{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T06:38:12Z","timestamp":1789886292503,"version":"4.0.1"},"reference-count":87,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2017,9,1]],"date-time":"2017-09-01T00:00:00Z","timestamp":1504224000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The capacity of licensed vaccines to protect the ocular surface against infection is limited. Common ocular pathogens, such as HSV-1, are increasingly recognized as major contributors to visual morbidity worldwide. Humoral immunity is an essential correlate of protection against HSV-1 pathogenesis and ocular pathology, yet the ability of Ab to protect against HSV-1 is deemed limited due to the slow IgG diffusion rate in the healthy cornea. We show that a live-attenuated HSV-1 vaccine elicits humoral immune responses that are unparalleled by a glycoprotein subunit vaccine vis-\u00e0-vis Ab persistence and host protection. The live-attenuated vaccine was used to assess the impact of the immunization route on vaccine efficacy. The hierarchical rankings of primary immunization route with respect to efficacy were s.c. \u2265 mucosal &amp;gt; i.m. Prime-boost vaccination via sequential s.c. and i.m. administration yielded greater efficacy than any other primary immunization route alone. Moreover, our data support a role for complement in prophylactic protection, as evidenced by intracellular deposition of C3d in the corneal epithelium of vaccinated animals following challenge and delayed viral clearance in C3-deficient mice. We also identify that the neonatal Fc receptor (FcRn) is upregulated in the cornea following infection or injury concomitant with increased Ab perfusion. Lastly, selective small interfering RNA\u2013mediated knockdown of FcRn in the cornea impeded protection against ocular HSV-1 challenge in vaccinated mice. Collectively, these findings establish a novel mechanism of humoral protection in the eye involving FcRn and may facilitate vaccine and therapeutic development for other ocular surface diseases.<\/jats:p>","DOI":"10.4049\/jimmunol.1700316","type":"journal-article","created":{"date-parts":[[2017,8,1]],"date-time":"2017-08-01T00:40:24Z","timestamp":1501548024000},"page":"1898-1911","source":"Crossref","is-referenced-by-count":18,"title":["The Neonatal Fc Receptor and Complement Fixation Facilitate Prophylactic Vaccine-Mediated Humoral Protection against Viral Infection in the Ocular Mucosa"],"prefix":"10.1093","volume":"199","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8476-1784","authenticated-orcid":false,"given":"Derek J","family":"Royer","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, University of Oklahoma Health Sciences Center , Oklahoma City, OK 73104"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meghan M","family":"Carr","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, University of Oklahoma Health Sciences Center , Oklahoma City, OK 73104"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hem R","family":"Gurung","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, University of Oklahoma Health Sciences Center , Oklahoma City, OK 73104"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William P","family":"Halford","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology, Immunology, and Cell Biology, Southern Illinois University School of Medicine , Springfield, IL 62794"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1954-2478","authenticated-orcid":false,"given":"Daniel J J","family":"Carr","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, University of Oklahoma Health Sciences Center , Oklahoma City, OK 73104"},{"name":"Department of Microbiology and Immunology, University of Oklahoma Health Sciences Center , Oklahoma City, OK 73104"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2017,9,1]]},"reference":[{"key":"2025030614270782700_r1","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1146\/annurev-immunol-032414-112315","article-title":"Exploiting mucosal immunity for antiviral vaccines","volume":"34","author":"Iwasaki","year":"2016","journal-title":"Annu. Rev. Immunol."},{"key":"2025030614270782700_r2","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.1080\/21645515.2015.1114195","article-title":"Induction of mucosal immunity through systemic immunization: phantom or reality?","volume":"12","author":"Su","year":"2016","journal-title":"Hum. Vaccin. Immunother."