{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T03:21:52Z","timestamp":1770088912884,"version":"3.49.0"},"reference-count":51,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2003,3,1]],"date-time":"2003-03-01T00:00:00Z","timestamp":1046476800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2003,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\u03b3\u03b4 T cells accumulate at epithelial barriers and at sites of inflammation in various infectious and autoimmune diseases, yet little is understood about the function of tissue-infiltrating \u03b3\u03b4 T cells. We observe that \u03b3\u03b4 T cells of the V\u03b41 subset accumulate in synovial fluid of human Lyme arthritis and are intensely cytolytic toward a wide array of target cells. Particularly striking is that the cytolytic activity is highly prolonged, lasting for at least 3 wk after stimulation of the \u03b3\u03b4 T cells with Borrelia burgdorferi. Cytolysis is largely Fas dependent and results from very high and prolonged expression of surface Fas ligand, which is transcriptionally regulated. This also manifests in a substantial level of self-induced apoptosis of the \u03b3\u03b4 T cells. In this capacity, certain \u03b3\u03b4 T cell subsets may serve as cytolytic sentinels at sites of inflammation, and perhaps at epithelial barriers.<\/jats:p>","DOI":"10.4049\/jimmunol.170.5.2702","type":"journal-article","created":{"date-parts":[[2014,4,20]],"date-time":"2014-04-20T21:32:44Z","timestamp":1398029564000},"page":"2702-2710","source":"Crossref","is-referenced-by-count":31,"title":["High Expression of Fas Ligand by Synovial Fluid-Derived \u03b3\u03b4 T Cells in Lyme Arthritis"],"prefix":"10.1093","volume":"170","author":[{"given":"Karen","family":"Roessner","sequence":"first","affiliation":[{"name":"Department of Medicine (Immunobiology), The University of Vermont College of Medicine , Burlington, VT 05405"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julie","family":"Wolfe","sequence":"additional","affiliation":[{"name":"Department of Medicine (Immunobiology), The University of Vermont College of Medicine , Burlington, VT 05405"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cuixia","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Medicine (Immunobiology), The University of Vermont College of Medicine , Burlington, VT 05405"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leonard H","family":"Sigal","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School , New Brunswick, NJ 08903"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sally","family":"Huber","sequence":"additional","affiliation":[{"name":"Department of Pathology, The University of Vermont College of Medicine , Burlington, VT 05405"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ralph C","family":"Budd","sequence":"additional","affiliation":[{"name":"Department of Medicine (Immunobiology), The University of Vermont College of Medicine , Burlington, VT 05405"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2003,3,1]]},"reference":[{"key":"2026020210071050600_R1","first-page":"1277","volume-title":"J. 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