{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T19:22:46Z","timestamp":1791400966084,"version":"4.3.3"},"reference-count":24,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2003,4,1]],"date-time":"2003-04-01T00:00:00Z","timestamp":1049155200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2003,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Human \u03b3\u03b4 T cells bearing V\u03b32V\u03b42-TCR recognize various kinds of small nonpeptide Ags, and activation of them by a nitrogen-containing bisphosphonate Ag, pamidronate, requires Ag presentation by cells other than \u03b3\u03b4 T cells, including many human tumor cells. Present results demonstrated that tumor cell lines of nonhuman origins pulsed with pamidronate failed to activate human \u03b3\u03b4 T cells without exception, whereas most if not all human tumor cell lines could do so. \u03b3\u03b4 T cells formed stable conjugates with pamidronate-pulsed human tumor cells and both conjugate formation and \u03b3\u03b4 T cell activation were inhibited significantly by anti-LFA-1 mAb, suggesting the requirement of LFA-1-mediated interaction with APC for efficient \u03b3\u03b4 T cell activation. Consistently, ICAM-1low tumor cell lines pulsed with pamidronate induced no or only weak activation of \u03b3\u03b4 T cells, whereas similarly treated ICAM-1high cell lines could activate them. One of the two ICAM-1low tumor cell lines pulsed with pamidronate induced strong \u03b3\u03b4 T cell activation after ICAM-1 gene transfer. However, another ICAM-1low human cell line as well as murine tumor cell lines pulsed with pamidronate remained totally defective in \u03b3\u03b4 T cell activation even after expression of human ICAM-1. These results suggested that activation of human \u03b3\u03b4 T cells by nonpeptide Ags required species-specific interactions in addition to LFA-1\/ICAM-1-mediated cell adhesion with APC.<\/jats:p>","DOI":"10.4049\/jimmunol.170.7.3608","type":"journal-article","created":{"date-parts":[[2014,4,20]],"date-time":"2014-04-20T19:28:40Z","timestamp":1398022120000},"page":"3608-3613","source":"Crossref","is-referenced-by-count":75,"title":["Requirement of Species-Specific Interactions for the Activation of Human \u03b3\u03b4 T Cells by Pamidronate"],"prefix":"10.1093","volume":"170","author":[{"given":"Yu","family":"Kato","sequence":"first","affiliation":[{"name":"Department of Immunology and Cell Biology, Graduate Schools of Biostudies and Medicine, Kyoto University , Kyoto ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshimasa","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Department of Immunology and Cell Biology, Graduate Schools of Biostudies and Medicine, Kyoto University , Kyoto ,","place":["Japan"]},{"name":"PRESTO, JST , Kyoto ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hidenori","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Graduate Schools of Biostudies and Medicine, Kyoto University , Kyoto ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seiji","family":"Yamashita","sequence":"additional","affiliation":[{"name":"Department of Immunology and Cell Biology, Graduate Schools of Biostudies and Medicine, Kyoto University , Kyoto ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nagahiro","family":"Minato","sequence":"additional","affiliation":[{"name":"Department of Immunology and Cell Biology, Graduate Schools of Biostudies and Medicine, Kyoto University , Kyoto ,","place":["Japan"]},{"name":"Graduate Schools of Biostudies and Medicine, Kyoto University , Kyoto ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2003,4,1]]},"reference":[{"key":"2026020210045551800_R1","first-page":"975","volume-title":"Annu. Rev. Immunol.","year":"2000"},{"key":"2026020210045551800_R2","first-page":"8175","volume-title":"Proc. Natl. Acad. Sci. USA","year":"1994"},{"key":"2026020210045551800_R3","first-page":"267","volume-title":"Science","year":"1994"},{"key":"2026020210045551800_R4","first-page":"155","volume-title":"Nature","year":"1995"},{"key":"2026020210045551800_R5","first-page":"32079","volume-title":"J. Biol. Chem.","year":"1999"},{"key":"2026020210045551800_R6","first-page":"57","volume-title":"Immunity","year":"1999"},{"key":"2026020210045551800_R7","first-page":"737","volume-title":"N. Engl. J. Med.","year":"1999"},{"key":"2026020210045551800_R8","first-page":"384","volume-title":"Blood","year":"2000"},{"key":"2026020210045551800_R9","first-page":"5508","volume-title":"J. Immunol.","year":"2001"},{"key":"2026020210045551800_R10","first-page":"1669","volume-title":"FASEB J.","year":"2000"},{"key":"2026020210045551800_R11","first-page":"6773","volume-title":"J. Immunol.","year":"2001"},{"key":"2026020210045551800_R12","first-page":"820","volume-title":"Nature","year":"2001"},{"key":"2026020210045551800_R13","first-page":"5092","volume-title":"J. Immunol.","year":"2001"},{"key":"2026020210045551800_R14","first-page":"495","volume-title":"Immunity","year":"1995"},{"key":"2026020210045551800_R15","first-page":"6336","volume-title":"J. Immunol.","year":"2002"},{"key":"2026020210045551800_R16","first-page":"5249","volume-title":"J. Immunol.","year":"1995"},{"key":"2026020210045551800_R17","first-page":"82","volume-title":"Nature","year":"1998"},{"key":"2026020210045551800_R18","first-page":"221","volume-title":"Science","year":"1999"},{"key":"2026020210045551800_R19","first-page":"375","volume-title":"Annu. Rev. Immunol.","year":"2001"},{"key":"2026020210045551800_R20","first-page":"1001","volume-title":"Mol. Cell. Biol.","year":"2002"},{"key":"2026020210045551800_R21","first-page":"29","volume-title":"Annu. Rev. Immunol.","year":"2002"},{"key":"2026020210045551800_R22","first-page":"649","volume-title":"Science","year":"1999"},{"key":"2026020210045551800_R23","first-page":"1437","volume-title":"Int. Immunol.","year":"1993"},{"key":"2026020210045551800_R24","first-page":"5986","volume-title":"J. Immunol.","year":"1995"}],"container-title":["The Journal of Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/170\/7\/3608\/62564134\/3608.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/170\/7\/3608\/62564134\/3608.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T15:06:18Z","timestamp":1770044778000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jimmunol\/article\/170\/7\/3608\/8028099"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,4,1]]},"references-count":24,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2003,4,1]]},"published-print":{"date-parts":[[2003,4,1]]}},"URL":"https:\/\/doi.org\/10.4049\/jimmunol.170.7.3608","relation":{},"ISSN":["0022-1767","1550-6606"],"issn-type":[{"value":"0022-1767","type":"print"},{"value":"1550-6606","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2003,4]]},"published":{"date-parts":[[2003,4,1]]}}}