},{"key":"2025030614270782700_r3","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1038\/mi.2010.55","article-title":"Topical immunization strategies","volume":"3","author":"Czerkinsky","year":"2010","journal-title":"Mucosal Immunol."},{"key":"2025030614270782700_r4","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1038\/nri1777","article-title":"Mucosal vaccines: the promise and the challenge","volume":"6","author":"Neutra","year":"2006","journal-title":"Nat. Rev. Immunol."},{"key":"2025030614270782700_r5","doi-asserted-by":"crossref","first-page":"6883","DOI":"10.4049\/jimmunol.0901466","article-title":"What role does the route of immunization play in the generation of protective immunity against mucosal pathogens?","volume":"183","author":"Belyakov","year":"2009","journal-title":"J. Immunol."},{"key":"2025030614270782700_r6","volume-title":"The Eye: Basic Sciences in Practice","author":"Forrester","year":"2016","edition":"4th"},{"key":"2025030614270782700_r7","first-page":"214","article-title":"Corneal blindness: a global perspective","volume":"79","author":"Whitcher","year":"2001","journal-title":"Bull. World Health Organ."},{"key":"2025030614270782700_r8","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1586\/17469899.2015.1004315","article-title":"The current state of vaccine development for ocular HSV-1 infection","volume":"10","author":"Royer","year":"2015","journal-title":"Expert Rev. Ophthalmol."},{"key":"2025030614270782700_r9","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1016\/j.survophthal.2012.01.005","article-title":"Herpes simplex epithelial and stromal keratitis: an epidemiologic update","volume":"57","author":"Farooq","year":"2012","journal-title":"Surv. Ophthalmol."},{"key":"2025030614270782700_r10","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1001\/archopht.121.1.108","article-title":"Prevention of herpes simplex virus eye disease: a cost-effectiveness analysis","volume":"121","author":"Lairson","year":"2003","journal-title":"Arch. Ophthalmol."},{"key":"2025030614270782700_r11","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1016\/S0264-410X(00)00242-5","article-title":"Local and systemic inoculation of DNA or protein gB1s-based vaccines induce a protective immunity against rabbit ocular HSV-1 infection","volume":"19","author":"Caselli","year":"2000","journal-title":"Vaccine"},{"key":"2025030614270782700_r12","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1086\/514049","article-title":"Efficacy of a recombinant glycoprotein D subunit vaccine on the development of primary and recurrent ocular infection with herpes simplex virus type 1 in mice","volume":"176","author":"Keadle","year":"1997","journal-title":"J. Infect. Dis."},{"key":"2025030614270782700_r13","doi-asserted-by":"crossref","first-page":"2561","DOI":"10.4049\/jimmunol.0902322","article-title":"A novel HLA (HLA-A*0201) transgenic rabbit model for preclinical evaluation of human CD8+ T cell epitope-based vaccines against ocular herpes","volume":"184","author":"Chentoufi","year":"2010","journal-title":"J. Immunol."},{"key":"2025030614270782700_r14","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0264-410X(97)00164-3","article-title":"Protection from primary infection and establishment of latency by vaccination with a herpes simplex virus type 1 recombinant deficient in the virion host shutoff (vhs) function","volume":"16","author":"Walker","year":"1998","journal-title":"Vaccine"},{"key":"2025030614270782700_r15","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1016\/j.vaccine.2004.08.019","article-title":"Local and systemic B cell and Th1 responses induced following ocular mucosal delivery of multiple epitopes of herpes simplex virus type 1 glycoprotein D together with cytosine-phosphate-guanine adjuvant","volume":"23","author":"Nesburn","year":"2005","journal-title":"Vaccine"},{"key":"2025030614270782700_r16","doi-asserted-by":"crossref","first-page":"4643","DOI":"10.1167\/iovs.07-0356","article-title":"Protective immunity against ocular herpes infection and disease induced by highly immunogenic self-adjuvanting glycoprotein D lipopeptide vaccines","volume":"48","author":"Bettahi","year":"2007","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"2025030614270782700_r17","doi-asserted-by":"crossref","first-page":"5514","DOI":"10.1128\/JVI.00517-16","article-title":"A highly efficacious herpes simplex virus 1 vaccine blocks viral pathogenesis and prevents corneal immunopathology via humoral immunity","volume":"90","author":"Royer","year":"2016","journal-title":"J. Virol."