{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T20:40:51Z","timestamp":1790887251887,"version":"4.1.0"},"reference-count":46,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2017,5,1]],"date-time":"2017-05-01T00:00:00Z","timestamp":1493596800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The scavenger receptor macrophage receptor with collagenous structure (MARCO) promotes protective innate immunity against bacterial and parasitic infections; however, its role in host immunity against fungal pathogens, including the major human opportunistic fungal pathogen Cryptococcus neoformans, remains unknown. Using a mouse model of C. neoformans infection, we demonstrated that MARCO deficiency leads to impaired fungal control during the afferent phase of cryptococcal infection. Diminished fungal containment in MARCO\u2212\/\u2212 mice was accompanied by impaired recruitment of Ly6Chigh monocytes and monocyte-derived dendritic cells (moDC) and lower moDC costimulatory maturation. The reduced recruitment and activation of mononuclear phagocytes in MARCO\u2212\/\u2212 mice was linked to diminished early expression of IFN-\u03b3 along with profound suppression of CCL2 and CCL7 chemokines, providing evidence for roles of MARCO in activation of the CCR2 axis during C. neoformans infection. Lastly, we found that MARCO was involved in C. neoformans phagocytosis by resident pulmonary macrophages and DC. We conclude that MARCO facilitates early interactions between C. neoformans and lung-resident cells and promotes the production of CCR2 ligands. In turn, this contributes to a more robust recruitment and activation of moDC that opposes rapid fungal expansion during the afferent phase of cryptococcal infection.<\/jats:p>","DOI":"10.4049\/jimmunol.1700057","type":"journal-article","created":{"date-parts":[[2017,3,16]],"date-time":"2017-03-16T00:50:20Z","timestamp":1489625420000},"page":"3548-3557","source":"Crossref","is-referenced-by-count":46,"title":["Scavenger Receptor MARCO Orchestrates Early Defenses and Contributes to Fungal Containment during Cryptococcal Infection"],"prefix":"10.1093","volume":"198","author":[{"given":"Jintao","family":"Xu","sequence":"first","affiliation":[{"name":"Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan Health System , Ann Arbor, MI 48109"},{"name":"Pulmonary Section, Medical Service, VA Ann Arbor Healthcare System, Department of Veterans Affairs Health System , Ann Arbor, MI 48105"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9799-3170","authenticated-orcid":false,"given":"Adam","family":"Flaczyk","sequence":"additional","affiliation":[{"name":"Pulmonary Section, Medical Service, VA Ann Arbor Healthcare System, Department of Veterans Affairs Health System , Ann Arbor, MI 48105"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lori M","family":"Neal","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan Health System , Ann Arbor, MI 48109"},{"name":"Pulmonary Section, Medical Service, VA Ann Arbor Healthcare System, Department of Veterans Affairs Health System , Ann Arbor, MI 48105"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3975-4996","authenticated-orcid":false,"given":"Zhenzong","family":"Fa","sequence":"additional","affiliation":[{"name":"Pulmonary Section, Medical Service, VA Ann Arbor Healthcare System, Department of Veterans Affairs Health System , Ann Arbor, MI 48105"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alison J","family":"Eastman","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan Health System , Ann Arbor, MI 48109"},{"name":"Pulmonary Section, Medical Service, VA Ann Arbor Healthcare System, Department of Veterans Affairs Health System , Ann Arbor, MI 48105"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antoni N","family":"Malachowski","sequence":"additional","affiliation":[{"name":"Pulmonary Section, Medical Service, VA Ann Arbor Healthcare System, Department of Veterans Affairs Health System , Ann Arbor, MI 48105"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daphne","family":"Cheng","sequence":"additional","affiliation":[{"name":"Pulmonary Section, Medical Service, VA Ann Arbor Healthcare System, Department of Veterans Affairs Health System , Ann Arbor, MI 48105"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3051-745X","authenticated-orcid":false,"given":"Bethany B","family":"Moore","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan Health System , Ann Arbor, MI 48109"},{"name":"Department of Microbiology and Immunology, University of Michigan Medical School , Ann Arbor, MI 48109"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5191-4847","authenticated-orcid":false,"given":"Jeffrey L","family":"Curtis","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan Health System , Ann Arbor, MI 48109"},{"name":"Pulmonary Section, Medical Service, VA Ann Arbor Healthcare System, Department of Veterans Affairs Health System , Ann Arbor, MI 48105"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John J","family":"Osterholzer","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan Health System , Ann Arbor, MI 48109"},{"name":"Pulmonary Section, Medical Service, VA Ann Arbor Healthcare System, Department of Veterans Affairs Health System , Ann Arbor, MI 48105"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7474-0843","authenticated-orcid":false,"given":"Michal A","family":"Olszewski","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan Health System , Ann Arbor, MI 48109"},{"name":"Pulmonary Section, Medical Service, VA Ann Arbor Healthcare System, Department of Veterans Affairs Health System , Ann Arbor, MI 48105"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2017,5,1]]},"reference":[{"key":"2025030615114295000_r1","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.2217\/fmb.10.93","article-title":"Mechanisms of cryptococcal virulence and persistence","volume":"5","author":"Olszewski","year":"2010","journal-title":"Future Microbiol."},{"key":"2025030615114295000_r2","doi-asserted-by":"crossref","first-page":"565","DOI":"10.2217\/fmb.14.132","article-title":"Host immunity to Cryptococcus neoformans","volume":"10","author":"Rohatgi","year":"2015","journal-title":"Future 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