{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T21:42:13Z","timestamp":1790199733635,"version":"4.1.0"},"reference-count":55,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2017,12,1]],"date-time":"2017-12-01T00:00:00Z","timestamp":1512086400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,12,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Acute liver injury can be secondary to a variety of causes, including infections, intoxication, and ischemia. All of these insults induce hepatocyte death and subsequent inflammation, which can make acute liver injury a life-threatening event. IL-22 is a dual natured cytokine which has context-dependent protective and pathogenic properties during tissue damage. Accordingly, IL-22 was shown to promote liver regeneration upon acute liver damage. However, other studies suggest pathogenic properties of IL-22 during chronic liver injury. IL-22 binding protein (IL-22BP, IL-22Ra2) is a soluble inhibitor of IL-22 that regulates IL-22 activity. However, the significance of endogenous IL-22BP in acute liver injury is unknown. We hypothesized that IL-22BP may play a role in acute liver injury. To test this hypothesis, we used Il22bp-deficient mice and murine models of acute liver damage induced by ischemia reperfusion and N-acetyl-p-aminophenol (acetaminophen) administration. We found that Il22bp-deficient mice were more susceptible to acute liver damage in both models. We used Il22 \u00d7 Il22bp double-deficient mice to show that this effect is indeed due to uncontrolled IL-22 activity. We could demonstrate mechanistically increased expression of Cxcl10 by hepatocytes, and consequently increased infiltration of inflammatory CD11b+Ly6C+ monocytes into the liver in Il22bp-deficient mice upon liver damage. Accordingly, neutralization of CXCL10 reversed the increased disease susceptibility of Il22bp-deficient mice. In conclusion, our data indicate that IL-22BP plays a protective role in acute liver damage, via controlling IL-22\u2013induced Cxcl10 expression.<\/jats:p>","DOI":"10.4049\/jimmunol.1700587","type":"journal-article","created":{"date-parts":[[2017,11,6]],"date-time":"2017-11-06T15:50:11Z","timestamp":1509983411000},"page":"4078-4090","source":"Crossref","is-referenced-by-count":44,"title":["A Protective Function of IL-22BP in Ischemia Reperfusion and Acetaminophen-Induced Liver Injury"],"prefix":"10.1093","volume":"199","author":[{"given":"D\u00f6rte","family":"Kleinschmidt","sequence":"first","affiliation":[{"name":"I. Department of Medicine, University Medical Center Hamburg-Eppendorf , 20246 Hamburg,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anastasios D","family":"Giannou","sequence":"additional","affiliation":[{"name":"I. Department of Medicine, University Medical Center Hamburg-Eppendorf , 20246 Hamburg,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heather M","family":"McGee","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Icahn School of Medicine at Mount Sinai , New York, NY 10029"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8867-5077","authenticated-orcid":false,"given":"Jan","family":"Kempski","sequence":"additional","affiliation":[{"name":"I. Department of Medicine, University Medical Center Hamburg-Eppendorf , 20246 Hamburg,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Babett","family":"Steglich","sequence":"additional","affiliation":[{"name":"I. Department of Medicine, University Medical Center Hamburg-Eppendorf , 20246 Hamburg,","place":["Germany"]},{"name":"Department of General, Visceral and Thoracic Surgery, University Medical Center Hamburg-Eppendorf , 20246 Hamburg,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francis Jessica","family":"Huber","sequence":"additional","affiliation":[{"name":"I. Department of Medicine, University Medical Center Hamburg-Eppendorf , 20246 Hamburg,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2170-9241","authenticated-orcid":false,"given":"Thomas Michael","family":"Ernst","sequence":"additional","affiliation":[{"name":"Department and Clinic for Diagnostic and Interventional Radiology and Nuclear Medicine, University Medical Center Hamburg-Eppendorf , 20246 Hamburg,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmad Mustafa","family":"Shiri","sequence":"additional","affiliation":[{"name":"I. Department of Medicine, University Medical Center Hamburg-Eppendorf , 20246 