{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T18:25:34Z","timestamp":1793039134113,"version":"4.5.0"},"reference-count":68,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2017,8,1]],"date-time":"2017-08-01T00:00:00Z","timestamp":1501545600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>During RBC transfusion, production of alloantibodies against RBC non-ABO Ags can cause hemolytic transfusion reactions and limit availability of compatible blood products, resulting in anemia-associated morbidity and mortality. Multiple studies have established that certain inflammatory disorders and inflammatory stimuli promote alloimmune responses to RBC Ags. However, the molecular mechanisms underlying these findings are poorly understood. Type I IFNs (IFN-\u03b1\/\u03b2) are induced in inflammatory conditions associated with increased alloimmunization. By developing a new transgenic murine model, we demonstrate that signaling through the IFN-\u03b1\/\u03b2 receptor is required for inflammation-induced alloimmunization. Additionally, mitochondrial antiviral signaling protein\u2013mediated signaling through cytosolic pattern recognition receptors was required for polyinosinic-polycytidylic acid\u2013induced IFN-\u03b1\/\u03b2 production and alloimmunization. We further report that IFN-\u03b1, in the absence of an adjuvant, is sufficient to induce RBC alloimmunization. These findings raise the possibility that patients with IFN-\u03b1\/\u03b2\u2013mediated conditions, including autoimmunity and viral infections, may have an increased risk of RBC alloimmunization and may benefit from personalized transfusion protocols and\/or targeted therapies.<\/jats:p>","DOI":"10.4049\/jimmunol.1700401","type":"journal-article","created":{"date-parts":[[2017,6,20]],"date-time":"2017-06-20T00:10:39Z","timestamp":1497917439000},"page":"1041-1050","source":"Crossref","is-referenced-by-count":62,"title":["Type I IFN Is Necessary and Sufficient for Inflammation-Induced Red Blood Cell Alloimmunization in Mice"],"prefix":"10.1093","volume":"199","author":[{"given":"David R","family":"Gibb","sequence":"first","affiliation":[{"name":"Department of Laboratory Medicine, Yale University School of Medicine , New Haven, CT 06520"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingchun","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Yale University School of Medicine , New Haven, CT 06520"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prabitha","family":"Natarajan","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Yale University School of Medicine , New Haven, CT 06520"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3703-7635","authenticated-orcid":false,"given":"Manjula","family":"Santhanakrishnan","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Yale University School of Medicine , New Haven, CT 06520"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David J","family":"Madrid","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Yale University School of Medicine , New Haven, CT 06520"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1244-208X","authenticated-orcid":false,"given":"Stephanie C","family":"Eisenbarth","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Yale University School of Medicine , New Haven, CT 06520"},{"name":"Department of Immunobiology, Yale University School of Medicine , New Haven, CT 06520"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James C","family":"Zimring","sequence":"additional","affiliation":[{"name":"Bloodworks Northwest Research Institute , Seattle, WA 98102"},{"name":"Department of Laboratory Medicine, University of Washington School of Medicine , Seattle, WA 98195"},{"name":"Division of Hematology, Department of Medicine, University of Washington School of Medicine , Seattle, WA 98195"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7824-9856","authenticated-orcid":false,"given":"Akiko","family":"Iwasaki","sequence":"additional","affiliation":[{"name":"Department of Immunobiology, Yale University School of Medicine , New Haven, CT 06520"},{"name":"Howard Hughes Medical Institute , Chevy Chase, MD 20815"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7928-3132","authenticated-orcid":false,"given":"Jeanne E","family":"Hendrickson","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Yale University School of Medicine , New Haven, CT 06520"},{"name":"Department of Pediatrics, Yale University School of Medicine , New Haven, CT 06520"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2017,8,1]]},"reference":[{"key":"2025030614222470000_r1","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1111\/j.1423-0410.1983.tb01886.x","article-title":"Immune response to chronic red blood cell transfusion","volume":"44","author":"Blumberg","year":"1983","journal-title":"Vox Sang."