},{"key":"2025030614270782700_r18","doi-asserted-by":"crossref","first-page":"e02342","DOI":"10.1128\/JVI.02342-16","article-title":"Impact of type 1 interferon on the safety and immunogenicity of an experimental live-attenuated herpes simplex virus type 1 vaccine in mice","volume":"91","author":"Royer","year":"2017","journal-title":"J. Virol."},{"key":"2025030614270782700_r19","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1093\/infdis\/jit651","article-title":"Correlate of immune protection against HSV-1 genital disease in vaccinated women","volume":"209","author":"Belshe","year":"2014","journal-title":"J. Infect. Dis."},{"key":"2025030614270782700_r20","volume-title":"Vaccines","author":"Plotkin","year":"2013","edition":"6th"},{"key":"2025030614270782700_r21","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/0002-9394(75)90882-X","article-title":"Immunoglobulins in the human cornea","volume":"80","author":"Allansmith","year":"1975","journal-title":"Am. J. Ophthalmol."},{"key":"2025030614270782700_r22","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1128\/iai.60.3.885-891.1992","article-title":"Kinetics of serum, tear, and corneal antibody responses in resistant and susceptible mice intracorneally infected with Pseudomonas aeruginosa","volume":"60","author":"Preston","year":"1992","journal-title":"Infect. Immun."},{"key":"2025030614270782700_r23","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1038\/nri2155","article-title":"FcRn: the neonatal Fc receptor comes of age","volume":"7","author":"Roopenian","year":"2007","journal-title":"Nat. Rev. Immunol."},{"key":"2025030614270782700_r24","doi-asserted-by":"crossref","first-page":"e4729","DOI":"10.1371\/journal.pone.0004729","article-title":"Genetic variation and population substructure in outbred CD-1 mice: implications for genome-wide association studies","volume":"4","author":"Aldinger","year":"2009","journal-title":"PLoS One"},{"key":"2025030614270782700_r25","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.virol.2012.07.018","article-title":"Factors affecting herpes simplex virus reactivation from the explanted mouse brain","volume":"433","author":"Yao","year":"2012","journal-title":"Virology"},{"key":"2025030614270782700_r26","doi-asserted-by":"crossref","first-page":"e17748","DOI":"10.1371\/journal.pone.0017748","article-title":"A live-attenuated HSV-2 ICP0 virus elicits 10 to 100 times greater protection against genital herpes than a glycoprotein D subunit vaccine","volume":"6","author":"Halford","year":"2011","journal-title":"PLoS One"},{"key":"2025030614270782700_r27","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1093\/infdis\/jiu177","article-title":"Better neutralization of herpes simplex virus type 1 (HSV-1) than HSV-2 by antibody from recipients of GlaxoSmithKline HSV-2 glycoprotein D2 subunit vaccine","volume":"210","author":"Awasthi","year":"2014","journal-title":"J. Infect. Dis."},{"key":"2025030614270782700_r28","doi-asserted-by":"crossref","first-page":"6785","DOI":"10.1167\/iovs.12-10400","article-title":"CXCL1-deficient mice are highly sensitive to Pseudomonas aeruginosa but not herpes simplex virus type 1 corneal infection","volume":"53","author":"Bryant-Hudson","year":"2012","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"2025030614270782700_r29","doi-asserted-by":"crossref","first-page":"8189","DOI":"10.1167\/iovs.14-15595","article-title":"Monitoring of strain-dependent responsiveness to TLR activation in the mouse anterior segment using SD-OCT","volume":"55","author":"Downie","year":"2014","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"2025030614270782700_r30","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1084\/jem.20091385","article-title":"VEGF-A expression by HSV-1-infected cells drives corneal lymphangiogenesis","volume":"207","author":"Wuest","year":"2010","journal-title":"J. Exp. Med."