Hamburg,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9905-6386","authenticated-orcid":false,"given":"Claudia","family":"Wegscheid","sequence":"additional","affiliation":[{"name":"Institute of Experimental Immunology and Hepatology, University Medical Center Hamburg-Eppendorf , 20246 Hamburg,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Tasika","sequence":"additional","affiliation":[{"name":"Institute of Experimental Immunology and Hepatology, University Medical Center Hamburg-Eppendorf , 20246 Hamburg,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"H\u00fcbener","sequence":"additional","affiliation":[{"name":"I. Department of Medicine, University Medical Center Hamburg-Eppendorf , 20246 Hamburg,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3244-2300","authenticated-orcid":false,"given":"Philipp","family":"Huber","sequence":"additional","affiliation":[{"name":"I. Department of Medicine, University Medical Center Hamburg-Eppendorf , 20246 Hamburg,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanja","family":"Bedke","sequence":"additional","affiliation":[{"name":"I. Department of Medicine, University Medical Center Hamburg-Eppendorf , 20246 Hamburg,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niklas","family":"Steffens","sequence":"additional","affiliation":[{"name":"I. Department of Medicine, University Medical Center Hamburg-Eppendorf , 20246 Hamburg,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theodora","family":"Agalioti","sequence":"additional","affiliation":[{"name":"Department of General, Visceral and Thoracic Surgery, University Medical Center Hamburg-Eppendorf , 20246 Hamburg,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tobias","family":"Fuchs","sequence":"additional","affiliation":[{"name":"Institute of Clinical Chemistry and Central Laboratories, University Medical Center Hamburg-Eppendorf , 20246 Hamburg,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8635-3445","authenticated-orcid":false,"given":"Jill","family":"Noll","sequence":"additional","affiliation":[{"name":"Bernhard Nocht Institute for Tropical Medicine , 20359 Hamburg,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannelore","family":"Lotter","sequence":"additional","affiliation":[{"name":"Bernhard Nocht Institute for Tropical Medicine , 20359 Hamburg,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gisa","family":"Tiegs","sequence":"additional","affiliation":[{"name":"Institute of Experimental Immunology and Hepatology, University Medical Center Hamburg-Eppendorf , 20246 Hamburg,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ansgar W","family":"Lohse","sequence":"additional","affiliation":[{"name":"I. Department of Medicine, University Medical Center Hamburg-Eppendorf , 20246 Hamburg,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan H","family":"Axelrod","sequence":"additional","affiliation":[{"name":"Goldyne Savad Institute of Gene Therapy, Hadassah Hebrew University Hospital , Jerusalem 91120,","place":["Israel"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eithan","family":"Galun","sequence":"additional","affiliation":[{"name":"Goldyne Savad Institute of Gene Therapy, Hadassah Hebrew University Hospital , Jerusalem 91120,","place":["Israel"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4461-0778","authenticated-orcid":false,"given":"Richard A","family":"Flavell","sequence":"additional","affiliation":[{"name":"Department of Immunobiology, School of Medicine, Yale University , New Haven, CT 06520"},{"name":"Howard Hughes Medical Institute, Yale University School of Medicine , New Haven, CT 06520"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola","family":"Gagliani","sequence":"additional","affiliation":[{"name":"I. Department of Medicine, University Medical Center Hamburg-Eppendorf , 20246 Hamburg,","place":["Germany"]},{"name":"Department of General, Visceral and Thoracic Surgery, University Medical Center Hamburg-Eppendorf , 20246 Hamburg,","place":["Germany"]},{"name":"Immunology and Allergy Unit, Department of Medicine Solna, Karolinska Institute , 17176 Stockholm,","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel","family":"Huber","sequence":"additional","affiliation":[{"name":"I. Department of Medicine, University Medical Center Hamburg-Eppendorf , 20246 Hamburg,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2017,12,15]]},"reference":[{"key":"2025030614550168900_r1","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1016\/j.jhep.2008.08.009","article-title":"The importance of immune dysfunction in determining outcome in acute liver failure","volume":"49","author":"Antoniades","year":"2008","journal-title":"J. Hepatol."