},{"key":"2025030614222470000_r2","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1046\/j.1537-2995.1990.30690333485.x","article-title":"Incidence of red cell antibodies after multiple blood transfusion","volume":"30","author":"Fluit","year":"1990","journal-title":"Transfusion"},{"key":"2025030614222470000_r3","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1111\/j.1365-2141.1995.tb05425.x","article-title":"A prospective study to determine the frequency and clinical significance of alloimmunization post-transfusion","volume":"91","author":"Heddle","year":"1995","journal-title":"Br. J. Haematol."},{"key":"2025030614222470000_r4","first-page":"42","article-title":"Multiple red cell transfusions and alloimmunization. Experience with 6996 antibodies detected in a total of 159,262 patients from 1985 to 1993","volume":"119","author":"Hoeltge","year":"1995","journal-title":"Arch. Pathol. Lab. Med."},{"key":"2025030614222470000_r5","first-page":"216","article-title":"A prospective study of the incidence of red cell allo-immunisation following transfusion","volume":"71","author":"Redman","year":"1996","journal-title":"Vox Sang."},{"key":"2025030614222470000_r6","doi-asserted-by":"crossref","first-page":"1617","DOI":"10.1056\/NEJM199006073222301","article-title":"Alloimmunization in sickle cell anemia and transfusion of racially unmatched blood","volume":"322","author":"Vichinsky","year":"1990","journal-title":"N. Engl. J. Med."},{"key":"2025030614222470000_r7","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1182\/blood-2011-11-327361","article-title":"Red blood cell alloimmunization in sickle cell disease: pathophysiology, risk factors, and transfusion management","volume":"120","author":"Yazdanbakhsh","year":"2012","journal-title":"Blood"},{"key":"2025030614222470000_r8"},{"key":"2025030614222470000_r9","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1159\/000369179","article-title":"Responder individuality in red blood cell alloimmunization","volume":"41","author":"K\u00f6rm\u00f6czi","year":"2014","journal-title":"Transfus. Med. Hemother."},{"key":"2025030614222470000_r10","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1111\/trf.13379","article-title":"Impact of red blood cell alloimmunization on sickle cell disease mortality: a case series","volume":"56","author":"Nickel","year":"2016","journal-title":"Transfusion"},{"key":"2025030614222470000_r11","doi-asserted-by":"crossref","first-page":"1378","DOI":"10.1111\/trf.12940","article-title":"Alloimmunization in sickle cell disease: changing antibody specificities and association with chronic pain and decreased survival","volume":"55","author":"Telen","year":"2015","journal-title":"Transfusion"},{"key":"2025030614222470000_r12","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1111\/bjh.13123","article-title":"Red blood cell alloimmunization is influenced by recipient inflammatory state at time of transfusion in patients with sickle cell disease","volume":"168","author":"Fasano","year":"2015","journal-title":"Br. J. Haematol."},{"key":"2025030614222470000_r13","doi-asserted-by":"crossref","first-page":"717.e1\u20138","DOI":"10.1016\/j.amjmed.2011.11.028","article-title":"High risk of transfusion-induced alloimmunization of patients with inflammatory bowel disease","volume":"125","author":"Papay","year":"2012","journal-title":"Am J Med."},{"key":"2025030614222470000_r14","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.1111\/j.1537-2995.2009.02116.x","article-title":"Does a febrile reaction to platelets predispose recipients to red blood cell alloimmunization?","volume":"49","author":"Yazer","year":"2009","journal-title":"Transfusion"},{"key":"2025030614222470000_r15","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1046\/j.1537-2995.1995.35795357881.x","article-title":"Multiple or uncommon red cell alloantibodies in women: association with autoimmune disease","volume":"35","author":"Ramsey","year":"1995","journal-title":"Transfusion"},{"key":"2025030614222470000_r16","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1111\/bjh.14307","article-title":"Red cell alloimmunisation in patients with different types of infections","volume":"175","author":"Evers","year":"2016","journal-title":"Br. J. Haematol."