{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T11:27:48Z","timestamp":1791286068722,"version":"4.1.0"},"reference-count":21,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2003,3,1]],"date-time":"2003-03-01T00:00:00Z","timestamp":1046476800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2003,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The mouse Fc\u03b3RI is one of the most fundamentally important FcRs. It participates in different stages of immunity, being a low affinity receptor for T-independent IgG3 and yet a high affinity receptor for IgG2a, the product of a Th1 immune response. However, analysis of this receptor has been difficult due largely to the failure to generate specific Abs to this FcR. We have made use of the polymorphic differences between BALB\/c and NOD\/Lt mice to generate mAb specific for the Fc\u03b3RI of BALB\/c and the majority of in-bred mouse strains. Three different mAb were obtained that detected Fc\u03b3RI encoded by the more common Fcgr1a and Fcgr1b alleles, and although they identified different epitopes, none inhibited the binding of IgG to Fc\u03b3RI. When bound to Fc\u03b3RI, these mAb induced calcium mobilization upon cross-linking. Several novel observations were made of the cellular distribution of Fc\u03b3RI. Resting and IFN-\u03b3-induced macrophages expressed Fc\u03b3RI as well as mast cell lines. Both bone marrow-derived and freshly isolated dendritic cells from spleen and lymph nodes expressed Fc\u03b3RI. A class of DC, uniquely found in s.c. lymph nodes, expressed the highest level of Fc\u03b3RI and also high levels of MHC class II, DEC205, CD40, and CD86, with a low level of CD8\u03b1, corresponding to the phenotype for Langerhans-derived DC, which are highly active in Ag processing. Thus, in addition to any role in effector functions, Fc\u03b3RI on APC may act as a link between innate and adaptive immunities by binding and mediating the uptake of T-independent immune complexes for presentation, thereby assisting in the development of T-dependent immune responses.<\/jats:p>","DOI":"10.4049\/jimmunol.170.5.2549","type":"journal-article","created":{"date-parts":[[2014,4,20]],"date-time":"2014-04-20T21:32:44Z","timestamp":1398029564000},"page":"2549-2556","source":"Crossref","is-referenced-by-count":39,"title":["Unique Monoclonal Antibodies Define Expression of Fc\u03b3RI on Macrophages and Mast Cell Lines and Demonstrate Heterogeneity Among Subcutaneous and Other Dendritic Cells"],"prefix":"10.1093","volume":"170","author":[{"given":"Peck S","family":"Tan","sequence":"first","affiliation":[{"name":"Austin Research Institute, Austin and Repatriation Medical Center , Heidelberg, Victoria ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda L","family":"Gavin","sequence":"additional","affiliation":[{"name":"The Scripps Research Institute , La Jolla, CA 92037"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadine","family":"Barnes","sequence":"additional","affiliation":[{"name":"Austin Research Institute, Austin and Repatriation Medical Center , Heidelberg, Victoria ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Duane W","family":"Sears","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, University of California , Santa Barbara, CA 93106"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Vremec","sequence":"additional","affiliation":[{"name":"Walter and Eliza Hall Institute of Medical Research , Parkville, Victoria ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ken","family":"Shortman","sequence":"additional","affiliation":[{"name":"Walter and Eliza Hall Institute of Medical Research , Parkville, Victoria ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian","family":"Amigorena","sequence":"additional","affiliation":[{"name":"Institut Curie, Section de Recherche , Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia L","family":"Mottram","sequence":"additional","affiliation":[{"name":"Austin Research Institute, Austin and Repatriation Medical Center , Heidelberg, Victoria ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P Mark","family":"Hogarth","sequence":"additional","affiliation":[{"name":"Austin Research Institute, Austin and Repatriation Medical Center , Heidelberg, Victoria ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2003,3,1]]},"reference":[{"key":"2026020210102881800_R1","first-page":"20","volume-title":"J. 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