},{"key":"2025030614550168900_r2","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/j.cytogfr.2010.08.002","article-title":"Interleukin-22: a cytokine produced by T, NK and NKT cell subsets, with importance in the innate immune defense and tissue protection","volume":"21","author":"Witte","year":"2010","journal-title":"Cytokine Growth Factor Rev."},{"key":"2025030614550168900_r3","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1038\/ni.3332","article-title":"Complementarity and redundancy of IL-22-producing innate lymphoid cells","volume":"17","author":"Rankin","year":"2016","journal-title":"Nat. Immunol."},{"key":"2025030614550168900_r4","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1038\/jid.2012.463","article-title":"IL-22 promotes fibroblast-mediated wound repair in the skin","volume":"133","author":"McGee","year":"2013","journal-title":"J. Invest. Dermatol."},{"key":"2025030614550168900_r5","doi-asserted-by":"crossref","first-page":"33676","DOI":"10.1074\/jbc.M204204200","article-title":"Interleukin-22 (IL-22) activates the JAK\/STAT, ERK, JNK, and p38 MAP kinase pathways in a rat hepatoma cell line. Pathways that are shared with and distinct from IL-10","volume":"277","author":"Lejeune","year":"2002","journal-title":"J. Biol. Chem."},{"key":"2025030614550168900_r6","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1038\/ni.2025","article-title":"Border patrol: regulation of immunity, inflammation and tissue homeostasis at barrier surfaces by IL-22","volume":"12","author":"Sonnenberg","year":"2011","journal-title":"Nat. Immunol."},{"key":"2025030614550168900_r7","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1007\/s00109-016-1391-6","article-title":"Biological and pathological activities of interleukin-22","volume":"94","author":"Perusina Lanfranca","year":"2016","journal-title":"J. Mol. Med. (Berl.)"},{"key":"2025030614550168900_r8","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1084\/jem.20102149","article-title":"Memory\/effector (CD45RB(lo)) CD4 T cells are controlled directly by IL-10 and cause IL-22-dependent intestinal pathology","volume":"208","author":"Kamanaka","year":"2011","journal-title":"J. Exp. Med."},{"key":"2025030614550168900_r9","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1007\/s10875-011-9540-8","article-title":"Elevated Th22 cells correlated with Th17 cells in patients with rheumatoid arthritis","volume":"31","author":"Zhang","year":"2011","journal-title":"J. Clin. Immunol."},{"key":"2025030614550168900_r10","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1007\/s00109-009-0457-0","article-title":"IL-22 and IL-20 are key mediators of the epidermal alterations in psoriasis while IL-17 and IFN-gamma are not","volume":"87","author":"Wolk","year":"2009","journal-title":"J. Mol. Med. (Berl.)"},{"key":"2025030614550168900_r11","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1002\/hep.24339","article-title":"In vivo consequences of liver-specific interleukin-22 expression in mice: Implications for human liver disease progression","volume":"54","author":"Park","year":"2011","journal-title":"Hepatology"},{"key":"2025030614550168900_r12","doi-asserted-by":"crossref","first-page":"1332","DOI":"10.1002\/hep.20184","article-title":"Interleukin 22 (IL-22) plays a protective role in T cell-mediated murine hepatitis: IL-22 is a survival factor for hepatocytes via STAT3 activation","volume":"39","author":"Radaeva","year":"2004","journal-title":"Hepatology"},{"key":"2025030614550168900_r13","doi-asserted-by":"crossref","first-page":"10144","DOI":"10.1073\/pnas.170291697","article-title":"Human interleukin-10-related T cell-derived inducible factor: molecular cloning and functional characterization as an hepatocyte-stimulating factor","volume":"97","author":"Dumoutier","year":"2000","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2025030614550168900_r14","doi-asserted-by":"crossref","first-page":"5531","DOI":"10.4049\/jimmunol.0904091","article-title":"IL-22 induces an acute-phase response","volume":"185","author":"Liang","year":"2010","journal-title":"J. Immunol."