{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T11:04:04Z","timestamp":1790939044639,"version":"4.1.0"},"reference-count":44,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2003,4,1]],"date-time":"2003-04-01T00:00:00Z","timestamp":1049155200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2003,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Gastric infection with Helicobacter induces a lymphocyte-rich mucosal inflammation that contains a minor population of neutrophilic granulocytes. The function of neutrophils in the local immune response to gastric Helicobacter infection remains unknown. To investigate this issue, we conducted experiments in neutrophil-depleted control wild-type (wt) and IL-10\u2212\/\u2212 mice infected with Helicobacter felis by gastric lavage. Infection of wt mice elicited a mild, focal gastritis and a Helicobacter-specific Th1 immune response. In wt mice Helicobacter colonization of the stomach was persistent and progressively increased during the 29 days of observation. Infection of IL-10\u2212\/\u2212 mice with H. felis elicited a severe chronic gastritis and a greatly enhanced Helicobacter-specific Th1 immune response, as compared with wt mice. After initial colonization, the IL-0\u2212\/\u2212 mice completely cleared Helicobacter from the stomach by day 8. The gastric inflammation in wt and IL-10\u2212\/\u2212 mice contained modest numbers of neutrophils. The intensity of gastric inflammation and the extent of Helicobacter colonization were similar in control and in neutrophil-depleted wt mice. In contrast, neutrophil depletion of Helicobacter-infected IL-10\u2212\/\u2212 mice decreased the severity of gastritis, modulated the Helicobacter-specific Th1 immune response, and delayed the clearance of bacteria from the stomach. These studies identify a role for neutrophils in the local and systemic immune response to gastric Helicobacter in IL-10\u2212\/\u2212 mice.<\/jats:p>","DOI":"10.4049\/jimmunol.170.7.3782","type":"journal-article","created":{"date-parts":[[2014,4,20]],"date-time":"2014-04-20T19:28:40Z","timestamp":1398022120000},"page":"3782-3789","source":"Crossref","is-referenced-by-count":97,"title":["Depletion of Neutrophils in IL-10\u2212\/\u2212 Mice Delays Clearance of Gastric\n                    <i>Helicobacter<\/i>\n                    Infection and Decreases the Th1 Immune Response to\n                    <i>Helicobacter<\/i>"],"prefix":"10.1093","volume":"170","author":[{"given":"Hanan F","family":"Ismail","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, University of Iowa College of Medicine , Iowa City, Iowa 52242"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pamela","family":"Fick","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University of Iowa College of Medicine , Iowa City, Iowa 52242"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University of Iowa College of Medicine , Iowa City, Iowa 52242"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard G","family":"Lynch","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Iowa College of Medicine , Iowa City, Iowa 52242"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel J","family":"Berg","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University of Iowa College of Medicine , Iowa City, Iowa 52242"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2003,4,1]]},"reference":[{"key":"2026020210075639500_R1","first-page":"1311","volume-title":"Lancet","year":"1984"},{"key":"2026020210075639500_R2","first-page":"962","volume-title":"J. Immunol.","year":"1997"},{"key":"2026020210075639500_R3","first-page":"4729","volume-title":"J. Immunol.","year":"1996"},{"key":"2026020210075639500_R4","first-page":"720","volume-title":"Gastroenterology","year":"1992"},{"key":"2026020210075639500_R5","first-page":"65","volume-title":"Scand. J. Gastroenterol. Suppl.","year":"1991"},{"key":"2026020210075639500_R6","first-page":"787","volume-title":"J. Med. Microbiol.","year":"2001"},{"key":"2026020210075639500_R7","first-page":"73","volume-title":"Clin. Exp. Immunol.","year":"2001"},{"key":"2026020210075639500_R8","first-page":"1749","volume-title":"J. Infect. Dis.","year":"2000"},{"key":"2026020210075639500_R9","first-page":"21","volume-title":"Gastroenterology","year":"1996"},{"key":"2026020210075639500_R10","first-page