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Reinfection with L. monocytogenes, while inducing explosive proliferation of H2-Kd-restricted T cells, does not stimulate significant expansion of H2-M3-restricted CTL. These disparate responses to reinfection are apparent within 5 days of primary L. monocytogenes infection. However, H2-M3-restricted memory T cells are generated, and are indistinguishable from classically restricted T cells in terms of cell surface memory markers and longevity. Early responses of H2-M3- and H2-Kd-restricted memory T cells to reinfection are similar, with increases in size and expression of activation markers. Interestingly, priming of H2-M3-restricted T cells with an L. monocytogenes-derived N-formyl peptide plus anti-CD40 generates memory T cells that expand upon re-exposure to Ag during L. monocytogenes infection. Our data indicate that disparate H2-M3- and MHC class Ia-restricted memory T cell responses reflect intrinsic differences between these T cell populations. Although distinct proliferative programs appear to be hardwired in these populations during primary L. monocytogenes infection, under different inflammatory circumstances M3-restricted T cell populations can maintain the ability to expand upon re-exposure to Ag.<\/jats:p>","DOI":"10.4049\/jimmunol.170.4.1862","type":"journal-article","created":{"date-parts":[[2014,4,21]],"date-time":"2014-04-21T19:49:07Z","timestamp":1398109747000},"page":"1862-1869","source":"Crossref","is-referenced-by-count":27,"title":["H2-M3-Restricted Memory T Cells: Persistence and Activation Without Expansion"],"prefix":"10.1093","volume":"170","author":[{"given":"Kristen M","family":"Kerksiek","sequence":"first","affiliation":[{"name":"Section of Immunobiology, Yale University School of Medicine , New Haven, CT 06520"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Ploss","sequence":"additional","affiliation":[{"name":"Infectious Diseases Service, Department of Medicine and Laboratory of Antimicrobial Immunity, Immunology Program, Sloan-Kettering Institute, Memorial Sloan-Kettering Cancer Center , New York, NY 10021"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ingrid","family":"Leiner","sequence":"additional","affiliation":[{"name":"Infectious Diseases Service, Department of Medicine and Laboratory of Antimicrobial Immunity, Immunology Program, Sloan-Kettering Institute, Memorial Sloan-Kettering Cancer Center , New York, NY 10021"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dirk H","family":"Busch","sequence":"additional","affiliation":[{"name":"Institut fu\u0308r Mikrobiologie, Immunologie und Hygiene, Technische Universita\u0308t Mu\u0308nchen , Mu\u0308nchen ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric G","family":"Pamer","sequence":"additional","affiliation":[{"name":"Infectious Diseases Service, Department of Medicine and Laboratory of Antimicrobial Immunity, Immunology Program, Sloan-Kettering Institute, Memorial Sloan-Kettering Cancer Center , New York, NY 10021"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2003,2,15]]},"reference":[{"key":"2026020210114078600_R1","first-page":"54","volume-title":"Science","year":"1996"},{"key":"2026020210114078600_R2","first-page":"201","volume-title":"Annu. 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