{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T04:45:09Z","timestamp":1788410709891,"version":"build-2803163510"},"reference-count":36,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2017,7,1]],"date-time":"2017-07-01T00:00:00Z","timestamp":1498867200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,7,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Long noncoding RNAs (lncRNAs) have emerged as critical regulators of inflammation. To further understand the interaction between inflammatory signaling pathways and lncRNAs, we characterized the function of cardiac and apoptosis-related lncRNA (Carlr), an lncRNA expressed in both mouse and human cells of diverse tissues. Carlr expression is increased following NF-\u03baB signaling in macrophages, with concomitant translocation to, and enrichment of, the transcript in the cytoplasm. Knockdown of Carlr results in impaired expression of NF-\u03baB pathway genes and influences the interaction between macrophages and intestinal cells in an inflammatory environment. In human celiac disease patient samples, increased levels of the Carlr transcript were detected in the cytoplasm, alongside elevated expression of NF-\u03baB pathway genes. These findings suggest that increased Carlr expression and\/or cytoplasmic localization is required for efficient NF-\u03baB signaling and is associated with the inflamed tissue state observed in human celiac disease.<\/jats:p>","DOI":"10.4049\/jimmunol.1700023","type":"journal-article","created":{"date-parts":[[2017,6,17]],"date-time":"2017-06-17T00:20:22Z","timestamp":1497658822000},"page":"581-588","source":"Crossref","is-referenced-by-count":45,"title":["Cytoplasmic Form of Carlr lncRNA Facilitates Inflammatory Gene Expression upon NF-\u03baB Activation"],"prefix":"10.1093","volume":"199","author":[{"given":"Ainara","family":"Castellanos-Rubio","sequence":"first","affiliation":[{"name":"Department of Microbiology and Immunology, College of Physicians and Surgeons, Columbia University , New York, NY 10032"},{"name":"Immunogenetics Research Laboratory, Department of Genetics, Physical Anthropology and Animal Physiology, University of the Basque Country , UPV\/EHU, 48940 Leioa,","place":["Spain"]},{"name":"BioCruces Health Research Institute , 48903 Barakaldo,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Radomir","family":"Kratchmarov","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, College of Physicians and Surgeons, Columbia University , New York, NY 10032"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maialen","family":"Sebastian","sequence":"additional","affiliation":[{"name":"Immunogenetics Research Laboratory, Department of Genetics, Physical Anthropology and Animal Physiology, University of the Basque Country , UPV\/EHU, 48940 Leioa,","place":["Spain"]},{"name":"BioCruces Health Research Institute , 48903 Barakaldo,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koldo","family":"Garcia-Etxebarria","sequence":"additional","affiliation":[{"name":"Immunogenetics Research Laboratory, Department of Genetics, Physical Anthropology and Animal Physiology, University of the Basque Country , UPV\/EHU, 48940 Leioa,","place":["Spain"]},{"name":"BioCruces Health Research Institute , 48903 Barakaldo,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liher","family":"Garcia","sequence":"additional","affiliation":[{"name":"Immunogenetics Research Laboratory, Department of Genetics, Physical Anthropology and Animal Physiology, University of the Basque Country , UPV\/EHU, 48940 Leioa,","place":["Spain"]},{"name":"BioCruces Health Research Institute , 48903 Barakaldo,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I\u00f1aki","family":"Irastorza","sequence":"additional","affiliation":[{"name":"Pediatric Gastroenterology Unit, Cruces University Hospital, University of the Basque Country , UPV\/EHU, 48903 Barakaldo 48903,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sankar","family":"Ghosh","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, College of Physicians and Surgeons, Columbia University , New York, NY 10032"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2017,7,15]]},"reference":[{"key":"2025030614182859400_r1","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1016\/j.immuni.2015.05.004","article-title":"Long noncoding RNA in hematopoiesis and immunity","volume":"42","author":"Satpathy","year":"2015","journal-title":"Immunity"},{"key":"2025030614182859400_r2","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1146\/annurev-biochem-051410-092902","article-title":"Genome regulation by long noncoding RNAs","volume":"81","author":"Rinn","year":"2012","journal-title":"Annu. 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