{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T07:11:33Z","timestamp":1773904293474,"version":"3.50.1"},"reference-count":54,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2017,8,1]],"date-time":"2017-08-01T00:00:00Z","timestamp":1501545600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Secondhand smoke (SHS) exposure has been linked to the worsening of ongoing lung diseases. However, whether SHS exposure affects the manifestation and natural history of imminent pediatric muco-obstructive airway diseases such as cystic fibrosis remains unclear. To address these questions, we exposed Scnn1b transgenic (Scnn1b-Tg+) mice to SHS from postnatal day (PND) 3\u201321 and lung phenotypes were examined at PND22. Although a majority of filtered air (FA)-exposed Scnn1b-Tg+ (FA-Tg+) mice successfully cleared spontaneous bacterial infections by PND22, the SHS-exposed Scnn1b-Tg+ (SHS-Tg+) mice failed to resolve these infections. This defect was associated with suppressed antibacterial defenses, i.e., phagocyte recruitment, IgA secretion, and Muc5b expression. Whereas the FA-Tg+ mice exhibited marked mucus obstruction and Th2 responses, SHS-Tg+ mice displayed a dramatic suppression of these responses. Mechanistically, downregulated expression of IL-33, a stimulator of type II innate lymphoid cells, in lung epithelial cells was associated with suppression of neutrophil recruitment, IgA secretions, Th2 responses, and delayed bacterial clearance in SHS-Tg+ mice. Cessation of SHS exposure for 21 d restored previously suppressed responses, including phagocyte recruitment, IgA secretion, and mucous cell metaplasia. However, in contrast with FA-Tg+ mice, the SHS-Tg+ mice had pronounced epithelial necrosis, alveolar space consolidation, and lymphoid hyperplasia; indicating lagged unfavorable effects of early postnatal SHS exposure in later life. Collectively, our data show that early postnatal SHS exposure reversibly suppresses IL-33 levels in airspaces which, in turn, results in reduced neutrophil recruitment and diminished Th2 response. Our data indicate that household smoking may predispose neonates with muco-obstructive lung disease to bacterial exacerbations.<\/jats:p>","DOI":"10.4049\/jimmunol.1700144","type":"journal-article","created":{"date-parts":[[2017,7,1]],"date-time":"2017-07-01T00:30:27Z","timestamp":1498869027000},"page":"1170-1183","source":"Crossref","is-referenced-by-count":28,"title":["Early Postnatal Secondhand Smoke Exposure Disrupts Bacterial Clearance and Abolishes Immune Responses in Muco-Obstructive Lung Disease"],"prefix":"10.1093","volume":"199","author":[{"given":"Brandon W","family":"Lewis","sequence":"first","affiliation":[{"name":"Department of Comparative Biomedical Sciences, School of Veterinary Medicine, Louisiana State University , Baton Rouge, LA 70803"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Razia","family":"Sultana","sequence":"additional","affiliation":[{"name":"Department of Comparative Biomedical Sciences, School of Veterinary Medicine, Louisiana State University , Baton Rouge, LA 70803"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rahul","family":"Sharma","sequence":"additional","affiliation":[{"name":"National Hansen\u2019s Disease Program, School of Veterinary Medicine, Louisiana State University , Baton Rouge, LA 70803"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandra","family":"No\u00ebl","sequence":"additional","affiliation":[{"name":"Department of Comparative Biomedical Sciences, School of Veterinary Medicine, Louisiana State University , Baton Rouge, LA 70803"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ingeborg","family":"Langohr","sequence":"additional","affiliation":[{"name":"Department of Pathobiological Sciences, School of Veterinary Medicine, Louisiana State University , Baton Rouge, LA 70803"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sonika","family":"Patial","sequence":"additional","affiliation":[{"name":"Department of Comparative Biomedical Sciences, School of Veterinary Medicine, Louisiana State University , Baton Rouge, LA 70803"},{"name":"Department of Pathobiological Sciences, School of Veterinary Medicine, Louisiana State University , Baton Rouge, LA 70803"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arthur L","family":"Penn","sequence":"additional","affiliation":[{"name":"Department of Comparative Biomedical Sciences, School of Veterinary Medicine, Louisiana State University , Baton Rouge, LA 70803"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yogesh","family":"Saini","sequence":"additional","affiliation":[{"name":"Department of Comparative Biomedical Sciences, School of Veterinary Medicine, Louisiana State University , Baton Rouge, LA 70803"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2017,8,1]]},"reference":[{"key":"2025030614220832300_r1","volume-title":"Air Quality Criteria for Particulate Matter","author":"U.S. Environmental Protection Agency","year":"2004"},{"key":"2025030614220832300_r2","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1164\/rccm.200705-684ED","article-title":"Indoor air, passive smoking, and COPD","volume":"176","author":"Eisner","year":"2007","journal-title":"Am. 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