},{"key":"2025030614270782700_r31","doi-asserted-by":"crossref","first-page":"3763","DOI":"10.1167\/iovs.15-16900","article-title":"Granulocytes in ocular HSV-1 infection: opposing roles of mast cells and neutrophils","volume":"56","author":"Royer","year":"2015","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"2025030614270782700_r32","doi-asserted-by":"crossref","first-page":"2338","DOI":"10.4049\/jimmunol.1600574","article-title":"Herpesvirus-associated lymphadenitis distorts fibroblastic reticular cell microarchitecture and attenuates CD8 T cell responses to neurotropic infection in mice lacking the STING-IFN\u03b1\/\u03b2 defense pathways","volume":"197","author":"Royer","year":"2016","journal-title":"J. Immunol."},{"key":"2025030614270782700_r33","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1038\/mi.2015.124","article-title":"A STING-dependent innate-sensing pathway mediates resistance to corneal HSV-1 infection via upregulation of the antiviral effector tetherin","volume":"9","author":"Royer","year":"2016","journal-title":"Mucosal Immunol."},{"key":"2025030614270782700_r34","doi-asserted-by":"crossref","first-page":"1903","DOI":"10.1056\/NEJMoa066092","article-title":"Duration of humoral immunity to common viral and vaccine antigens","volume":"357","author":"Amanna","year":"2007","journal-title":"N. Engl. J. Med."},{"key":"2025030614270782700_r35","doi-asserted-by":"crossref","first-page":"1930","DOI":"10.1016\/j.ophtha.2010.07.010","article-title":"Corneal sensation and subbasal nerve alterations in patients with herpes simplex keratitis: an in vivo confocal microscopy study","volume":"117","author":"Hamrah","year":"2010","journal-title":"Ophthalmology"},{"key":"2025030614270782700_r36","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1167\/iovs.14-15596","article-title":"Degeneration and regeneration of corneal nerves in response to HSV-1 infection","volume":"56","author":"Chucair-Elliott","year":"2015","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"2025030614270782700_r37","doi-asserted-by":"crossref","first-page":"314","DOI":"10.3129\/i09-018","article-title":"Persistent pupillary dilation in herpes simplex uveitis","volume":"44","author":"Goldstein","year":"2009","journal-title":"Can. J. Ophthalmol."},{"key":"2025030614270782700_r38","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1046\/j.1365-2249.2002.01808.x","article-title":"Penetration of engineered antibody fragments into the eye","volume":"128","author":"Thiel","year":"2002","journal-title":"Clin. Exp. Immunol."},{"key":"2025030614270782700_r39","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1208\/s12248-010-9183-3","article-title":"Ocular drug delivery","volume":"12","author":"Gaudana","year":"2010","journal-title":"AAPS J."},{"key":"2025030614270782700_r40","first-page":"1519","article-title":"Diffusion of immunoglobulin G from the vascular compartment into the normal rabbit cornea","volume":"31","author":"Verhagen","year":"1990","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"2025030614270782700_r41","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2017.04.001","article-title":"Rheostatic functions of mast cells in the control of innate and adaptive immune responses","volume-title":"Trends Immunol.","author":"Frossi","year":"2017"},{"key":"2025030614270782700_r42","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1385\/IR:36:1:197","article-title":"Complement-mediated activation of the adaptive immune responses: role of C3d in linking the innate and adaptive immunity","volume":"36","author":"Toapanta","year":"2006","journal-title":"Immunol. Res."},{"key":"2025030614270782700_r43","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1186\/1746-1596-7-109","article-title":"The continual presence of C3d but not IgG glomerular capillary deposition in stage I idiopathic membranous nephropathy in patients receiving corticosteroid treatment","volume":"7","author":"Zhang","year":"2012","journal-title":"Diagn. Pathol."