":"2213","volume-title":"Infect. Immun.","year":"1995"},{"key":"2026020210075639500_R11","first-page":"1277","volume-title":"Dig. Dis. Sci.","year":"1991"},{"key":"2026020210075639500_R12","first-page":"1332","volume-title":"Dig. Dis. Sci.","year":"1995"},{"key":"2026020210075639500_R13","first-page":"31","volume-title":"Int. J. Syst. Bacteriol.","year":"1991"},{"key":"2026020210075639500_R14","first-page":"1848","volume-title":"Gastroenterology","year":"1997"},{"key":"2026020210075639500_R15","first-page":"279","volume-title":"Infect. Immun.","year":"1999"},{"key":"2026020210075639500_R16","first-page":"1153","volume-title":"Scand. J. Gastroenterol.","year":"1995"},{"key":"2026020210075639500_R17","first-page":"1377","volume-title":"Am. J. Pathol.","year":"1998"},{"key":"2026020210075639500_R18","first-page":"575","volume-title":"Ann. Med.","year":"1995"},{"key":"2026020210075639500_R19","first-page":"1010","volume-title":"J. Clin. Invest.","year":"1996"},{"key":"2026020210075639500_R20","first-page":"19.8.1","volume-title":"Current Protocols in Immunology","year":"2000"},{"key":"2026020210075639500_R21","first-page":"942","volume-title":"J. Clin. Microbiol.","year":"1996"},{"key":"2026020210075639500_R22","first-page":"345","volume-title":"Anal. Biochem.","year":"1983"},{"key":"2026020210075639500_R23","first-page":"1490","volume-title":"J. Immunol.","year":"1999"},{"key":"2026020210075639500_R24","first-page":"S198","volume-title":"J. Clin. Gastroenterol.","year":"1997"},{"key":"2026020210075639500_R25","first-page":"29","volume-title":"Aliment. Pharmacol. Ther.","year":"1996"},{"key":"2026020210075639500_R26","first-page":"744","volume-title":"Dig. Dis. Sci.","year":"1994"},{"key":"2026020210075639500_R27","first-page":"245","volume-title":"Schweiz. Med. Wochenschr.","year":"1991"},{"key":"2026020210075639500_R28","first-page":"196","volume-title":"Gut","year":"1997"},{"key":"2026020210075639500_R29","first-page":"2356","volume-title":"J. Immunol.","year":"1997"},{"key":"2026020210075639500_R30","first-page":"3355","volume-title":"J. Immunol.","year":"2001"},{"key":"2026020210075639500_R31","first-page":"4638","volume-title":"J. Immunol.","year":"1996"},{"key":"2026020210075639500_R32","first-page":"3728","volume-title":"J. Immunol.","year":"1993"},{"key":"2026020210075639500_R33","first-page":"3485","volume-title":"Eur. J. Immunol.","year":"1999"},{"key":"2026020210075639500_R34","first-page":"H1555","volume-title":"Am. J. Physiol.","year":"2000"},{"key":"2026020210075639500_R35","first-page":"440","volume-title":"Immunology","year":"1997"},{"key":"2026020210075639500_R36","first-page":"181","volume-title":"FEMS Immunol. Med. Microbiol.","year":"1996"},{"key":"2026020210075639500_R37","first-page":"151","volume-title":"Exp. Hematol.","year":"1996"},{"key":"2026020210075639500_R38","first-page":"279","volume-title":"Folia Microbiol.","year":"1998"},{"key":"2026020210075639500_R39","first-page":"2829","volume-title":"Infect. Immun.","year":"1996"},{"key":"2026020210075639500_R40","first-page":"7456","volume-title":"J. Immunol.","year":"2001"},{"key":"2026020210075639500_R41","first-page":"645","volume-title":"Immunology","year":"1994"},{"key":"2026020210075639500_R42","first-page":"3838","volume-title":"Blood","year":"2000"},{"key":"2026020210075639500_R43","first-page":"212","volume-title":"Blood","year":"2000"},{"key":"2026020210075639500_R44","first-page":"1171","volume-title":"J. Exp. Med.","year":"2001"}],"container-title":["The Journal of Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/170\/7\/3782\/62564687\/3782.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/170\/7\/3782\/62564687\/3782.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T15:10:00Z","timestamp":1770045000000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jimmunol\/article\/170\/7\/3782\/8028293"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,4,1]]},"references-count":44,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2003,4,1]]},"published-print":{"date-parts":[[2003,4,1]]}},"URL":"https:\/\/doi.org\/10.4049\/jimmunol.170.7.3782","relation":{},"ISSN":["0022-1767","1550-6606"],"issn-type":[{"value":"0022-1767","type":"print"},{"value":"1550-6606","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2003,4]]},"published":{"date-parts":[[2003,4,1]]}}}