{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T05:26:08Z","timestamp":1777353968835,"version":"3.51.4"},"reference-count":22,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2017,10,1]],"date-time":"2017-10-01T00:00:00Z","timestamp":1506816000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,10,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Several observations implicate a critical role for T cell dysregulation as a central problem in rheumatoid arthritis. We investigated a mechanism for suppressing T cell activation by stimulating a natural inhibitory receptor called leukocyte-associated Ig-like receptor-1 (LAIR-1). The collagen-induced arthritis (CIA) model and DR-1 transgenic mice were used to study the importance of LAIR-1 in autoimmune arthritis. Splenocytes from wild-type or LAIR-1\u2212\/\u2212 mice were stimulated with soluble anti-CD3 Ab in the presence or absence of \u03b11(II) and supernatants were collected for cytokine analysis. B6.DR1 mice were immunized with type II collagen\/CFA to induce arthritis and were treated with either the stimulatory mAb to LAIR-1 or a hamster IgG control. Finally, B6.DR1\/LAIR-1\u2212\/\u2212 and B6.DR1\/LAIR-1+\/+ mice were challenged for CIA and mean severity scores were recorded thrice weekly. Using splenocytes or purified CD4+ cells that were sufficient in LAIR-1, CD3-induced cytokine secretion was significantly suppressed in the presence of collagen, whereas LAIR-1\u2013deficient splenocytes had no attenuation. Treatment with a stimulatory mAb to LAIR-1 also significantly attenuated CIA in the LAIR+\/+ mice. When B6.DR1\/LAIR-1\u2212\/\u2212 mice were immunized with type II collagen they developed more severe arthritis and had a greater percentage of affected limbs than the wild-type mice. These data demonstrate that collagen can suppress the T cell cytokine response through the action of LAIR-1. Treatment with stimulating LAIR-1 Abs suppresses CIA whereas B6.DR1\/LAIR-1\u2212\/\u2212 mice develop more severe arthritis than wild-type controls. These data suggest that LAIR-1 may be a potential therapeutic target for suppressing rheumatoid arthritis.<\/jats:p>","DOI":"10.4049\/jimmunol.1700271","type":"journal-article","created":{"date-parts":[[2017,9,9]],"date-time":"2017-09-09T00:30:37Z","timestamp":1504917037000},"page":"2692-2700","source":"Crossref","is-referenced-by-count":22,"title":["The Role of Leukocyte-Associated Ig-like Receptor-1 in Suppressing Collagen-Induced Arthritis"],"prefix":"10.1093","volume":"199","author":[{"given":"Seunghyun","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Medicine, University of Tennessee Health Science Center , Memphis, TN 38163"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ellis R","family":"Easterling","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Tennessee Health Science Center , Memphis, TN 38163"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lauren C","family":"Price","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Tennessee Health Science Center , Memphis, TN 38163"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Savannah L","family":"Smith","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Tennessee Health Science Center , Memphis, TN 38163"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John E","family":"Coligan","sequence":"additional","affiliation":[{"name":"Receptor Cell Biology Section, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases , Rockville, MD 20852"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4080-4447","authenticated-orcid":false,"given":"Jeoung-Eun","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Tennessee Health Science Center , Memphis, TN 38163"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9260-7963","authenticated-orcid":false,"given":"David D","family":"Brand","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Tennessee Health Science Center , Memphis, TN 38163"},{"name":"Department of Microbiology, Immunology and Biochemistry, University of Tennessee Health Science Center , Memphis, TN 38163"},{"name":"Research Service, Veterans Affairs Medical Center , Memphis, TN 38104"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edward F","family":"Rosloniec","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Tennessee Health Science Center , Memphis, TN 38163"},{"name":"Research Service, Veterans Affairs Medical Center , Memphis, TN 38104"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John M","family":"Stuart","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Tennessee Health Science Center , Memphis, TN 38163"},{"name":"Research Service, Veterans Affairs Medical Center , Memphis, TN 38104"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew H","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Tennessee Health Science Center , Memphis, TN 38163"},{"name":"Research Service, Veterans Affairs Medical Center , Memphis, TN 38104"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linda K","family":"Myers","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Department of Pediatrics, University of Tennessee Health Science Center , Memphis, TN 38163"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2017,10,15]]},"reference":[{"key":"2025030614491565600_r1","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1189\/jlb.0907609","article-title":"The inhibitory collagen receptor LAIR-1 (CD305)","volume":"83","author":"Meyaard","year":"2008","journal-title":"J. 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