},{"key":"2025030614222470000_r17","doi-asserted-by":"crossref","first-page":"e440","DOI":"10.3324\/haematol.2016.149278","article-title":"Interleukin-6 receptor-alpha signaling drives anti-RBC alloantibody production and T-follicular helper cell differentiation in a murine model of red blood cell alloimmunization","volume":"101","author":"Arneja","year":"2016","journal-title":"Haematologica"},{"key":"2025030614222470000_r18","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.ebiom.2016.06.008","article-title":"The Nlrp3 inflammasome does not regulate alloimmunization to transfused red blood cells in mice","volume":"9","author":"Gibb","year":"2016","journal-title":"EBioMedicine"},{"key":"2025030614222470000_r19","doi-asserted-by":"crossref","first-page":"209","DOI":"10.3324\/haematol.2015.134171","article-title":"Red blood cell alloimmunization is influenced by the delay between Toll-like receptor agonist injection and transfusion","volume":"101","author":"Elayeb","year":"2016","journal-title":"Haematologica"},{"key":"2025030614222470000_r20","doi-asserted-by":"crossref","first-page":"1526","DOI":"10.1111\/j.1537-2995.2006.00946.x","article-title":"Recipient inflammation affects the frequency and magnitude of immunization to transfused red blood cells","volume":"46","author":"Hendrickson","year":"2006","journal-title":"Transfusion"},{"key":"2025030614222470000_r21","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1002\/ajh.20959","article-title":"Prevention of red cell alloimmunization by CD25 regulatory T cells in mouse models","volume":"82","author":"Yu","year":"2007","journal-title":"Am. J. Hematol."},{"key":"2025030614222470000_r22","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1159\/000368995","article-title":"Factors influencing RBC alloimmunization: lessons learned from murine models","volume":"41","author":"Ryder","year":"2014","journal-title":"Transfus. Med. Hemother."},{"key":"2025030614222470000_r23","doi-asserted-by":"crossref","first-page":"5624","DOI":"10.1182\/blood-2008-12-193748","article-title":"Regulatory T-cell status in red cell alloimmunized responder and nonresponder mice","volume":"113","author":"Bao","year":"2009","journal-title":"Blood"},{"key":"2025030614222470000_r24","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1111\/trf.12217","article-title":"Transfusion of murine red blood cells expressing the human KEL glycoprotein induces clinically significant alloantibodies","volume":"54","author":"Stowell","year":"2014","journal-title":"Transfusion"},{"key":"2025030614222470000_r25","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1111\/j.1537-2995.2009.02481.x","article-title":"Storage of murine red blood cells enhances alloantibody responses to an erythroid-specific model antigen","volume":"50","author":"Hendrickson","year":"2010","journal-title":"Transfusion"},{"key":"2025030614222470000_r26","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1038\/ni1087","article-title":"The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses","volume":"5","author":"Yoneyama","year":"2004","journal-title":"Nat. Immunol."},{"key":"2025030614222470000_r27","doi-asserted-by":"crossref","first-page":"8459","DOI":"10.1073\/pnas.0603082103","article-title":"Essential role of mda-5 in type I IFN responses to polyriboinosinic:polyribocytidylic acid and encephalomyocarditis picornavirus","volume":"103","author":"Gitlin","year":"2006","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2025030614222470000_r28","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1038\/35099560","article-title":"Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3","volume":"413","author":"Alexopoulou","year":"2001","journal-title":"Nature"},{"key":"2025030614222470000_r29","doi-asserted-by":"crossref","first-page":"5119","DOI":"10.1016\/j.vaccine.2006.04.010","article-title":"The adjuvant effects of the toll-like receptor 3 ligand polyinosinic-cytidylic acid poly (I:C) on antigen-specific CD8+ T cell responses are partially dependent on NK cells with the induction of a beneficial cytokine milieu","volume":"24","author":"Salem","year":"2006","journal-title":"Vaccine"},{"key":"2025030614222470000_r30","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1016\/j.molcel.2006.05.012","article-title":"Toll-like receptors and RNA helicases: two parallel ways to trigger antiviral responses","volume":"22","author":"Meylan","year":"2006","journal-title":"Mol. Cell"},{"key":"2025030614222470000_r31","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1038\/nri3787","article-title":"Type I interferons in infectious disease","volume":"15","author":"McNab","year":"2015","journal-title":"Nat. Rev. Immunol."