{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T21:02:31Z","timestamp":1791147751000,"version":"4.1.0"},"reference-count":35,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2003,4,1]],"date-time":"2003-04-01T00:00:00Z","timestamp":1049155200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2003,4,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Viral infections may cause serious disease unless the adaptive immune system is able to clear the viral agents through its effector arms. Recent identification and functional characterization of subpopulations of human CD8+ T cells has set the stage to study the correlation between the appearance of particular subsets and common viral infections during childhood, i.e., EBV, CMV, varicella-zoster virus (VZV), and the attenuated measles-mumps-rubella (MMR) vaccine strains. In a cohort of 220 healthy children we analyzed lymphocytes and subpopulations of CD4+ and CD8+ T cells. The presence of the cytolytic CD45RA+CD27\u2212 subset of CD8+ T cells correlated with prior CMV infection as defined by seroconversion (p &amp;lt; 0.0001). The number of this CD8+ T cell subset remained stable during follow-up over 3 years in 40 children. The CD45RA+CD27\u2212 subset of CD8+ T cells first appeared during acute CMV infection and subsequently stabilized at an individual set-point defined by age and immunocompetence. The functional importance of these cells in CMV surveillance was reflected by their increased numbers in immunosuppressed pediatric kidney transplant patients. Preferential expansion of CD8+CD45RA+CD27\u2212 cytolytic T cells seems unique for CMV.<\/jats:p>","DOI":"10.4049\/jimmunol.170.8.4342","type":"journal-article","created":{"date-parts":[[2014,4,20]],"date-time":"2014-04-20T22:24:43Z","timestamp":1398032683000},"page":"4342-4348","source":"Crossref","is-referenced-by-count":138,"title":["Frequencies of Circulating Cytolytic, CD45RA+CD27\u2212, CD8+ T Lymphocytes Depend on Infection with CMV"],"prefix":"10.1093","volume":"170","author":[{"given":"Taco W","family":"Kuijpers","sequence":"first","affiliation":[{"name":"Emma Children\u2019s Hospital, Central Laboratory of the Netherlands Red Cross Blood Transfusion Service , Amsterdam ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mireille T","family":"Vossen","sequence":"additional","affiliation":[{"name":"Emma Children\u2019s Hospital, Central Laboratory of the Netherlands Red Cross Blood Transfusion Service , Amsterdam ,","place":["The Netherlands"]},{"name":"Laboratory for Experimental Immunology, Central Laboratory of the Netherlands Red Cross Blood Transfusion Service , Amsterdam ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mi-Ran","family":"Gent","sequence":"additional","affiliation":[{"name":"Emma Children\u2019s Hospital, Central Laboratory of the Netherlands Red Cross Blood Transfusion Service , Amsterdam ,","place":["The Netherlands"]},{"name":"Laboratory for Experimental Immunology, Central Laboratory of the Netherlands Red Cross Blood Transfusion Service , Amsterdam ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Claude","family":"Davin","sequence":"additional","affiliation":[{"name":"Emma Children\u2019s Hospital, Central Laboratory of the Netherlands Red Cross Blood Transfusion Service , Amsterdam ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marijke T","family":"Roos","sequence":"additional","affiliation":[{"name":"Department of Clinical Viro-Immunology, Central Laboratory of the Netherlands Red Cross Blood Transfusion Service , Amsterdam ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pauline M","family":"Wertheim-van Dillen","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology, Section of Clinical Virology, Academic Medical Center, Central Laboratory of the Netherlands Red Cross Blood Transfusion Service , Amsterdam ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan F","family":"Weel","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology, Section of Clinical Virology, Academic Medical Center, Central Laboratory of the Netherlands Red Cross Blood Transfusion Service , Amsterdam ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul A","family":"Baars","sequence":"additional","affiliation":[{"name":"Laboratory for Experimental Immunology, Central Laboratory of the Netherlands Red Cross Blood Transfusion Service , Amsterdam ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rene A","family":"van Lier","sequence":"additional","affiliation":[{"name":"Laboratory for Experimental Immunology, Central Laboratory of the Netherlands Red Cross Blood Transfusion Service , Amsterdam ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2003,4,15]]},"reference":[{"key":"2026020210050625300_R1","first-page":"248","volume-title":"Curr. 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