{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T15:00:18Z","timestamp":1790434818763,"version":"4.1.0"},"reference-count":41,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2017,10,1]],"date-time":"2017-10-01T00:00:00Z","timestamp":1506816000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,10,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The neurobeachin-like 2 protein (Nbeal2) belongs to the family of beige and Chediak\u2013Higashi (BEACH) domain proteins. Loss-of-function mutations in the human NBEAL2 gene or Nbeal2 deficiency in mice cause gray platelet syndrome, a bleeding disorder characterized by macrothrombocytopenia, splenomegaly, and paucity of \u03b1-granules in megakaryocytes and platelets. We found that in mast cells, Nbeal2 regulates the activation of the Shp1-STAT5 signaling axis and the composition of the c-Kit\/STAT signalosome. Furthermore, Nbeal2 mediates granule formation and restricts the expression of the transcription factors, IRF8, GATA2, and MITF as well as of the cell-cycle inhibitor p27, which are essential for mast cell differentiation, proliferation, and cytokine production. These data demonstrate the relevance of Nbeal2 in mast cells above and beyond granule biosynthesis.<\/jats:p>","DOI":"10.4049\/jimmunol.1700556","type":"journal-article","created":{"date-parts":[[2017,9,9]],"date-time":"2017-09-09T00:30:37Z","timestamp":1504917037000},"page":"2948-2957","source":"Crossref","is-referenced-by-count":22,"title":["The Neurobeachin-like 2 Protein Regulates Mast Cell Homeostasis"],"prefix":"10.1093","volume":"199","author":[{"given":"Sebastian","family":"Drube","sequence":"first","affiliation":[{"name":"Institute of Immunology, Jena University Hospital , 07743 Jena,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Randy","family":"Grimlowski","sequence":"additional","affiliation":[{"name":"Institute of Immunology, Jena University Hospital , 07743 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