{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T09:02:21Z","timestamp":1790326941626,"version":"4.1.0"},"reference-count":78,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2018,6,1]],"date-time":"2018-06-01T00:00:00Z","timestamp":1527811200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Nonsteroidal anti-inflammatory drugs (NSAIDs) inhibit cyclooxygenase (COX) activity and are commonly used for pain relief and fever reduction. NSAIDs are used following childhood vaccinations and cancer immunotherapies; however, how NSAIDs influence the development of immunity following these therapies is unknown. We hypothesized that NSAIDs would modulate the development of an immune response to Listeria monocytogenes\u2013based immunotherapy. Treatment of mice with the nonspecific COX inhibitor indomethacin impaired the generation of cell-mediated immunity. This phenotype was due to inhibition of the inducible COX-2 enzyme, as treatment with the COX-2\u2013selective inhibitor celecoxib similarly inhibited the development of immunity. In contrast, loss of COX-1 activity improved immunity to L. monocytogenes. Impairments in immunity were independent of bacterial burden, dendritic cell costimulation, or innate immune cell infiltrate. Instead, we observed that PGE2 production following L. monocytogenes is critical for the formation of an Ag-specific CD8+ T cell response. Use of the alternative analgesic acetaminophen did not impair immunity. Taken together, our results suggest that COX-2 is necessary for optimal CD8+ T cell responses to L. monocytogenes, whereas COX-1 is detrimental. Use of pharmacotherapies that spare COX-2 activity and the production of PGE2 like acetaminophen will be critical for the generation of optimal antitumor responses using L. monocytogenes.<\/jats:p>","DOI":"10.4049\/jimmunol.1700701","type":"journal-article","created":{"date-parts":[[2018,4,20]],"date-time":"2018-04-20T14:30:16Z","timestamp":1524234616000},"page":"3729-3738","source":"Crossref","is-referenced-by-count":16,"title":["Cyclooxygenase-1 and -2 Play Contrasting Roles in <i>Listeria<\/i>-Stimulated Immunity"],"prefix":"10.1093","volume":"200","author":[{"given":"Erin","family":"Theisen","sequence":"first","affiliation":[{"name":"Department of Medical Microbiology and Immunology, University of Wisconsin-Madison , Madison, WI 53706"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Courtney E","family":"McDougal","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology and Immunology, University of Wisconsin-Madison , Madison, WI 53706"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masako","family":"Nakanishi","sequence":"additional","affiliation":[{"name":"Center for Molecular Medicine, University of Connecticut Health Center , Farmington, CT 06030"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David M","family":"Stevenson","sequence":"additional","affiliation":[{"name":"Department of Bacteriology, University of Wisconsin-Madison , Madison, WI 53706"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Amador-Noguez","sequence":"additional","affiliation":[{"name":"Department of Bacteriology, University of Wisconsin-Madison , Madison, WI 53706"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2897-2613","authenticated-orcid":false,"given":"Daniel W","family":"Rosenberg","sequence":"additional","affiliation":[{"name":"Center for Molecular Medicine, University of Connecticut Health Center , Farmington, CT 06030"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura J","family":"Knoll","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology and Immunology, University of Wisconsin-Madison , Madison, WI 53706"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9367-794X","authenticated-orcid":false,"given":"John-Demian","family":"Sauer","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology and Immunology, University of Wisconsin-Madison , Madison, WI 53706"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2018,6,1]]},"reference":[{"key":"2025030610151413600_r1","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1146\/annurev-med-112311-083918","article-title":"Harnessing the power of the immune system to target cancer","volume":"64","author":"Liz\u00e9e","year":"2013","journal-title":"Annu. 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