},{"key":"2025030614222470000_r32","doi-asserted-by":"crossref","first-page":"375","DOI":"10.4049\/jimmunol.169.1.375","article-title":"Type I IFN as a natural adjuvant for a protective immune response: lessons from the influenza vaccine model","volume":"169","author":"Proietti","year":"2002","journal-title":"J. Immunol."},{"key":"2025030614222470000_r33","doi-asserted-by":"crossref","first-page":"2074","DOI":"10.4049\/jimmunol.176.4.2074","article-title":"Cutting edge: enhancement of antibody responses through direct stimulation of B and T cells by type I IFN","volume":"176","author":"Le Bon","year":"2006","journal-title":"J. Immunol."},{"key":"2025030614222470000_r34","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1136\/ard.2003.017194","article-title":"A gene expression signature for recent onset rheumatoid arthritis in peripheral blood mononuclear cells","volume":"63","author":"Olsen","year":"2004","journal-title":"Ann. Rheum. Dis."},{"key":"2025030614222470000_r35","doi-asserted-by":"crossref","first-page":"2029","DOI":"10.1136\/ard.2011.150326","article-title":"Patients with systemic lupus erythematosus, myositis, rheumatoid arthritis and scleroderma share activation of a common type I interferon pathway","volume":"70","author":"Higgs","year":"2011","journal-title":"Ann. Rheum. Dis."},{"key":"2025030614222470000_r36","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1002\/art.20998","article-title":"Activation of the type I interferon system in primary Sj\u00f6gren\u2019s syndrome: a possible etiopathogenic mechanism","volume":"52","author":"B\u00e5ve","year":"2005","journal-title":"Arthritis Rheum."},{"key":"2025030614222470000_r37","doi-asserted-by":"crossref","first-page":"59","DOI":"10.2119\/2006-00085.Baechler","article-title":"An interferon signature in the peripheral blood of dermatomyositis patients is associated with disease activity","volume":"13","author":"Baechler","year":"2007","journal-title":"Mol. Med."},{"key":"2025030614222470000_r38","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1002\/art.27224","article-title":"Systemic sclerosis and lupus: points in an interferon-mediated continuum","volume":"62","author":"Assassi","year":"2010","journal-title":"Arthritis Rheum."},{"key":"2025030614222470000_r39","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1002\/art.1780250407","article-title":"Serum interferon levels in patients with systemic lupus erythematosus","volume":"25","author":"Ytterberg","year":"1982","journal-title":"Arthritis Rheum."},{"key":"2025030614222470000_r40","doi-asserted-by":"crossref","first-page":"2951","DOI":"10.1002\/art.22044","article-title":"Association of increased interferon-inducible gene expression with disease activity and lupus nephritis in patients with systemic lupus erythematosus","volume":"54","author":"Feng","year":"2006","journal-title":"Arthritis Rheum."},{"key":"2025030614222470000_r41","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1080\/08916930310001625952","article-title":"Microarray analysis of interferon-regulated genes in SLE","volume":"36","author":"Crow","year":"2003","journal-title":"Autoimmunity"},{"key":"2025030614222470000_r42","doi-asserted-by":"crossref","first-page":"2610","DOI":"10.1073\/pnas.0337679100","article-title":"Interferon-inducible gene expression signature in peripheral blood cells of patients with severe lupus","volume":"100","author":"Baechler","year":"2003","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2025030614222470000_r43","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1016\/j.coi.2012.07.008","article-title":"The genetics of type I interferon in systemic lupus erythematosus","volume":"24","author":"Bronson","year":"2012","journal-title":"Curr. Opin. Immunol."