},{"key":"2025030614550168900_r15","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1002\/hep.23837","article-title":"Interleukin-22 treatment ameliorates alcoholic liver injury in a murine model of chronic-binge ethanol feeding: role of signal transducer and activator of transcription 3","volume":"52","author":"Ki","year":"2010","journal-title":"Hepatology"},{"key":"2025030614550168900_r16","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1016\/j.immuni.2007.07.023","article-title":"Interleukin-22 but not interleukin-17 provides protection to hepatocytes during acute liver inflammation","volume":"27","author":"Zenewicz","year":"2007","journal-title":"Immunity"},{"key":"2025030614550168900_r17","first-page":"43","article-title":"Hydrodynamic gene delivery of interleukin-22 protects the mouse liver from concanavalin A-, carbon tetrachloride-, and Fas ligand-induced injury via activation of STAT3","volume":"1","author":"Pan","year":"2004","journal-title":"Cell. Mol. Immunol."},{"key":"2025030614550168900_r18","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.clim.2015.03.003","article-title":"Up-regulation of interleukin-22 mediates liver fibrosis via activating hepatic stellate cells in patients with hepatitis C","volume":"158","author":"Wu","year":"2015","journal-title":"Clin. Immunol."},{"key":"2025030614550168900_r19","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1186\/1741-7015-10-102","article-title":"Interleukin-22 predicts severity and death in advanced liver cirrhosis: a prospective cohort study","volume":"10","author":"Kronenberger","year":"2012","journal-title":"BMC Med."},{"key":"2025030614550168900_r20","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1002\/hep.26916","article-title":"Pathological functions of interleukin-22 in chronic liver inflammation and fibrosis with hepatitis B virus infection by promoting T helper 17 cell recruitment","volume":"59","author":"Zhao","year":"2014","journal-title":"Hepatology"},{"key":"2025030614550168900_r21","doi-asserted-by":"crossref","first-page":"1897","DOI":"10.1053\/j.gastro.2011.06.051","article-title":"A proinflammatory role for interleukin-22 in the immune response to hepatitis B virus","volume":"141","author":"Zhang","year":"2011","journal-title":"Gastroenterology"},{"key":"2025030614550168900_r22","doi-asserted-by":"crossref","first-page":"7090","DOI":"10.4049\/jimmunol.166.12.7090","article-title":"Cloning and characterization of IL-22 binding protein, a natural antagonist of IL-10-related T cell-derived inducible factor\/IL-22","volume":"166","author":"Dumoutier","year":"2001","journal-title":"J. Immunol."},{"key":"2025030614550168900_r23","doi-asserted-by":"crossref","first-page":"7096","DOI":"10.4049\/jimmunol.166.12.7096","article-title":"Identification, cloning, and characterization of a novel soluble receptor that binds IL-22 and neutralizes its activity","volume":"166","author":"Kotenko","year":"2001","journal-title":"J. Immunol."},{"key":"2025030614550168900_r24","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1038\/sj.gene.6363947","article-title":"Cloning and characterization of mouse IL-22 binding protein","volume":"4","author":"Wei","year":"2003","journal-title":"Genes Immun."},{"key":"2025030614550168900_r25","doi-asserted-by":"crossref","first-page":"1690","DOI":"10.1128\/IAI.01564-06","article-title":"Inhibition of interleukin-22 attenuates bacterial load and organ failure during acute polymicrobial sepsis","volume":"75","author":"Weber","year":"2007","journal-title":"Infect. Immun."},{"key":"2025030614550168900_r26","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1038\/nature11535","article-title":"IL-22BP is regulated by the inflammasome and modulates tumorigenesis in the intestine","volume":"491","author":"Huber","year":"2012","journal-title":"Nature"},{"key":"2025030614550168900_r27","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1126\/science.aah5903","article-title":"A pathogenic role for T cell-derived IL-22BP in inflammatory bowel disease","volume":"354","author":"Pelczar","year":"2016","journal-title":"Science"},{"key":"2025030614550168900_r28","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1016\/j.str.2008.06.005","article-title":"Structure of IL-22 bound to its high-affinity IL-22R1 chain","volume":"16","author":"Jones","year":"2008","journal-title":"Structure"},{"key":"2025030614550168900_r29","doi-asserted-by":"crossref","first-page":"5973","DOI":"10.4049\/jimmunol.178.9.5973","article-title":"IL-22 induces lipopolysaccharide-binding protein in hepatocytes: a potential systemic role of IL-22 in Crohn\u2019s disease","volume":"178","author":"Wolk","year":"2007","journal-title":"J. Immunol."