{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T20:37:30Z","timestamp":1779395850324,"version":"3.53.1"},"reference-count":44,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2018,12,1]],"date-time":"2018-12-01T00:00:00Z","timestamp":1543622400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Vaccination has been the most effective way to prevent or reduce infectious diseases; examples include the eradication of smallpox and attenuation of tetanus and measles. However, there is a large segment of the population that responds poorly to vaccines, in part because they are immunocompromised because of disease, age, or pharmacologic therapy and are unable to generate long-term protection. Specialized proresolving mediators are endogenously produced lipids that have potent proresolving and anti-inflammatory activities. Lipoxin B4 (LXB4) is a member of the lipoxin family, with its proresolving effects shown in allergic airway inflammation. However, its effects on the adaptive immune system, especially on human B cells, are not known. In this study, we investigated the effects of LXB4 on human B cells using cells from healthy donors and donors vaccinated against influenza virus in vitro. LXB4 promoted IgG Ab production in memory B cells and also increased the number of IgG-secreting B cells. LXB4 enhanced expression of two key transcription factors involved in plasma cell differentiation, BLIMP1 and XBP1. Interestingly, LXB4 increased expression of cyclooxygenase-2 (COX2), an enzyme that is required for efficient B cell Ab production. The effects of LXB4 are at least partially COX2-dependent as COX2 inhibitors attenuated LXB4-stimulated BLIMP1 and Xpb-1 expression as well as IgG production. Thus, our study reveals for the first time, to our knowledge, that LXB4 boosts memory B cell activation through COX2 and suggests that LXB4 can serve as a new vaccine adjuvant.<\/jats:p>","DOI":"10.4049\/jimmunol.1700503","type":"journal-article","created":{"date-parts":[[2018,10,22]],"date-time":"2018-10-22T14:32:43Z","timestamp":1540218763000},"page":"3343-3351","source":"Crossref","is-referenced-by-count":38,"title":["Lipoxin B4 Enhances Human Memory B Cell Antibody Production via Upregulating Cyclooxygenase-2 Expression"],"prefix":"10.1093","volume":"201","author":[{"given":"Nina","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Microbiology and Immunology, University of Rochester , Rochester, NY 14642"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katie L","family":"Lannan","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, University of Rochester , Rochester, NY 14642"},{"name":"Department of Environmental Medicine, University of Rochester , Rochester, NY 14642"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7177-3041","authenticated-orcid":false,"given":"Thomas H","family":"Thatcher","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Critical Care Medicine, University of Rochester , Rochester, NY 14642"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2091-1675","authenticated-orcid":false,"given":"Stephen J","family":"Pollock","sequence":"additional","affiliation":[{"name":"Department of Environmental Medicine, University of Rochester , Rochester, NY 14642"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Collynn F","family":"Woeller","sequence":"additional","affiliation":[{"name":"Department of Environmental Medicine, University of Rochester , Rochester, NY 14642"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6428-1388","authenticated-orcid":false,"given":"Richard P","family":"Phipps","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, University of Rochester , Rochester, NY 14642"},{"name":"Department of Environmental Medicine, University of Rochester , Rochester, NY 14642"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2018,12,1]]},"reference":[{"key":"2025030417575136800_r1","doi-asserted-by":"crossref","first-page":"50","DOI":"10.7774\/cevr.2014.3.1.50","article-title":"Vaccine allergies","volume":"3","author":"Chung","year":"2014","journal-title":"Clin. 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