{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T06:40:52Z","timestamp":1791268852918,"version":"4.1.0"},"reference-count":52,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2003,3,1]],"date-time":"2003-03-01T00:00:00Z","timestamp":1046476800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2003,3,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>In immune complex (IC) diseases, FcR are essential molecules facilitating polymorphonuclear cell (PMN) recruitment and effector functions at the IC site. Although FcR-dependent initial tethering and FcR\/integrin-dependent PMN accumulation were postulated, their underlying mechanisms remain unclear. We here addressed potential mechanisms involved in PMN recruitment in acute IC glomerulonephritis (nephrotoxic nephritis). Since some renal cells may be recruited from bone marrow (BM) lineages, reconstitution studies with BM chimeras and PMN transfer between wild-type (WT) and FcR-deficient mice (\u03b3\u2212\/\u2212) were performed. Severe glomerular damage was induced in WT and W\u03b3 chimeras (BM from WT to irradiated \u03b3\u2212\/\u2212), while it was absent in \u03b3\u2212\/\u2212 and \u03b3W chimeras (\u03b3\u2212\/\u2212 BM to WT). Moreover, WT PMN transfer, but not \u03b3\u2212\/\u2212 PMN, reconstituted the disease in \u03b3\u2212\/\u2212, indicating that FcR on resident cells is not a prerequisite for PMN recruitment in this disease. Surprisingly, transferred WT PMN were recruited coincidentally with NF-\u03baB activation and TNF-\u03b1 overexpression even in glomeruli with preformed IC (nephrotoxic Ab administered 3 days previously), suggesting that PMN can initially be recruited via its own FcR without previous chemoattractant release. Furthermore, H2O2 inhibition by catalase attenuated the acute WT PMN recruitment and the induction of NF-\u03baB and TNF-\u03b1 much more than integrin (CD18) blockade, indicating a role for the respiratory burst before integrin-dependent accumulation. In coculture experiments with IC-stimulated PMN and glomeruli, PMN caused acute glomerular TNF-\u03b1 expression predominantly via FcR-mediated H2O2 production. In conclusion, glomerular IC, even preformed, can cause PMN recruitment and injury through PMN FcR-mediated respiratory burst during initial PMN tethering to IC.<\/jats:p>","DOI":"10.4049\/jimmunol.170.6.3243","type":"journal-article","created":{"date-parts":[[2014,4,20]],"date-time":"2014-04-20T23:21:23Z","timestamp":1398036083000},"page":"3243-3253","source":"Crossref","is-referenced-by-count":33,"title":["Pre-Existing Glomerular Immune Complexes Induce Polymorphonuclear Cell Recruitment Through an Fc Receptor-Dependent Respiratory Burst: Potential Role in the Perpetuation of Immune Nephritis"],"prefix":"10.1093","volume":"170","author":[{"given":"Yusuke","family":"Suzuki","sequence":"first","affiliation":[{"name":"Renal and Vascular Research Laboratory, Fundacio\u0301n Jime\u0301nez Di\u0301az, Auto\u0301noma University , Madrid ,","place":["Spain"]},{"name":"Division of Nephrology, Department of Internal Medicine, Juntendo University School of Medicine , Tokyo ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"Go\u0301mez-Guerrero","sequence":"additional","affiliation":[{"name":"Renal and Vascular Research Laboratory, Fundacio\u0301n Jime\u0301nez Di\u0301az, Auto\u0301noma University , Madrid ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isao","family":"Shirato","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Internal Medicine, Juntendo University School of Medicine , Tokyo ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oscar","family":"Lo\u0301pez-Franco","sequence":"additional","affiliation":[{"name":"Renal and Vascular Research Laboratory, Fundacio\u0301n Jime\u0301nez Di\u0301az, Auto\u0301noma University , Madrid ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julio","family":"Gallego-Delgado","sequence":"additional","affiliation":[{"name":"Renal and Vascular Research Laboratory, Fundacio\u0301n Jime\u0301nez Di\u0301az, Auto\u0301noma University , Madrid ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillermo","family":"Sanjua\u0301n","sequence":"additional","affiliation":[{"name":"Renal and Vascular Research Laboratory, Fundacio\u0301n Jime\u0301nez Di\u0301az, Auto\u0301noma University , Madrid ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"La\u0301zaro","sequence":"additional","affiliation":[{"name":"Renal and Vascular Research Laboratory, Fundacio\u0301n Jime\u0301nez Di\u0301az, Auto\u0301noma University , Madrid ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Purificacio\u0301n","family":"Herna\u0301ndez-Vargas","sequence":"additional","affiliation":[{"name":"Renal and Vascular Research Laboratory, Fundacio\u0301n Jime\u0301nez Di\u0301az, Auto\u0301noma University , Madrid ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ko","family":"Okumura","sequence":"additional","affiliation":[{"name":"Department of Immunology, Juntendo University School of Medicine , Tokyo ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuhiko","family":"Tomino","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Internal Medicine, Juntendo University School of Medicine , Tokyo ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chisei","family":"Ra","sequence":"additional","affiliation":[{"name":"Department of Immunology, Juntendo University School of Medicine , Tokyo ,","place":["Japan"]},{"name":"Atopy (Allergy) Research Center, Juntendo University School of Medicine , Tokyo ,","place":["Japan"]},{"name":"Department of Molecular Cell Immunology and Allergology, Advanced Medical Research Center, Nihon University School of Medicine , Tokyo ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jesu\u0301s","family":"Egido","sequence":"additional","affiliation":[{"name":"Renal and Vascular Research Laboratory, Fundacio\u0301n Jime\u0301nez Di\u0301az, Auto\u0301noma University , Madrid ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2003,3,15]]},"reference":[{"key":"2026020210110054300_R1","first-page":"1059","volume-title":"J. 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