{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T01:18:41Z","timestamp":1784251121601,"version":"3.55.0"},"reference-count":39,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2003,2,1]],"date-time":"2003-02-01T00:00:00Z","timestamp":1044057600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2003,2,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The onset of allergic inflammation in the lung is driven by a complex genetic program. This study shows that found in inflammatory zone (FIZZ)1 and FIZZ2, but not FIZZ3, gene expression was up-regulated 6 h after Ag challenge in a mouse model of acute pulmonary inflammation. Induction of both genes was abolished in allergen-challenged STAT6-deficient mice. FIZZ1, but not FIZZ2, mRNA was up-regulated upon incubation of the myeloid cell line BMnot with IL-4. The promoter region of FIZZ1 contains functional binding sites for STAT6 and C\/EBP. FIZZ1 promoter reporter gene constructs responded to IL-4 and IL-13 stimulation in transiently transfected cells. Point mutations in the STAT6 or the C\/EBP site led to loss of cytokine responsiveness indicating that IL-4-mediated induction of murine FIZZ1 is orchestrated by the coordinate action of STAT6 and C\/EBP. It is concluded that the expression of the genes encoding FIZZ1 and FIZZ2, but not FIZZ3, is induced in allergen-challenged lungs in a STAT6-dependent fashion. STAT6 directly regulates IL-4- and IL-13-triggered induction of FIZZ1 expression at the transcriptional level by cooperation with C\/EBP. Induction of FIZZ2 gene expression most likely occurs independent of a direct effect by these cytokines and may be due to indirect STAT6-driven mechanisms.<\/jats:p>","DOI":"10.4049\/jimmunol.170.4.1789","type":"journal-article","created":{"date-parts":[[2014,4,21]],"date-time":"2014-04-21T19:49:07Z","timestamp":1398109747000},"page":"1789-1796","source":"Crossref","is-referenced-by-count":102,"title":["The Th2 Cell Cytokines IL-4 and IL-13 Regulate Found in Inflammatory Zone 1\/Resistin-Like Molecule \u03b1 Gene Expression by a STAT6 and CCAAT\/Enhancer-Binding Protein-Dependent Mechanism"],"prefix":"10.1093","volume":"170","author":[{"given":"Adrian M","family":"Stu\u0308tz","sequence":"first","affiliation":[{"name":"Department of Allergic Diseases, Novartis Forschungsinstitut , Vienna ,","place":["Austria"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louise A","family":"Pickart","sequence":"additional","affiliation":[{"name":"Department of Allergic Diseases, Novartis Forschungsinstitut , Vienna ,","place":["Austria"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandre","family":"Trifilieff","sequence":"additional","affiliation":[{"name":"Novartis Respiratory Research Center , Horsham ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Baumruker","sequence":"additional","affiliation":[{"name":"Department of Allergic Diseases, Novartis Forschungsinstitut , Vienna ,","place":["Austria"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Prieschl-Strassmayr","sequence":"additional","affiliation":[{"name":"Department of Allergic Diseases, Novartis Forschungsinstitut , Vienna ,","place":["Austria"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maximilian","family":"Woisetschla\u0308ger","sequence":"additional","affiliation":[{"name":"Department of Allergic Diseases, Novartis Forschungsinstitut , Vienna ,","place":["Austria"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2003,2,15]]},"reference":[{"key":"2026020210073215300_R1","first-page":"466","volume-title":"J. 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