},{"key":"2025030614550168900_r30","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1038\/mi.2013.28","article-title":"Interleukin-22 binding protein (IL-22BP) is constitutively expressed by a subset of conventional dendritic cells and is strongly induced by retinoic acid","volume":"7","author":"Martin","year":"2014","journal-title":"Mucosal Immunol."},{"key":"2025030614550168900_r31","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1038\/mi.2015.83","article-title":"IL-22BP is produced by eosinophils in human gut and blocks IL-22 protective actions during colitis","volume":"9","author":"Martin","year":"2016","journal-title":"Mucosal Immunol."},{"key":"2025030614550168900_r32","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.freeradbiomed.2008.09.029","article-title":"Mouse model of liver ischemia and reperfusion injury: method for studying reactive oxygen and nitrogen metabolites in vivo","volume":"46","author":"Abe","year":"2009","journal-title":"Free Radic. Biol. Med."},{"key":"2025030614550168900_r33","doi-asserted-by":"crossref","first-page":"5126","DOI":"10.1073\/pnas.0501701102","article-title":"Identifying Foxp3-expressing suppressor T cells with a bicistronic reporter","volume":"102","author":"Wan","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2025030614550168900_r34","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1016\/j.immuni.2011.01.020","article-title":"Th17 cells express interleukin-10 receptor and are controlled by Foxp3\u2212 and Foxp3+ regulatory CD4+ T cells in an interleukin-10-dependent manner","volume":"34","author":"Huber","year":"2011","journal-title":"Immunity"},{"key":"2025030614550168900_r35","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1038\/nature10228","article-title":"Control of TH17 cells occurs in the small intestine","volume":"475","author":"Esplugues","year":"2011","journal-title":"Nature"},{"key":"2025030614550168900_r36","doi-asserted-by":"crossref","first-page":"2114","DOI":"10.1093\/bioinformatics\/btu170","article-title":"Trimmomatic: a flexible trimmer for Illumina sequence data","volume":"30","author":"Bolger","year":"2014","journal-title":"Bioinformatics"},{"key":"2025030614550168900_r37","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1093\/bioinformatics\/bts635","article-title":"STAR: ultrafast universal RNA-seq aligner","volume":"29","author":"Dobin","year":"2013","journal-title":"Bioinformatics"},{"key":"2025030614550168900_r38","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1186\/1471-2105-12-323","article-title":"RSEM: accurate transcript quantification from RNA-Seq data with or without a reference genome","volume":"12","author":"Li","year":"2011","journal-title":"BMC Bioinformatics"},{"key":"2025030614550168900_r39","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biol."},{"key":"2025030614550168900_r40","doi-asserted-by":"crossref","first-page":"2004","DOI":"10.1002\/hep.28492","article-title":"P2X1-regulated IL-22 secretion by innate lymphoid cells is required for efficient liver regeneration","volume":"63","author":"Kudira","year":"2016","journal-title":"Hepatology"},{"key":"2025030614550168900_r41","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1016\/j.bcp.2012.11.004","article-title":"IFN\u03b1 converts IL-22 into a cytokine efficiently activating STAT1 and its downstream targets","volume":"85","author":"Bachmann","year":"2013","journal-title":"Biochem. Pharmacol."},{"key":"2025030614550168900_r42","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.cyto.2016.08.023","article-title":"Role of Interleukin-22 in chronic liver injury","volume":"98","author":"Carmo","year":"2017","journal-title":"Cytokine"},{"key":"2025030614550168900_r43","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1038\/nrd4176","article-title":"Therapeutic opportunities of the IL-22-IL-22R1 system","volume":"13","author":"Sabat","year":"2014","journal-title":"Nat. Rev. Drug Discov."