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The mechanisms underlying these diverse outcomes are poorly understood. In particular, the role played by cells of the innate immune system, such as dendritic cells (DC), is not known. In this study, we show that Ebola and Lassa viruses infect human monocyte-derived DC and impair their function. Monocyte-derived DC exposed to either virus fail to secrete proinflammatory cytokines, do not up-regulate costimulatory molecules, and are poor stimulators of T cells. These data represent the first evidence for a mechanism by which Ebola and Lassa viruses target DC to impair adaptive immunity.<\/jats:p>","DOI":"10.4049\/jimmunol.170.6.2797","type":"journal-article","created":{"date-parts":[[2014,4,20]],"date-time":"2014-04-20T23:21:23Z","timestamp":1398036083000},"page":"2797-2801","source":"Crossref","is-referenced-by-count":300,"title":["Cutting Edge: Impairment of Dendritic Cells and Adaptive Immunity by Ebola and Lassa Viruses"],"prefix":"10.1093","volume":"170","author":[{"given":"Siddhartha","family":"Mahanty","sequence":"first","affiliation":[{"name":"Special Pathogens Branch, Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention , Atlanta, GA 30333"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen","family":"Hutchinson","sequence":"additional","affiliation":[{"name":"Special Pathogens Branch, Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention , Atlanta, GA 30333"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sudhanshu","family":"Agarwal","sequence":"additional","affiliation":[{"name":"Emory Vaccine Research Center and Department of Pathology, Emory University , Atlanta, GA 30329"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Mcrae","sequence":"additional","affiliation":[{"name":"Emory Vaccine Research Center and Department of Pathology, Emory University , Atlanta, GA 30329"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre E","family":"Rollin","sequence":"additional","affiliation":[{"name":"Special Pathogens Branch, Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention , Atlanta, GA 30333"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bali","family":"Pulendran","sequence":"additional","affiliation":[{"name":"Emory Vaccine Research Center and Department of Pathology, Emory University , Atlanta, GA 30329"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2003,3,15]]},"reference":[{"key":"2026020210122089000_R1","first-page":"12411","volume-title":"Proc. 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