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In this article, we report that abnormal \u03b2-catenin expression in T cells drives a fatal neuroinflammatory disease in mice that is characterized by CNS infiltration of T cells, glial activation, and progressive loss of motor function. We show that enhanced \u03b2-catenin expression in T cells leads to aberrant and Th1-biased T cell activation, enhanced expression of integrin \u03b14\u03b21, and infiltration of activated T cells into the spinal cord, without affecting regulatory T cell function. Importantly, expression of \u03b2-catenin in mature naive T cells was sufficient to drive integrin \u03b14\u03b21 expression and CNS migration, whereas pharmacologic inhibition of integrin \u03b14\u03b21 reduced the abnormal T cell presence in the CNS of \u03b2-catenin\u2013expressing mice. Together, these results implicate deregulation of the Wnt\/\u03b2-catenin pathway in CNS inflammation and suggest novel therapeutic strategies for neuroinflammatory disorders.<\/jats:p>","DOI":"10.4049\/jimmunol.1700247","type":"journal-article","created":{"date-parts":[[2017,9,23]],"date-time":"2017-09-23T00:40:21Z","timestamp":1506127221000},"page":"3031-3041","source":"Crossref","is-referenced-by-count":23,"title":["Wnt\/\u03b2-Catenin Signaling Induces Integrin \u03b14\u03b21 in T Cells and Promotes a Progressive Neuroinflammatory Disease in Mice"],"prefix":"10.1093","volume":"199","author":[{"given":"Daniele","family":"Sorcini","sequence":"first","affiliation":[{"name":"Department of Medicine, University of Perugia , Perugia 06132,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Bruscoli","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Perugia , Perugia 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