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In addition, we demonstrate that the susceptibility of Th1 cells to glycolysis restriction depends on the activation conditions and that under diminished glycolytic flux, mannose availability becomes the limiting factor for IFN-\u03b3 expression. This study unravels a new role for glucose metabolism in the differentiation process of Th1 cells, providing a mechanistic explanation for the importance of glycolysis in immune cell functions.<\/jats:p>","DOI":"10.4049\/jimmunol.1700042","type":"journal-article","created":{"date-parts":[[2018,7,20]],"date-time":"2018-07-20T16:56:02Z","timestamp":1532105762000},"page":"1400-1411","source":"Crossref","is-referenced-by-count":14,"title":["Mannose Metabolism Is Essential for Th1 Cell Differentiation and IFN-\u03b3 Production"],"prefix":"10.1093","volume":"201","author":[{"given":"Beata M","family":"Zygmunt","sequence":"first","affiliation":[{"name":"Department of Vaccinology and Applied Microbiology, Helmholtz Centre for Infection Research , 38124 Braunschweig ,","place":["Germany"]},{"name":"Wroclaw Research Center EIT+ , 54-066 Wroclaw ,","place":["Poland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9502-9911","authenticated-orcid":false,"given":"Agnieszka","family":"W\u0119grzyn","sequence":"additional","affiliation":[{"name":"Wroclaw Research Center EIT+ , 54-066 Wroclaw ,","place":["Poland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0130-7912","authenticated-orcid":false,"given":"Weronika","family":"Gajska","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, Faculty of Fundamental Problems of Technology, Wroclaw University of Technology , 50-377 Wroclaw ,","place":["Poland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0377-9198","authenticated-orcid":false,"given":"Tetyana","family":"Yevsa","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School , 30625 Hannover ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grzegorz","family":"Chodaczek","sequence":"additional","affiliation":[{"name":"Wroclaw Research Center EIT+ , 54-066 Wroclaw ,","place":["Poland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos A","family":"Guzm\u00e1n","sequence":"additional","affiliation":[{"name":"Department of Vaccinology and Applied Microbiology, Helmholtz Centre for Infection Research , 38124 Braunschweig ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2018,9,1]]},"reference":[{"key":"2025030417572117100_r1","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1146\/annurev-cellbio-092910-154237","article-title":"Aerobic glycolysis: meeting the metabolic requirements of cell proliferation","volume":"27","author":"Lunt","year":"2011","journal-title":"Annu. 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