},{"key":"2025030614270782700_r44","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1038\/nrm.2016.80","article-title":"Tight junctions: from simple barriers to multifunctional molecular gates","volume":"17","author":"Zihni","year":"2016","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"2025030614270782700_r45","doi-asserted-by":"crossref","first-page":"2025","DOI":"10.1167\/iovs.07-0871","article-title":"Mapping of the neonatal Fc receptor in the rodent eye","volume":"49","author":"Kim","year":"2008","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"2025030614270782700_r46","doi-asserted-by":"crossref","first-page":"1607","DOI":"10.1167\/iovs.13-12574","article-title":"Expression of neonatal Fc receptor in the eye","volume":"55","author":"Powner","year":"2014","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"2025030614270782700_r47","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1038\/337184a0","article-title":"An Fc receptor structurally related to MHC class I antigens","volume":"337","author":"Simister","year":"1989","journal-title":"Nature"},{"key":"2025030614270782700_r48","doi-asserted-by":"crossref","first-page":"3266","DOI":"10.4049\/jimmunol.166.5.3266","article-title":"MHC class I-related neonatal Fc receptor for IgG is functionally expressed in monocytes, intestinal macrophages, and dendritic cells","volume":"166","author":"Zhu","year":"2001","journal-title":"J. Immunol."},{"key":"2025030614270782700_r49","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1038\/mi.2012.46","article-title":"IFN-\u03b1-driven CCL2 production recruits inflammatory monocytes to infection site in mice","volume":"6","author":"Conrady","year":"2013","journal-title":"Mucosal Immunol."},{"key":"2025030614270782700_r50","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1111\/j.1600-065X.2010.00912.x","article-title":"Mechanisms that determine plasma cell lifespan and the duration of humoral immunity","volume":"236","author":"Amanna","year":"2010","journal-title":"Immunol. Rev."},{"key":"2025030614270782700_r51","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1056\/NEJMoa1103151","article-title":"Efficacy results of a trial of a herpes simplex vaccine","volume":"366","author":"Belshe","year":"2012","journal-title":"N. Engl. J. Med."},{"key":"2025030614270782700_r52","doi-asserted-by":"crossref","first-page":"2087","DOI":"10.1056\/NEJMoa1501184","article-title":"Efficacy of an adjuvanted herpes zoster subunit vaccine in older adults","volume":"372","author":"Lal","year":"2015","journal-title":"N. Engl. J. Med."},{"key":"2025030614270782700_r53","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1586\/14760584.2014.910121","article-title":"Antigenic breadth: a missing ingredient in HSV-2 subunit vaccines?","volume":"13","author":"Halford","year":"2014","journal-title":"Expert Rev. Vaccines"},{"key":"2025030614270782700_r54","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1046\/j.1365-2893.2003.00400.x","article-title":"Hepatitis B vaccine -- do we need boosters?","volume":"10","author":"Banatvala","year":"2003","journal-title":"J. Viral Hepat."},{"key":"2025030614270782700_r55","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/S0014-4835(81)80043-7","article-title":"Immunocytochemical localization of IgA in the mouse cornea","volume":"32","author":"Hazlett","year":"1981","journal-title":"Exp. Eye Res."},{"key":"2025030614270782700_r56","first-page":"947","article-title":"The dynamics of IgG in the cornea","volume":"18","author":"Allansmith","year":"1979","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"2025030614270782700_r57","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1007\/BF00920226","article-title":"Diffusion of immunoglobulins into rabbit cornea after subconjunctival injection: experimental demonstration and mathematical model","volume":"231","author":"Osusky","year":"1993","journal-title":"Graefes Arch. Clin. Exp. Ophthalmol."},{"key":"2025030614270782700_r58","doi-asserted-by":"crossref","first-page":"4390","DOI":"10.1167\/iovs.07-0770","article-title":"The ocular surface: the challenge to enable and protect vision: the Friedenwald lecture","volume":"48","author":"Gipson","year":"2007","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"2025030614270782700_r59","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1038\/sj.eye.6700617","article-title":"Immune defense at the ocular surface","volume":"17","author":"Akpek","year":"2003","journal-title":"Eye (Lond.)"},{"key":"2025030614270782700_r60","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1111\/j.1469-7580.2005.00394.x","article-title":"The role of eye-associated lymphoid tissue in corneal immune protection","volume":"206","author":"Knop","year":"2005","journal-title":"J. Anat."},{"key":"2025030614270782700_r61","first-page":"294","article-title":"Kinetics of immunoglobulin appearance at the ocular surface","volume":"2","author":"Hazlett","year":"1989","journal-title":"Reg. Immunol."