{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T21:20:29Z","timestamp":1791148829883,"version":"4.1.0"},"reference-count":55,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2003,3,1]],"date-time":"2003-03-01T00:00:00Z","timestamp":1046476800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2003,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The accelerated development of systemic lupus erythematosus (SLE) in BXSB male mice is associated with the presence of an as yet unidentified mutant gene, Yaa (Y-linked autoimmune acceleration). In view of a possible role of marginal zone (MZ) B cells in murine SLE, we have explored whether the expression of the Yaa mutation affects the differentiation of MZ and follicular B cells, thereby implicating the acceleration of the disease. In this study, we show that both BXSB and C57BL\/6 Yaa mice, including two different substrains of BXSB Yaa males that are protected from SLE, displayed an impaired development of MZ B cells early in life. Studies in bone marrow chimeras revealed that the loss of MZ B cells resulted from a defect intrinsic to B cells expressing the Yaa mutation. The lack of selective expansion of MZ B cells in diseased BXSB Yaa males strongly argues against a major role of MZ B cells in the generation of pathogenic autoantibodies in the BXSB model of SLE. Furthermore, a comparative analysis with mice deficient in CD22 or expressing an IgM anti-trinitrophenyl\/DNA transgene suggests that the hyperreactive phenotype of Yaa B cells, as judged by a markedly increased spontaneous IgM secretion, is likely to contribute to the enhanced maturation toward follicular B cells and the block in the MZ B cell generation.<\/jats:p>","DOI":"10.4049\/jimmunol.170.5.2293","type":"journal-article","created":{"date-parts":[[2014,4,20]],"date-time":"2014-04-20T21:32:44Z","timestamp":1398029564000},"page":"2293-2301","source":"Crossref","is-referenced-by-count":61,"title":["The\n                    <i>Yaa<\/i>\n                    Mutation Promoting Murine Lupus Causes Defective Development of Marginal Zone B Cells"],"prefix":"10.1093","volume":"170","author":[{"given":"Hirofumi","family":"Amano","sequence":"first","affiliation":[{"name":"Department of Pathology, University of Geneva , Geneva ,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eri","family":"Amano","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Geneva , Geneva ,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Moll","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Geneva , Geneva ,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dragan","family":"Marinkovic","sequence":"additional","affiliation":[{"name":"Department of Physiological Chemistry, University of Ulm , Ulm ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nabila","family":"Ibnou-Zekri","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Geneva , Geneva ,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo","family":"Martinez-Sori\u0301a","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Geneva , Geneva ,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle","family":"Semac","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Geneva , Geneva ,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Wirth","sequence":"additional","affiliation":[{"name":"Department of Physiological Chemistry, University of Ulm , Ulm ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars","family":"Nitschke","sequence":"additional","affiliation":[{"name":"Institute for Virology and Immunobiology, University of Wu\u0308rzburg , Wu\u0308rzburg ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shozo","family":"Izui","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Geneva , Geneva ,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2003,3,1]]},"reference":[{"key":"2026020210080785000_R1","first-page":"1188","volume-title":"Arthritis Rheum.","year":"1979"},{"key":"2026020210080785000_R2","first-page":"137","volume-title":"Immunol. 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