},{"key":"2025030614222470000_r44","doi-asserted-by":"crossref","first-page":"1785","DOI":"10.1002\/art.24557","article-title":"Neutralization of interferon-alpha\/beta-inducible genes and downstream effect in a phase I trial of an anti-interferon-alpha monoclonal antibody in systemic lupus erythematosus","volume":"60","author":"Yao","year":"2009","journal-title":"Arthritis Rheum."},{"key":"2025030614222470000_r45","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1002\/art.37824","article-title":"Sifalimumab, a human anti-interferon-\u03b1 monoclonal antibody, in systemic lupus erythematosus: a phase I randomized, controlled, dose-escalation study","volume":"65","author":"Petri","year":"2013","journal-title":"Arthritis Rheum."},{"key":"2025030614222470000_r46","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1111\/bjh.14175","article-title":"Estimating the immunogenicity of blood group antigens: a modified calculation that corrects for transfusion exposures","volume":"175","author":"Stack","year":"2016","journal-title":"Br. J. Haematol."},{"key":"2025030614222470000_r47","doi-asserted-by":"crossref","first-page":"1328","DOI":"10.1111\/j.1537-2995.2006.00900.x","article-title":"Relative immunogenicity of Fya and K antigens in a Caucasian population, based on HLA class II restriction analysis","volume":"46","author":"Noizat-Pirenne","year":"2006","journal-title":"Transfusion"},{"key":"2025030614222470000_r48","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1046\/j.1537-2995.1990.30290162904.x","article-title":"The kell blood group system: a review","volume":"30","author":"Marsh","year":"1990","journal-title":"Transfusion"},{"key":"2025030614222470000_r49","doi-asserted-by":"crossref","first-page":"1918","DOI":"10.1126\/science.8009221","article-title":"Functional role of type I and type II interferons in antiviral defense","volume":"264","author":"M\u00fcller","year":"1994","journal-title":"Science"},{"key":"2025030614222470000_r50","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1016\/j.immuni.2006.04.004","article-title":"The specific and essential role of MAVS in antiviral innate immune responses","volume":"24","author":"Sun","year":"2006","journal-title":"Immunity"},{"key":"2025030614222470000_r51","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1016\/S1074-7613(00)00053-4","article-title":"Distinct and essential roles of transcription factors IRF-3 and IRF-7 in response to viruses for IFN-alpha\/beta gene induction","volume":"13","author":"Sato","year":"2000","journal-title":"Immunity"},{"key":"2025030614222470000_r52","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1038\/nature03464","article-title":"IRF-7 is the master regulator of type-I interferon-dependent immune responses","volume":"434","author":"Honda","year":"2005","journal-title":"Nature"},{"key":"2025030614222470000_r53","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1126\/science.1087262","article-title":"Role of adaptor TRIF in the MyD88-independent toll-like receptor signaling pathway","volume":"301","author":"Yamamoto","year":"2003","journal-title":"Science"},{"key":"2025030614222470000_r54","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/S1074-7613(00)80596-8","article-title":"Targeted disruption of the MyD88 gene results in loss of IL-1- and IL-18-mediated function","volume":"9","author":"Adachi","year":"1998","journal-title":"Immunity"},{"key":"2025030614222470000_r55","doi-asserted-by":"crossref","first-page":"2620","DOI":"10.1111\/j.1537-2995.2012.03641.x","article-title":"Generation of transgenic mice with antithetical KEL1 and KEL2 human blood group antigens on red blood cells","volume":"52","author":"Smith","year":"2012","journal-title":"Transfusion"},{"key":"2025030614222470000_r56","doi-asserted-by":"crossref","first-page":"2315","DOI":"10.1182\/blood-2009-04-214387","article-title":"Minor histocompatibility antigens on transfused leukoreduced units of red blood cells induce bone marrow transplant rejection in a mouse model","volume":"114","author":"Desmarets","year":"2009","journal-title":"Blood"},{"key":"2025030614222470000_r57","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/gene.20020","article-title":"Transgenic Cre expression mice for generation of erythroid-specific gene alterations","volume":"39","author":"Peterson","year":"2004","journal-title":"Genesis"},{"key":"2025030614222470000_r58","doi-asserted-by":"crossref","first-page":"1494","DOI":"10.1182\/blood-2013-03-488874","article-title":"Alloantibodies to a paternally derived RBC KEL antigen lead to hemolytic disease of the fetus\/newborn in a murine model","volume":"122","author":"Stowell","year":"2013","journal-title":"Blood"},{"key":"2025030614222470000_r59","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1084\/jem.20030162","article-title":"Toll-like receptor 9-mediated recognition of Herpes simplex virus-2 by plasmacytoid dendritic cells","volume":"198","author":"Lund","year":"2003","journal-title":"J. Exp. Med."