{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T03:52:38Z","timestamp":1770090758288,"version":"3.49.0"},"reference-count":51,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2003,4,1]],"date-time":"2003-04-01T00:00:00Z","timestamp":1049155200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2003,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The B cell C receptor specific for C3dg (CR2) shares a number of features with the primate E C receptor (CR1). Previously, we have demonstrated, both in vitro and in animal models, that immune complexes (IC) bound to primate E CR1, either via C opsonization or by means of bispecific mAb complexes, can be transferred to acceptor macrophages in a process that also removes CR1 from the E. We have now extended this paradigm, the transfer reaction, to include B cell CR2. We used both flow cytometry and fluorescence microscopy to demonstrate that IC bound to Raji cell CR2, either via C opsonization or through the use of an anti-CR2 mAb, are transferred to acceptor THP-1 cells. This reaction, which appears to require Fc recognition of IgG bound to Raji cell CR2, also leads to transfer of CR2. Additional support for the B cell transfer reaction is provided in a prototype study in a monkey model in which IC bound to B cell CR2 are localized to the spleen. These findings may have important implications with respect to defining the role of C in IC handling during the normal immune response.<\/jats:p>","DOI":"10.4049\/jimmunol.170.7.3671","type":"journal-article","created":{"date-parts":[[2014,4,20]],"date-time":"2014-04-20T19:28:40Z","timestamp":1398022120000},"page":"3671-3678","source":"Crossref","is-referenced-by-count":25,"title":["B Cell Complement Receptor 2 Transfer Reaction"],"prefix":"10.1093","volume":"170","author":[{"given":"Margaret A","family":"Lindorfer","sequence":"first","affiliation":[{"name":"Department of Biochemistry and Molecular Genetics and Center for Comparative Medicine, University of Virginia Health Sciences Center , Charlottesville, VA 22908"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hasmig B","family":"Jinivizian","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Genetics and Center for Comparative Medicine, University of Virginia Health Sciences Center , Charlottesville, VA 22908"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patricia L","family":"Foley","sequence":"additional","affiliation":[{"name":"Center for Comparative Medicine, University of Virginia Health Sciences Center , Charlottesville, VA 22908"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adam D","family":"Kennedy","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Genetics and Center for Comparative Medicine, University of Virginia Health Sciences Center , Charlottesville, VA 22908"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael D","family":"Solga","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Genetics and Center for Comparative Medicine, University of Virginia Health Sciences Center , Charlottesville, VA 22908"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ronald P","family":"Taylor","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Genetics and Center for Comparative Medicine, University of Virginia Health Sciences Center , Charlottesville, VA 22908"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2003,4,1]]},"reference":[{"key":"2026020210080246500_R1","first-page":"157","volume-title":"Nat. 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