{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T04:47:50Z","timestamp":1791002870389,"version":"4.1.0"},"reference-count":34,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2017,12,1]],"date-time":"2017-12-01T00:00:00Z","timestamp":1512086400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,12,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Sj\u00f6gren\u2019s syndrome (SS) is an autoimmune disease in which exocrine tissues are affected by cellular and humoral immunity. As a result, the salivary and lacrimal glands of patients with SS are damaged, leading to xerostomia (dry mouth) and keratoconjunctivitis sicca (dry eyes). Because experimental approaches to investigate SS pathogenesis in human patients are limited, development of a mouse model is indispensable for understanding the disease. In this study, we show that special AT-rich sequence binding protein-1 conditional knockout (SATB1cKO) mice, in which the SATB1 gene is specifically deleted from hematopoietic cells, develop SS by 4 wk of age, soon after weaning. Female mice presented an earlier onset of the disease than males, suggesting that female SATB1cKO mice are more susceptible to SS. T cell\u2013dominant immune cell infiltration was observed in the salivary glands of 4 wk old SATB1cKO mice, and the frequency of B cells gradually increased as the mice aged. Consistently, levels of anti-SSA and anti-SSB Abs were increased around 8 wk of age, after salivary production reached its lowest level in SATB1cKO mice. These results suggest that SATB1cKO mice can be a novel SS model, in which the progression and characteristics of the disease resemble those of human SS.<\/jats:p>","DOI":"10.4049\/jimmunol.1700550","type":"journal-article","created":{"date-parts":[[2017,11,10]],"date-time":"2017-11-10T17:10:15Z","timestamp":1510333815000},"page":"4016-4022","source":"Crossref","is-referenced-by-count":23,"title":["SATB1 Conditional Knockout Results in Sj\u00f6gren\u2019s Syndrome in Mice"],"prefix":"10.1093","volume":"199","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9278-7677","authenticated-orcid":false,"given":"Yuriko","family":"Tanaka","sequence":"first","affiliation":[{"name":"Department of Molecular Immunology, Toho University School of Medicine , Tokyo 143-8540,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takehiko","family":"Sotome","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Toho University Omori Medical Center , Tokyo 143-8541,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akiko","family":"Inoue","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Toho University Omori Medical Center , Tokyo 143-8541,","place":["Japan"]},{"name":"Toho University Graduate School of Medicine , Tokyo 143-8540,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takanori","family":"Mukozu","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Department of Internal Medicine, Toho University Omori Medical Center , Tokyo 143-8541,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5985-8245","authenticated-orcid":false,"given":"Taku","family":"Kuwabara","sequence":"additional","affiliation":[{"name":"Department of Molecular Immunology, Toho University School of Medicine , Tokyo 143-8540,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetuo","family":"Mikami","sequence":"additional","affiliation":[{"name":"Department of Pathology, Toho University School of Medicine , Tokyo 143-8540,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Terumi","family":"Kowhi-Shigematsu","sequence":"additional","affiliation":[{"name":"Department of Orofacial Sciences, University of California San Francisco School of Dentistry , San Francisco, CA 94143"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1565-8804","authenticated-orcid":false,"given":"Motonari","family":"Kondo","sequence":"additional","affiliation":[{"name":"Department of Molecular Immunology, Toho University School of Medicine , Tokyo 143-8540,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2017,12,15]]},"reference":[{"key":"2025030614543422200_r1","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1038\/nm.3897","article-title":"Heterogeneity of autoimmune diseases: pathophysiologic insights from genetics and implications for new therapies","volume":"21","author":"Cho","year":"2015","journal-title":"Nat. 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