of the regulatory role of genital tract T cells is much needed. In this study, we have analyzed the phenotype, distribution, and function of T lymphocytes in the female genital tract of naive, pregnant, or Chlamydia trachomatis-infected C57BL\/6 mice. Unexpectedly, we found that the dominant lymphocyte population (70\u201390%) in the genital tract was that of CD3+\u03b1\u03b2TCRintCD4\u2212CD8\u2212 T cells. Moreover, these cells were CD90low but negative for the classical T cell markers CD2 and CD5. The CD3+B220low cells were NK1.1 negative and found in nude mice as well as in mice deficient for MHC class II, \u03b22-microglobulin, and CD1, indicating extrathymic origin. They dominated the KJ126+V\u03b28.2+ population in the genital tract of DO11.10 OVA TCR-transgenic mice, further supporting the idea that the CD3+B220low cells are truly T cells. The function of these T cells appeared not to be associated with immune protection, because only CD4+ and CD8+ T cells increased in the genital tract following chlamydial infection. Notwithstanding this, the infected, as well as the uninfected and the pregnant, uterus was dominated by a high level of the CD3+CD4\u2212CD8\u2212B220low cells. Following in vitro Ag or polyclonal stimulation of the CD3+CD4\u2212CD8\u2212B220low cells, poor proliferative responses were observed. However, these cells strongly impaired splenic T cell proliferation in a cell density-dependent manner. A large fraction of the cells expressed CD25 and produced IFN-\u03b3 upon anti-CD3 plus anti-CD28 stimulation, arguing for a strong regulatory role of this novel T cell population in the mouse female genital tract.<\/jats:p>","DOI":"10.4049\/jimmunol.170.4.1659","type":"journal-article","created":{"date-parts":[[2014,4,21]],"date-time":"2014-04-21T19:49:07Z","timestamp":1398109747000},"page":"1659-1666","source":"Crossref","is-referenced-by-count":56,"title":["A Unique Population of Extrathymically Derived \u03b1\u03b2TCR+CD4\u2212CD8\u2212 T Cells with Regulatory Functions Dominates the Mouse Female Genital Tract"],"prefix":"10.1093","volume":"170","author":[{"given":"Martina","family":"Johansson","sequence":"first","affiliation":[{"name":"Department of Clinical Immunology, University of Go\u0308teborg , Go\u0308teborg ,","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nils","family":"Lycke","sequence":"additional","affiliation":[{"name":"Department of Clinical Immunology, University of Go\u0308teborg , Go\u0308teborg ,","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2003,2,15]]},"reference":[{"key":"2026020210115808800_R1","first-page":"1784","volume-title":"Infect. 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