},{"key":"2025030614550168900_r44","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1002\/hep.27629","article-title":"IL-22 and IL-22 binding protein (IL-22BP) regulate fibrosis and cirrhosis in hepatitis C virus and schistosome infections","volume":"61","author":"Sertorio","year":"2015","journal-title":"Hepatology"},{"key":"2025030614550168900_r45","doi-asserted-by":"crossref","first-page":"2512","DOI":"10.4049\/jimmunol.1400588","article-title":"Acute and chronic effects of IL-22 on acetaminophen-induced liver injury","volume":"193","author":"Feng","year":"2014","journal-title":"J. Immunol."},{"key":"2025030614550168900_r46","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1053\/j.gastro.2012.03.044","article-title":"Interleukin-22 promotes proliferation of liver stem\/progenitor cells in mice and patients with chronic hepatitis B virus infection","volume":"143","author":"Feng","year":"2012","journal-title":"Gastroenterology"},{"key":"2025030614550168900_r47","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1097\/TP.0b013e3182449136","article-title":"Interleukin-22: implications for liver ischemia-reperfusion injury","volume":"93","author":"Chestovich","year":"2012","journal-title":"Transplantation"},{"key":"2025030614550168900_r48","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1016\/j.ajpath.2012.12.010","article-title":"Application of interleukin-22 mediates protection in experimental acetaminophen-induced acute liver injury","volume":"182","author":"Scheiermann","year":"2013","journal-title":"Am. J. Pathol."},{"key":"2025030614550168900_r49","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.jhep.2015.08.023","article-title":"ROR\u03b3t(+) IL-22-producing NKp46(+) cells protect from hepatic ischemia reperfusion injury in mice","volume":"64","author":"Eggenhofer","year":"2016","journal-title":"J. Hepatol."},{"key":"2025030614550168900_r50","doi-asserted-by":"crossref","first-page":"2646","DOI":"10.4049\/jimmunol.1600250","article-title":"Transcription factor HIF-1\u03b1 controls expression of the cytokine IL-22 in CD4 T cells","volume":"197","author":"Budda","year":"2016","journal-title":"J. Immunol."},{"key":"2025030614550168900_r51","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1172\/JCI40008","article-title":"Conventional DCs reduce liver ischemia\/reperfusion injury in mice via IL-10 secretion","volume":"120","author":"Bamboat","year":"2010","journal-title":"J. Clin. Invest."},{"key":"2025030614550168900_r52","doi-asserted-by":"crossref","first-page":"1563","DOI":"10.1111\/j.1600-6143.2011.03579.x","article-title":"Liver ischemia and reperfusion injury: new insights into mechanisms of innate-adaptive immune-mediated tissue inflammation","volume":"11","author":"Zhai","year":"2011","journal-title":"Am. J. Transplant."},{"key":"2025030614550168900_r53","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1002\/hep.27037","article-title":"Plasmacytoid dendritic cell-derived IFN-\u03b1 promotes murine liver ischemia\/reperfusion injury by induction of hepatocyte IRF-1","volume":"60","author":"Castellaneta","year":"2014","journal-title":"Hepatology"},{"key":"2025030614550168900_r54","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1002\/hep.21986","article-title":"CXCL10 regulates liver innate immune response against ischemia and reperfusion injury","volume":"47","author":"Zhai","year":"2008","journal-title":"Hepatology"},{"key":"2025030614550168900_r55","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1128\/IAI.01268-15","article-title":"Therapeutic role of interleukin 22 in experimental intra-abdominal Klebsiella pneumoniae infection in mice","volume":"84","author":"Zheng","year":"2016","journal-title":"Infect. Immun."}],"container-title":["The Journal of Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/199\/12\/4078\/61533692\/ji1700587.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/199\/12\/4078\/61533692\/ji1700587.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,6]],"date-time":"2025-03-06T11:58:19Z","timestamp":1741262299000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jimmunol\/article\/199\/12\/4078\/7966248"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,12]]},"references-count":55,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2017,12,15]]}},"URL":"https:\/\/doi.org\/10.4049\/jimmunol.1700587","relation":{},"ISSN":["0022-1767","1550-6606"],"issn-type":[{"value":"0022-1767","type":"print"},{"value":"1550-6606","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2017,12]]},"published":{"date-parts":[[2017,12]]}}}