{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T02:27:28Z","timestamp":1770085648430,"version":"3.49.0"},"reference-count":60,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2003,3,1]],"date-time":"2003-03-01T00:00:00Z","timestamp":1046476800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2003,3,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>UVB exposure can alter immune responses in experimental animals and humans. In an earlier human volunteer study, we demonstrated that hepatitis B-specific humoral and cellular immunity after vaccination on average were not significantly affected by UVB exposure. However, it is known that individuals differ in their susceptibility to UVB-induced immunomodulation, and it was hypothesized that polymorphisms in specific cytokines may play a role in this susceptibility. In this respect, we previously demonstrated that immune responses after hepatitis B vaccination are influenced by the minor allelic variant of IL-1\u03b2 in the general population. For all volunteers, single nucleotide polymorphisms were determined for the following UV response-related cytokines: IL-1 receptor antagonist (+2018), IL-1\u03b1 (+4845), IL-1\u03b2 (+3953), TNF-\u03b1 (\u2212308), and TNF-\u03b1 (\u2212238). Exposure to UVB significantly suppressed Ab responses to hepatitis B in individuals with the minor variant for the IL-1\u03b2 polymorphism. Increased minimal erythema dose values (just perceptible), which resulted in higher absolute UVB exposures, were observed in the same individuals. There were no associations observed between UVB-induced immunomodulation and the other cytokine polymorphisms examined. This study indicates that individual susceptibility to UVB radiation needs to be considered when studying the effects of UVB in humans.<\/jats:p>","DOI":"10.4049\/jimmunol.170.6.3423","type":"journal-article","created":{"date-parts":[[2014,4,20]],"date-time":"2014-04-20T23:21:23Z","timestamp":1398036083000},"page":"3423-3428","source":"Crossref","is-referenced-by-count":54,"title":["Cytokine Polymorphisms Play a Role in Susceptibility to Ultraviolet B-Induced Modulation of Immune Responses after Hepatitis B Vaccination"],"prefix":"10.1093","volume":"170","author":[{"given":"Annemarie","family":"Sleijffers","sequence":"first","affiliation":[{"name":"National Institute of Public Health and the Environment , Bilthoven ,","place":["The Netherlands"]},{"name":"Department of Dermatology, University Medical Center , Utrecht ,","place":["The Netherlands"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Berran","family":"Yucesoy","sequence":"additional","affiliation":[{"name":"National Institute for Occupational Safety and Health , Morgantown, WV 26505"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Kashon","sequence":"additional","affiliation":[{"name":"National Institute for Occupational Safety and Health , Morgantown, WV 26505"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johan","family":"Garssen","sequence":"additional","affiliation":[{"name":"National Institute of Public Health and the Environment , Bilthoven ,","place":["The Netherlands"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frank R","family":"De Gruijl","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Leiden University Medical Center , Leiden ,","place":["The Netherlands"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Greet J","family":"Boland","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, University Medical Center , Utrecht ,","place":["The Netherlands"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan","family":"Van Hattum","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, University Medical Center , Utrecht ,","place":["The Netherlands"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael I","family":"Luster","sequence":"additional","affiliation":[{"name":"National Institute for Occupational Safety and Health , Morgantown, WV 26505"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henk","family":"Van Loveren","sequence":"additional","affiliation":[{"name":"National Institute of Public Health and the Environment , Bilthoven ,","place":["The Netherlands"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2003,3,15]]},"reference":[{"key":"2026020210101197500_R1","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1007\/978-1-4899-1313-5_10","volume-title":"Photobiology in Medicine","year":"1994"},{"key":"2026020210101197500_R2","first-page":"20","volume-title":"J. 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