{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T04:01:53Z","timestamp":1778126513626,"version":"3.51.4"},"reference-count":25,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2017,10,1]],"date-time":"2017-10-01T00:00:00Z","timestamp":1506816000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,10,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>IFN-\u03b3\u2013inducible protein 16 (IFI16) is an immunological DNA sensor proposed to act in the cyclic GMP\u2013AMP synthase\u2013stimulator of IFN genes pathway. Because mice do not have a clear ortholog of IFI16, this system is not suitable for genetic studies of IFI16. In this study, we have compared the dependency on IFI16, cyclic GMP\u2013AMP synthase, and stimulator of IFN genes for type I IFN induction by a panel of pathogenic bacteria and DNA viruses. The IFN response induced by HSV-2 was particularly dependent on IFI16. In a cohort of patients with genital herpes and healthy controls, the minor G allele of the IFI16 single nucleotide polymorphism rs2276404 was associated with resistance to infection. Furthermore, the combination of this allele with the C allele of rs1417806 was significantly overrepresented in uninfected individuals. Cells from individuals with the protective GC haplotype expressed higher levels of IFI16 and induced more IFN-\u03b2 upon HSV-2 infection. These data provide genetic evidence for a role for IFI16 in protection against genital herpes.<\/jats:p>","DOI":"10.4049\/jimmunol.1700385","type":"journal-article","created":{"date-parts":[[2017,9,12]],"date-time":"2017-09-12T00:40:28Z","timestamp":1505176828000},"page":"2613-2617","source":"Crossref","is-referenced-by-count":20,"title":["Cutting Edge: Genetic Association between IFI16 Single Nucleotide Polymorphisms and Resistance to Genital Herpes Correlates with IFI16 Expression Levels and HSV-2\u2013Induced IFN-\u03b2 Expression"],"prefix":"10.1093","volume":"199","author":[{"given":"Kristina","family":"Eriksson","sequence":"first","affiliation":[{"name":"Department of Rheumatology and Inflammation Research, University of Gothenburg , 40530 Gothenburg,","place":["Sweden"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandra","family":"Svensson","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Inflammation Research, University of Gothenburg , 40530 Gothenburg,","place":["Sweden"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alon S","family":"Hait","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Aarhus University Hospital , 8200 Aarhus,","place":["Denmark"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kerstin","family":"Schl\u00fcter","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Inflammation Research, University of Gothenburg , 40530 Gothenburg,","place":["Sweden"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8423-8566","authenticated-orcid":false,"given":"Petra","family":"Tunb\u00e4ck","sequence":"additional","affiliation":[{"name":"Department of Dermatovenereology, Sahlgrenska University Hospital , 41345 Gothenburg,","place":["Sweden"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Inger","family":"Nordstr\u00f6m","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Inflammation Research, University of Gothenburg , 40530 Gothenburg,","place":["Sweden"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2950-5670","authenticated-orcid":false,"given":"Leonid","family":"Padyukov","sequence":"additional","affiliation":[{"name":"Rheumatology Unit, Department of Medicine, Karolinska University Hospital , Solna, 17176 Stockholm,","place":["Sweden"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan-\u00c5ke","family":"Liljeqvist","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, University of Gothenburg , 41346 Gothenborg,","place":["Sweden"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Trine H","family":"Mogensen","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Aarhus University Hospital , 8200 Aarhus,","place":["Denmark"]},{"name":"Department of Biomedicine, Aarhus University , 8000 Aarhus,","place":["Denmark"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9180-4060","authenticated-orcid":false,"given":"S\u00f8ren R","family":"Paludan","sequence":"additional","affiliation":[{"name":"Department of Biomedicine, Aarhus University , 8000 Aarhus,","place":["Denmark"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2017,10,15]]},"reference":[{"key":"2025030614490863300_r1","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1016\/j.immuni.2013.05.004","article-title":"Immune sensing of DNA","volume":"38","author":"Paludan","year":"2013","journal-title":"Immunity"},{"key":"2025030614490863300_r2","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1126\/science.1232458","article-title":"Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathway","volume":"339","author":"Sun","year":"2013","journal-title":"Science"},{"key":"2025030614490863300_r3","doi-asserted-by":"crossref","first-page":"1390","DOI":"10.1126\/science.1244040","article-title":"Pivotal roles of cGAS-cGAMP signaling in antiviral defense and immune adjuvant effects","volume":"341","author":"Li","year":"2013","journal-title":"Science"},{"key":"2025030614490863300_r4","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1126\/science.1229963","article-title":"Cyclic GMP-AMP is an endogenous second messenger in innate immune signaling by cytosolic DNA","volume":"339","author":"Wu","year":"2013","journal-title":"Science"},{"key":"2025030614490863300_r5","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1038\/ni.1932","article-title":"IFI16 is an innate immune sensor for intracellular DNA","volume":"11","author":"Unterholzner","year":"2010","journal-title":"Nat. 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