{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T01:11:10Z","timestamp":1790471470037,"version":"4.1.0"},"reference-count":30,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2017,9,1]],"date-time":"2017-09-01T00:00:00Z","timestamp":1504224000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The female reproductive tract (FRT) is one of the major mucosal invasion sites for HIV-1. This site has been neglected in previous HIV-1 vaccine studies. Immune responses in the FRT after systemic vaccination remain to be characterized. Using a modified vaccinia virus Ankara (MVA) as a vaccine model, we characterized specific immune responses in all compartments of the FRT of nonhuman primates after systemic vaccination. Memory T cells were preferentially found in the lower tract (vagina and cervix), whereas APCs and innate lymphoid cells were mainly located in the upper tract (uterus and fallopian tubes). This compartmentalization of immune cells in the FRT was supported by transcriptomic analyses and a correlation network. Polyfunctional MVA-specific CD8+ T cells were detected in the blood, lymph nodes, vagina, cervix, uterus, and fallopian tubes. Anti-MVA IgG and IgA were detected in cervicovaginal fluid after a second vaccine dose. Thus, systemic vaccination with an MVA vector elicits cellular and Ab responses in the FRT.<\/jats:p>","DOI":"10.4049\/jimmunol.1700320","type":"journal-article","created":{"date-parts":[[2017,8,1]],"date-time":"2017-08-01T00:40:24Z","timestamp":1501548024000},"page":"1923-1932","source":"Crossref","is-referenced-by-count":18,"title":["Modified Vaccinia Virus Ankara Vector Induces Specific Cellular and Humoral Responses in the Female Reproductive Tract, the Main HIV Portal of Entry"],"prefix":"10.1093","volume":"199","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8932-0171","authenticated-orcid":false,"given":"Romain","family":"Marlin","sequence":"first","affiliation":[{"name":"Immunologie des Infections Virales et des Maladies Auto-immunes (ImVA)\/Infrastructure Nationale pour la Mod\u00e9lisation des Maladies Infectieuses Humaines et les Th\u00e9rapies Innovantes (IDMIT)\/Commissariat \u00e0 l\u2019Energie Atomique et aux Energies Alternatives (CEA)\/Direction de la Recherche Fondamentale (DRF)\/Institut des Maladies Emergentes et des Traitements Innovants (IMETI), Universit\u00e9 Paris-Sud, INSERM U1184 , 92265 Fontenay-Aux-Roses,","place":["France"]},{"name":"Mucosal Innate Immunity and Sexually Transmitted Infections Control Group, Department of Virology, Institut Pasteur , 75015 Paris,","place":["France"]},{"name":"Vaccine Research Institute, Henri Mondor Hospital , 94010 Cr\u00e9teil,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-Th\u00e9r\u00e8se","family":"Nugeyre","sequence":"additional","affiliation":[{"name":"Immunologie des Infections Virales et des Maladies Auto-immunes (ImVA)\/Infrastructure Nationale pour la Mod\u00e9lisation des Maladies Infectieuses Humaines et les Th\u00e9rapies Innovantes (IDMIT)\/Commissariat \u00e0 l\u2019Energie Atomique et aux Energies Alternatives (CEA)\/Direction de la Recherche Fondamentale (DRF)\/Institut des Maladies Emergentes et des Traitements Innovants (IMETI), Universit\u00e9 Paris-Sud, INSERM U1184 , 92265 Fontenay-Aux-Roses,","place":["France"]},{"name":"Mucosal Innate Immunity and Sexually Transmitted Infections Control Group, Department of Virology, Institut Pasteur , 75015 Paris,","place":["France"]},{"name":"Vaccine Research Institute, Henri Mondor Hospital , 94010 Cr\u00e9teil,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Tchitchek","sequence":"additional","affiliation":[{"name":"Immunologie des Infections Virales et des Maladies Auto-immunes (ImVA)\/Infrastructure Nationale pour la Mod\u00e9lisation des Maladies Infectieuses Humaines et les Th\u00e9rapies Innovantes (IDMIT)\/Commissariat \u00e0 l\u2019Energie Atomique et aux Energies Alternatives (CEA)\/Direction de la Recherche Fondamentale (DRF)\/Institut des Maladies Emergentes et des Traitements Innovants (IMETI), Universit\u00e9 Paris-Sud, INSERM U1184 , 92265 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M\u00e9decine, Universit\u00e9 Paris-Est, INSERM U955 , 94010 Cr\u00e9teil,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6939-8721","authenticated-orcid":false,"given":"Fahd","family":"Benjelloun","sequence":"additional","affiliation":[{"name":"Immunologie des Infections Virales et des Maladies Auto-immunes (ImVA)\/Infrastructure Nationale pour la Mod\u00e9lisation des Maladies Infectieuses Humaines et les Th\u00e9rapies Innovantes (IDMIT)\/Commissariat \u00e0 l\u2019Energie Atomique et aux Energies Alternatives (CEA)\/Direction de la Recherche Fondamentale (DRF)\/Institut des Maladies Emergentes et des Traitements Innovants (IMETI), Universit\u00e9 Paris-Sud, INSERM U1184 , 92265 Fontenay-Aux-Roses,","place":["France"]},{"name":"Mucosal Innate Immunity and Sexually Transmitted Infections Control Group, Department of Virology, Institut Pasteur , 75015 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