{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T01:21:28Z","timestamp":1792113688677,"version":"4.4.0"},"reference-count":81,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>No vaccine exists against visceral leishmaniasis. To develop effective vaccines, we have previously reported protective role of live attenuated centrin gene\u2013deleted Leishmania donovani (LdCen\u2212\/\u2212) parasites through induction of Th1 type immune response in mice, hamsters, and dogs. In this study, we specifically explored the role of Th17 cells in LdCen\u2212\/\u2212-induced host protection in mice. Our results showed that compared with wild-type L. donovani infection, LdCen\u2212\/\u2212 parasites induce significantly higher expression of Th17 differentiation cytokines in splenic dendritic cells. There was also induction of IL-17 and its promoting cytokines in total splenocytes and in both CD4 and CD8 T cells following immunization with LdCen\u2212\/\u2212. Upon challenge with wild-type parasites, IL-17 and its differentiating cytokines were significantly higher in LdCen\u2212\/\u2212-immunized mice compared with nonimmunized mice that resulted in parasite control. Alongside IL-17 induction, we observed induction of IFN-\u03b3\u2013producing Th1 cells as reported earlier. However, Th17 cells are generated before Th1 cells. Neutralization of either IL-17 or IFN-\u03b3 abrogated LdCen\u2212\/\u2212-induced host protection further confirming the essential role of Th17 along with Th1 cytokines in host protection. Treatment with recombinant IL-23, which is required for stabilization and maintenance of IL-17, heightened Th17, and Tc17 responses in immunized mice splenocytes. In contrast, Th17 response was absent in immunized IL-23R\u2212\/\u2212 mice that failed to induce protection upon virulent Leishmania challenge suggesting that IL-23 plays an essential role in IL-17\u2013mediated protection by LdCen\u2212\/\u2212 parasites. This study unveiled the role of IL-23\u2013dependent IL-17 induction in LdCen\u2212\/\u2212 parasite-induced immunity and subsequent protection against visceral leishmaniasis.<\/jats:p>","DOI":"10.4049\/jimmunol.1700674","type":"journal-article","created":{"date-parts":[[2017,11,29]],"date-time":"2017-11-29T16:52:44Z","timestamp":1511974364000},"page":"163-176","source":"Crossref","is-referenced-by-count":58,"title":["Live Attenuated <i>Leishmania donovani<\/i> Centrin Gene\u2013Deleted Parasites Induce IL-23\u2013Dependent IL-17\u2013Protective Immune Response against Visceral Leishmaniasis in a Murine Model"],"prefix":"10.1093","volume":"200","author":[{"given":"Antara","family":"Banerjee","sequence":"first","affiliation":[{"name":"Division of Emerging and Transfusion Transmitted Diseases, Office of Blood Research and Review, Center for Biologics Evaluation and Research, Food and Drug Administration , Silver Spring, MD 20993"},{"name":"Department of Zoology, Bangabasi College , Kolkata, 700016 West Bengal,","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Parna","family":"Bhattacharya","sequence":"additional","affiliation":[{"name":"Division of Emerging and Transfusion Transmitted Diseases, Office of Blood Research and Review, Center for Biologics Evaluation and Research, Food and Drug Administration , Silver Spring, MD 20993"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pradeep K","family":"Dagur","sequence":"additional","affiliation":[{"name":"Flow Cytometry Core, National Heart, Lung, and Blood Institute, National Institutes of Health , Bethesda, MD 20892"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Subir","family":"Karmakar","sequence":"additional","affiliation":[{"name":"Division of Emerging and Transfusion Transmitted Diseases, Office of Blood Research and Review, Center for Biologics Evaluation and Research, Food and Drug Administration , Silver Spring, MD 20993"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0294-8834","authenticated-orcid":false,"given":"Nevien","family":"Ismail","sequence":"additional","affiliation":[{"name":"Division of Emerging and Transfusion Transmitted Diseases, Office of Blood Research and Review, Center for Biologics Evaluation and Research, Food and Drug Administration , Silver Spring, MD 20993"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2826-3817","authenticated-orcid":false,"given":"Amritanshu B","family":"Joshi","sequence":"additional","affiliation":[{"name":"Division of Emerging and Transfusion Transmitted Diseases, Office of Blood Research and Review, Center for Biologics Evaluation and Research, Food and Drug Administration , Silver Spring, MD 20993"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adovi D","family":"Akue","sequence":"additional","affiliation":[{"name":"Office of Vaccines Research and Review, Center for Biologics Evaluation and Research, Food and Drug Administration , Silver Spring, MD 20993"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9500-7576","authenticated-orcid":false,"given":"Mark","family":"KuKuruga","sequence":"additional","affiliation":[{"name":"Office of Vaccines Research and Review, Center for Biologics Evaluation and Research, Food and Drug Administration , Silver Spring, MD 20993"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr.","given":"John Philip","family":"McCoy","sequence":"additional","affiliation":[{"name":"Flow Cytometry Core, National Heart, Lung, and Blood Institute, National Institutes of Health , Bethesda, MD 20892"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ranadhir","family":"Dey","sequence":"additional","affiliation":[{"name":"Division of Emerging and Transfusion Transmitted Diseases, Office of Blood Research and Review, Center for Biologics Evaluation and Research, Food and Drug Administration , Silver Spring, MD 20993"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hira L","family":"Nakhasi","sequence":"additional","affiliation":[{"name":"Division of Emerging and Transfusion Transmitted Diseases, Office of Blood Research and Review, Center for Biologics Evaluation and Research, Food and Drug Administration , Silver Spring, MD 20993"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2018,1,1]]},"reference":[{"key":"2025030610003302200_r1","doi-asserted-by":"crossref","first-page":"e0003527","DOI":"10.1371\/journal.pntd.0003527","article-title":"Health economic evaluations of visceral leishmaniasis treatments: a systematic review","volume":"9","author":"Marinho","year":"2015","journal-title":"PLoS Negl. 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