{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T12:54:32Z","timestamp":1783688072534,"version":"3.55.0"},"reference-count":47,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2003,3,1]],"date-time":"2003-03-01T00:00:00Z","timestamp":1046476800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2003,3,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Asthma and mouse models of allergic respiratory inflammation are invariably associated with a pulmonary eosinophilia; however, this association has remained correlative. In this report, a causative relationship between eosinophils and allergen-provoked pathologies was established using eosinophil adoptive transfer. Eosinophils were transferred directly into the lungs of either naive or OVA-treated IL-5\u2212\/\u2212 mice. This strategy resulted in a pulmonary eosinophilia equivalent to that observed in OVA-treated wild-type animals. A concomitant consequence of this eosinophil transfer was an increase in Th2 bronchoalveolar lavage cytokine levels and the restoration of intracellular epithelial mucus in OVA-treated IL-5\u2212\/\u2212 mice equivalent to OVA-treated wild-type levels. Moreover, the transfer also resulted in the development of airway hyperresponsiveness. These pulmonary changes did not occur when eosinophils were transferred into naive IL-5\u2212\/\u2212 mice, eliminating nonspecific consequences of the eosinophil transfer as a possible explanation. Significantly, administration of OVA-treated IL-5\u2212\/\u2212 mice with GK1.5 (anti-CD4) Abs abolished the increases in mucus accumulation and airway hyperresponsiveness following adoptive transfer of eosinophils. Thus, CD4+ T cell-mediated inflammatory signals as well as signals derived from eosinophils are each necessary, yet alone insufficient, for the development of allergic pulmonary pathology. These data support an expanded view of T cell and eosinophil activities and suggest that eosinophil effector functions impinge directly on lung function.<\/jats:p>","DOI":"10.4049\/jimmunol.170.6.3296","type":"journal-article","created":{"date-parts":[[2014,4,20]],"date-time":"2014-04-20T23:21:23Z","timestamp":1398036083000},"page":"3296-3305","source":"Crossref","is-referenced-by-count":130,"title":["A Causative Relationship Exists Between Eosinophils and the Development of Allergic Pulmonary Pathologies in the Mouse"],"prefix":"10.1093","volume":"170","author":[{"given":"HuaHao H","family":"Shen","sequence":"first","affiliation":[{"name":"Division of Hematology\/Oncology, Department of Biochemistry and Molecular Biology, Mayo Clinic Scottsdale, S. C. Johnson Medical Research Center , Scottsdale, AZ 85259"},{"name":"Department of Respiratory Medicine, Second Hospital, Zhejiang University College of Medicine , Hangzhou ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergei I","family":"Ochkur","sequence":"additional","affiliation":[{"name":"Division of Pulmonary Medicine, Department of Biochemistry and Molecular Biology, Mayo Clinic Scottsdale, S. C. Johnson Medical Research Center , Scottsdale, AZ 85259"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael P","family":"McGarry","sequence":"additional","affiliation":[{"name":"Division of Pulmonary Medicine, Department of Biochemistry and Molecular Biology, Mayo Clinic Scottsdale, S. C. Johnson Medical Research Center , Scottsdale, AZ 85259"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey R","family":"Crosby","sequence":"additional","affiliation":[{"name":"Division of Hematology\/Oncology, Department of Biochemistry and Molecular Biology, Mayo Clinic Scottsdale, S. C. Johnson Medical Research Center , Scottsdale, AZ 85259"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edie M","family":"Hines","sequence":"additional","affiliation":[{"name":"Division of Hematology\/Oncology, Department of Biochemistry and Molecular Biology, Mayo Clinic Scottsdale, S. C. Johnson Medical Research Center , Scottsdale, AZ 85259"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael T","family":"Borchers","sequence":"additional","affiliation":[{"name":"Division of Pulmonary Medicine, Department of Biochemistry and Molecular Biology, Mayo Clinic Scottsdale, S. C. Johnson Medical Research Center , Scottsdale, AZ 85259"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiying","family":"Wang","sequence":"additional","affiliation":[{"name":"Division of Hematology\/Oncology, Department of Biochemistry and Molecular Biology, Mayo Clinic Scottsdale, S. C. Johnson Medical Research Center , Scottsdale, AZ 85259"},{"name":"Department of Respiratory Medicine, Second Hospital, Zhejiang University College of Medicine , Hangzhou ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Travis L","family":"Biechelle","sequence":"additional","affiliation":[{"name":"Division of Hematology\/Oncology, Department of Biochemistry and Molecular Biology, Mayo Clinic Scottsdale, S. C. Johnson Medical Research Center , Scottsdale, AZ 85259"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katie R","family":"O\u2019Neill","sequence":"additional","affiliation":[{"name":"Division of Hematology\/Oncology, Department of Biochemistry and Molecular Biology, Mayo Clinic Scottsdale, S. C. Johnson Medical Research Center , Scottsdale, AZ 85259"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tracy L","family":"Ansay","sequence":"additional","affiliation":[{"name":"Division of Hematology\/Oncology, Department of Biochemistry and Molecular Biology, Mayo Clinic Scottsdale, S. C. Johnson Medical Research Center , Scottsdale, AZ 85259"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dana C","family":"Colbert","sequence":"additional","affiliation":[{"name":"Division of Pulmonary Medicine, Department of Biochemistry and Molecular Biology, Mayo Clinic Scottsdale, S. C. 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