},{"key":"2025030614222470000_r60","doi-asserted-by":"crossref","first-page":"1589","DOI":"10.1084\/jem.20090247","article-title":"Dendritic cells require a systemic type I interferon response to mature and induce CD4+ Th1 immunity with poly IC as adjuvant","volume":"206","author":"Longhi","year":"2009","journal-title":"J. Exp. Med."},{"key":"2025030614222470000_r61","doi-asserted-by":"crossref","first-page":"3263","DOI":"10.1182\/blood.V99.9.3263","article-title":"Type I interferons produced by dendritic cells promote their phenotypic and functional activation","volume":"99","author":"Montoya","year":"2002","journal-title":"Blood"},{"key":"2025030614222470000_r62","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1016\/j.immuni.2013.06.019","article-title":"Monocyte-derived dendritic cells perform hemophagocytosis to fine-tune excessive immune responses","volume":"39","author":"Ohyagi","year":"2013","journal-title":"Immunity"},{"key":"2025030614222470000_r63","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1084\/jem.20151720","article-title":"Bridging channel dendritic cells induce immunity to transfused red blood cells","volume":"213","author":"Calabro","year":"2016","journal-title":"J. Exp. Med."},{"key":"2025030614222470000_r64","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1111\/j.1537-2995.2011.03346.x","article-title":"Alloimmunization to transfused platelets requires priming of CD4+ T cells in the splenic microenvironment in a murine model","volume":"52","author":"Gilson","year":"2012","journal-title":"Transfusion"},{"key":"2025030614222470000_r65","doi-asserted-by":"crossref","first-page":"20416","DOI":"10.1073\/pnas.0808537105","article-title":"Visualization of IFNbeta production by plasmacytoid versus conventional dendritic cells under specific stimulation conditions in vivo","volume":"105","author":"Scheu","year":"2008","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2025030614222470000_r66","doi-asserted-by":"crossref","first-page":"e1003323","DOI":"10.1371\/journal.pcbi.1003323","article-title":"Linking transcriptional changes over time in stimulated dendritic cells to identify gene networks activated during the innate immune response","volume":"9","author":"Patil","year":"2013","journal-title":"PLoS Comput. Biol."},{"key":"2025030614222470000_r67","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1002\/eji.200323797","article-title":"Toll-like receptor expression in murine DC subsets: lack of TLR7 expression by CD8 alpha+ DC correlates with unresponsiveness to imidazoquinolines","volume":"33","author":"Edwards","year":"2003","journal-title":"Eur. J. Immunol."},{"key":"2025030614222470000_r68","doi-asserted-by":"crossref","first-page":"1566","DOI":"10.1182\/blood-2011-09-382655","article-title":"Transfusion in the absence of inflammation induces antigen-specific tolerance to murine RBCs","volume":"119","author":"Smith","year":"2012","journal-title":"Blood"}],"container-title":["The Journal of Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/199\/3\/1041\/61521522\/ji1700401.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/199\/3\/1041\/61521522\/ji1700401.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,6]],"date-time":"2025-03-06T16:17:27Z","timestamp":1741277847000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jimmunol\/article\/199\/3\/1041\/7964818"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8,1]]},"references-count":68,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2017,8,1]]}},"URL":"https:\/\/doi.org\/10.4049\/jimmunol.1700401","relation":{},"ISSN":["0022-1767","1550-6606"],"issn-type":[{"value":"0022-1767","type":"print"},{"value":"1550-6606","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2017,8]]},"published":{"date-parts":[[2017,8,1]]}}}