},{"key":"2025030614270782700_r62","first-page":"910","article-title":"Secretory IgA inhibits Pseudomonas aeruginosa binding to cornea and protects against keratitis","volume":"38","author":"Masinick","year":"1997","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"2025030614270782700_r63","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1128\/iai.37.1.374-377.1982","article-title":"Herpes simplex virus-specific serum immunoglobulin a: detection in patients with primary or recurrent herpes infections and in healthy adults","volume":"37","author":"Friedman","year":"1982","journal-title":"Infect. Immun."},{"key":"2025030614270782700_r64","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1086\/515611","article-title":"Cervical antibody responses to a herpes simplex virus type 2 glycoprotein subunit vaccine","volume":"178","author":"Ashley","year":"1998","journal-title":"J. Infect. Dis."},{"key":"2025030614270782700_r65","doi-asserted-by":"crossref","first-page":"e06054","DOI":"10.7554\/eLife.06054","article-title":"Herpes simplex type 2 virus deleted in glycoprotein D protects against vaginal, skin and neural disease","volume":"4","author":"Petro","year":"2015","journal-title":"eLife"},{"key":"2025030614270782700_r66","first-page":"451","article-title":"The human cornea proteome: bioinformatic analyses indicate import of plasma proteins into the cornea","volume":"12","author":"Karring","year":"2006","journal-title":"Mol. Vis."},{"key":"2025030614270782700_r67","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/S0014-4835(65)80052-5","article-title":"The distribution and movement of serum albumin in the cornea","volume":"4","author":"Maurice","year":"1965","journal-title":"Exp. Eye Res."},{"key":"2025030614270782700_r68","doi-asserted-by":"crossref","first-page":"4983","DOI":"10.1021\/bi052628y","article-title":"Albumin binding to FcRn: distinct from the FcRn-IgG interaction","volume":"45","author":"Chaudhury","year":"2006","journal-title":"Biochemistry"},{"key":"2025030614270782700_r69","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1172\/JCI6968","article-title":"Bidirectional FcRn-dependent IgG transport in a polarized human intestinal epithelial cell line","volume":"104","author":"Dickinson","year":"1999","journal-title":"J. Clin. Invest."},{"key":"2025030614270782700_r70","first-page":"1538","article-title":"Analysis of human corneal IgG by isoelectric focusing","volume":"29","author":"Waldrep","year":"1988","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"2025030614270782700_r71","doi-asserted-by":"crossref","first-page":"18406","DOI":"10.1073\/pnas.1115348108","article-title":"Intracellular neutralization of viral infection in polarized epithelial cells by neonatal Fc receptor (FcRn)-mediated IgG transport","volume":"108","author":"Bai","year":"2011","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2025030614270782700_r72","doi-asserted-by":"crossref","first-page":"4388","DOI":"10.1073\/pnas.1012861108","article-title":"Transfer of IgG in the female genital tract by MHC class I-related neonatal Fc receptor (FcRn) confers protective immunity to vaginal infection","volume":"108","author":"Li","year":"2011","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2025030614270782700_r73","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.molimm.2017.01.004","article-title":"Complement\u2019s hidden arsenal: New insights and novel functions inside the cell","volume":"84","author":"Liszewski","year":"2017","journal-title":"Mol. Immunol."},{"key":"2025030614270782700_r74","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1038\/nri3761","article-title":"Complement--tapping into new sites and effector systems","volume":"14","author":"Kolev","year":"2014","journal-title":"Nat. Rev. Immunol."},{"key":"2025030614270782700_r75","doi-asserted-by":"crossref","first-page":"1256070","DOI":"10.1126\/science.1256070","article-title":"Intracellular sensing of complement C3 activates cell autonomous immunity","volume":"345","author":"Tam","year":"2014","journal-title":"Science"},{"key":"2025030614270782700_r76","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1172\/JCI89412","article-title":"A C3(H20) recycling pathway is a component of the intracellular complement system","volume":"127","author":"Elvington","year":"2017","journal-title":"J. Clin. Invest."