{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T10:22:04Z","timestamp":1770891724643,"version":"3.50.1"},"reference-count":35,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2003,4,1]],"date-time":"2003-04-01T00:00:00Z","timestamp":1049155200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2003,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>An autoantibody against SS-A\/Ro52 (Ro52) is most frequently found in the sera of patients with Sjo\u0308gren\u2019s syndrome, systemic lupus erythematosus, and congenital heart block from anti-Ro52 Ab-positive mother. However, the physiological function of the autoantigen SS-A\/Ro52 has not yet been elucidated. In this study, we describe the role of Ro52 protein in T cell activation. Overexpression of SS-A\/Ro52 in Jurkat T cell resulted in enhanced IL-2 production following CD28 stimulation. Furthermore, transfection of anti-Ro52-specific small RNA duplexes partially blocked the expression of native and overexpressed Ro52 in Jurkat T cell, resulting in decreased IL-2 production via CD28 pathway in these cells. Finally, intracellular localization of Ro52 dramatically changed following CD28 stimulation. Our data reveal a novel function of Ro52 in CD28-mediated pathway, which eventually contributes to cytokine production and expression of the T cell biological programs.<\/jats:p>","DOI":"10.4049\/jimmunol.170.7.3653","type":"journal-article","created":{"date-parts":[[2014,4,20]],"date-time":"2014-04-20T19:28:40Z","timestamp":1398022120000},"page":"3653-3661","source":"Crossref","is-referenced-by-count":44,"title":["SS-A\/Ro52, an Autoantigen Involved in CD28-Mediated IL-2 Production"],"prefix":"10.1093","volume":"170","author":[{"given":"Tomonori","family":"Ishii","sequence":"first","affiliation":[{"name":"Department of Cancer Immunology and AIDS, Dana-Farber Cancer Institute, Harvard Medical School , Boston, MA 02115"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kei","family":"Ohnuma","sequence":"additional","affiliation":[{"name":"Division of Clinical Immunology, Advanced Clinical Research Center, Institute of Medical Science, University of Tokyo , Tokyo ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akikazu","family":"Murakami","sequence":"additional","affiliation":[{"name":"Department of Cancer Immunology and AIDS, Dana-Farber Cancer Institute, Harvard Medical School , Boston, MA 02115"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naruhiko","family":"Takasawa","sequence":"additional","affiliation":[{"name":"Department of Cancer Immunology and AIDS, Dana-Farber Cancer Institute, Harvard Medical School , Boston, MA 02115"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tadanori","family":"Yamochi","sequence":"additional","affiliation":[{"name":"Department of Lymphoma\/Myeloma, MD Anderson Cancer Center , Houston, TX 77030"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoshi","family":"Iwata","sequence":"additional","affiliation":[{"name":"Division of Clinical Immunology, Advanced Clinical Research Center, Institute of Medical Science, University of Tokyo , Tokyo ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masahiko","family":"Uchiyama","sequence":"additional","affiliation":[{"name":"Division of Clinical Immunology, Advanced Clinical Research Center, Institute of Medical Science, University of Tokyo , Tokyo ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nam H","family":"Dang","sequence":"additional","affiliation":[{"name":"Department of Lymphoma\/Myeloma, MD Anderson Cancer Center , Houston, TX 77030"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hirotoshi","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Division of Clinical Immunology, Advanced Clinical Research Center, Institute of Medical Science, University of Tokyo , Tokyo ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chikao","family":"Morimoto","sequence":"additional","affiliation":[{"name":"Division of Clinical Immunology, Advanced Clinical Research Center, Institute of Medical Science, University of Tokyo , Tokyo ,","place":["Japan"]},{"name":"Department of Lymphoma\/Myeloma, MD Anderson Cancer Center , Houston, TX 77030"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2003,4,1]]},"reference":[{"key":"2026020210051305600_R1","first-page":"1560","volume-title":"J. 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