},{"key":"2025030614270782700_r77","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fimmu.2017.00001","article-title":"Keeping it all going-complement meets metabolism","volume":"8","author":"Kolev","year":"2017","journal-title":"Front. Immunol."},{"key":"2025030614270782700_r78","doi-asserted-by":"crossref","first-page":"12708","DOI":"10.1073\/pnas.96.22.12708","article-title":"Humoral response to herpes simplex virus is complement-dependent","volume":"96","author":"Da Costa","year":"1999","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2025030614270782700_r79","doi-asserted-by":"crossref","first-page":"5363","DOI":"10.4049\/jimmunol.171.10.5363","article-title":"Myeloid C3 determines induction of humoral responses to peripheral herpes simplex virus infection","volume":"171","author":"Verschoor","year":"2003","journal-title":"J. Immunol."},{"key":"2025030614270782700_r80","doi-asserted-by":"crossref","first-page":"6845","DOI":"10.1016\/j.vaccine.2009.09.017","article-title":"Immunization with HSV-1 glycoprotein C prevents immune evasion from complement and enhances the efficacy of an HSV-1 glycoprotein D subunit vaccine","volume":"27","author":"Awasthi","year":"2009","journal-title":"Vaccine"},{"key":"2025030614270782700_r81","doi-asserted-by":"crossref","first-page":"3239","DOI":"10.1128\/JVI.02509-10","article-title":"The herpes simplex virus 1 IgG fc receptor blocks antibody-mediated complement activation and antibody-dependent cellular cytotoxicity in vivo","volume":"85","author":"Lubinski","year":"2011","journal-title":"J. Virol."},{"key":"2025030614270782700_r82","doi-asserted-by":"crossref","first-page":"1637","DOI":"10.1084\/jem.190.11.1637","article-title":"In vivo role of complement-interacting domains of herpes simplex virus type 1 glycoprotein gC","volume":"190","author":"Lubinski","year":"1999","journal-title":"J. Exp. Med."},{"key":"2025030614270782700_r83","doi-asserted-by":"crossref","first-page":"e88529","DOI":"10.1172\/jci.insight.88529","article-title":"HSV-2 \u0394gD elicits Fc\u03b3R-effector antibodies that protect against clinical isolates","volume":"1","author":"Petro","year":"2016","journal-title":"JCI Insight"},{"key":"2025030614270782700_r84","doi-asserted-by":"crossref","first-page":"19985","DOI":"10.1073\/pnas.1014074107","article-title":"Antibodies mediate intracellular immunity through tripartite motif-containing 21 (TRIM21)","volume":"107","author":"Mallery","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2025030614270782700_r85","doi-asserted-by":"crossref","first-page":"2999","DOI":"10.4049\/jimmunol.179.5.2999","article-title":"NF-\u03baB signaling regulates functional expression of the MHC class I-related neonatal Fc receptor for IgG via intronic binding sequences","volume":"179","author":"Liu","year":"2007","journal-title":"J. Immunol."},{"key":"2025030614270782700_r86","doi-asserted-by":"crossref","first-page":"449","DOI":"10.4049\/jimmunol.181.1.449","article-title":"Activation of the JAK\/STAT-1 signaling pathway by IFN-gamma can down-regulate functional expression of the MHC class I-related neonatal Fc receptor for IgG","volume":"181","author":"Liu","year":"2008","journal-title":"J. Immunol."},{"key":"2025030614270782700_r87","doi-asserted-by":"crossref","first-page":"15614","DOI":"10.1073\/pnas.1413550111","article-title":"Antibody persistence and T-cell balance: two key factors confronting HIV vaccine development","volume":"111","author":"Lewis","year":"2014","journal-title":"Proc. Natl. Acad. Sci. USA"}],"container-title":["The Journal of Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/199\/5\/1898\/61582203\/ji1700316.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/199\/5\/1898\/61582203\/ji1700316.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,6]],"date-time":"2025-03-06T16:22:17Z","timestamp":1741278137000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jimmunol\/article\/199\/5\/1898\/7974764"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,9,1]]},"references-count":87,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2017,9,1]]}},"URL":"https:\/\/doi.org\/10.4049\/jimmunol.1700316","relation":{},"ISSN":["0022-1767","1550-6606"],"issn-type":[{"value":"0022-1767","type":"print"},{"value":"1550-6606","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2017,9]]},"published":{"date-parts":[[2017,9,1]]}}}