{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T13:58:46Z","timestamp":1768485526001,"version":"3.49.0"},"reference-count":60,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2017,10,1]],"date-time":"2017-10-01T00:00:00Z","timestamp":1506816000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Klhl6 belongs to the KLHL gene family, which is composed of an N-terminal BTB-POZ domain and four to six Kelch motifs in tandem. Several of these proteins function as adaptors of the Cullin3 E3 ubiquitin ligase complex. In this article, we report that Klhl6 deficiency induces, as previously described, a 2-fold reduction in mature B cells. However, we find that this deficit is centered on the inability of transitional type 1 B cells to survive and to progress toward the transitional type 2 B cell stage, whereas cells that have passed this step generate normal germinal centers (GCs) upon a T-dependent immune challenge. Klhl6-deficient type 1 B cells showed a 2-fold overexpression of genes linked with cell proliferation, including most targets of the anaphase-promoting complex\/cyclosome complex, a set of genes whose expression is precisely downmodulated upon culture of splenic transitional B cells in the presence of BAFF. These results thus suggest a delay in the differentiation process of Klhl6-deficient B cells between the immature and transitional stage. We further show, in the BL2 Burkitt\u2019s lymphoma cell line, that KLHL6 interacts with Cullin3, but also that it binds to HBXIP\/Lamtor5, a protein involved in cell-cycle regulation and cytokinesis. Finally, we report that KLHL6, which is recurrently mutated in B cell lymphomas, is an off-target of the normal somatic hypermutation process taking place in GC B cells in both mice and humans, thus leaving open whether, despite the lack of impact of Klhl6 deficiency on GC B cell expansion, mutants could contribute to the oncogenic process.<\/jats:p>","DOI":"10.4049\/jimmunol.1700708","type":"journal-article","created":{"date-parts":[[2017,8,15]],"date-time":"2017-08-15T00:30:20Z","timestamp":1502757020000},"page":"2408-2420","source":"Crossref","is-referenced-by-count":23,"title":["Klhl6 Deficiency Impairs Transitional B Cell Survival and Differentiation"],"prefix":"10.1093","volume":"199","author":[{"given":"Barbara","family":"Bertocci","sequence":"first","affiliation":[{"name":"\u00c9quipe D\u00e9veloppement du Syst\u00e9me Immunitaire, Institut Necker-Enfant Malades, INSERM U1151-CNRS UMR8253, Facult\u00e9 de M\u00e9decine Paris Decartes, Universit\u00e9 Paris Descartes, Sorbone Paris Cit\u00e9 , 75993 Paris Cedex 14,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Damiana","family":"Lecoeuche","sequence":"additional","affiliation":[{"name":"\u00c9quipe D\u00e9veloppement du Syst\u00e9me Immunitaire, Institut Necker-Enfant Malades, INSERM U1151-CNRS UMR8253, Facult\u00e9 de M\u00e9decine Paris Decartes, Universit\u00e9 Paris Descartes, Sorbone Paris Cit\u00e9 , 75993 Paris Cedex 14,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Delphine","family":"Sterlin","sequence":"additional","affiliation":[{"name":"\u00c9quipe D\u00e9veloppement du Syst\u00e9me Immunitaire, Institut Necker-Enfant Malades, INSERM U1151-CNRS UMR8253, Facult\u00e9 de M\u00e9decine Paris Decartes, Universit\u00e9 Paris Descartes, Sorbone Paris Cit\u00e9 , 75993 Paris Cedex 14,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julius","family":"K\u00fchn","sequence":"additional","affiliation":[{"name":"Institute of Cellular and Molecular Immunology, Georg-August-University Medicine G\u00f6ttingen , 37073 G\u00f6ttingen,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Baptiste","family":"Gaillard","sequence":"additional","affiliation":[{"name":"\u00c9quipe D\u00e9veloppement du Syst\u00e9me Immunitaire, Institut Necker-Enfant Malades, INSERM U1151-CNRS UMR8253, Facult\u00e9 de M\u00e9decine Paris Decartes, Universit\u00e9 Paris Descartes, Sorbone Paris Cit\u00e9 , 75993 Paris Cedex 14,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annie","family":"De Smet","sequence":"additional","affiliation":[{"name":"\u00c9quipe D\u00e9veloppement du Syst\u00e9me Immunitaire, Institut Necker-Enfant Malades, INSERM U1151-CNRS UMR8253, Facult\u00e9 de M\u00e9decine Paris Decartes, Universit\u00e9 Paris Descartes, Sorbone Paris Cit\u00e9 , 75993 Paris Cedex 14,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frederique","family":"Lembo","sequence":"additional","affiliation":[{"name":"Centre de Recherche en Canc\u00e9rologie de Marseille, INSERM U1068-CNRS UMR7258 , 13273 Marseille Cedex 09,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christine","family":"Bole-Feysot","sequence":"additional","affiliation":[{"name":"Plateforme de G\u00e9nomique, Imagine Institut des Maladies G\u00e9n\u00e9tiques-Structure F\u00e9d\u00e9rative de Recherche Necker, INSERM 1163 and INSERM US24\/CNRS UMS3633 , 75015 Paris,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicolas","family":"Cagnard","sequence":"additional","affiliation":[{"name":"Plateforme de Bioinformatique, Universit\u00e9 Paris Descartes-Structure F\u00e9d\u00e9rative de Recherche Necker, INSERM US24\/CNRS UMS3633 , 75993 Paris Cedex 14,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5532-9431","authenticated-orcid":false,"given":"Tatiana","family":"Fadeev","sequence":"additional","affiliation":[{"name":"\u00c9quipe D\u00e9veloppement du Syst\u00e9me Immunitaire, Institut Necker-Enfant Malades, INSERM U1151-CNRS UMR8253, Facult\u00e9 de M\u00e9decine Paris Decartes, Universit\u00e9 Paris Descartes, Sorbone Paris Cit\u00e9 , 75993 Paris Cedex 14,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Auriel","family":"Dahan","sequence":"additional","affiliation":[{"name":"\u00c9quipe D\u00e9veloppement du Syst\u00e9me Immunitaire, Institut Necker-Enfant Malades, INSERM U1151-CNRS UMR8253, Facult\u00e9 de M\u00e9decine Paris Decartes, Universit\u00e9 Paris Descartes, Sorbone Paris Cit\u00e9 , 75993 Paris Cedex 14,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean-Claude","family":"Weill","sequence":"additional","affiliation":[{"name":"\u00c9quipe D\u00e9veloppement du Syst\u00e9me Immunitaire, Institut Necker-Enfant Malades, INSERM U1151-CNRS UMR8253, Facult\u00e9 de M\u00e9decine Paris Decartes, Universit\u00e9 Paris Descartes, Sorbone Paris Cit\u00e9 , 75993 Paris Cedex 14,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4519-4473","authenticated-orcid":false,"given":"Claude-Agn\u00e8s","family":"Reynaud","sequence":"additional","affiliation":[{"name":"\u00c9quipe D\u00e9veloppement du Syst\u00e9me Immunitaire, Institut Necker-Enfant Malades, INSERM U1151-CNRS UMR8253, Facult\u00e9 de M\u00e9decine Paris Decartes, Universit\u00e9 Paris Descartes, Sorbone Paris Cit\u00e9 , 75993 Paris Cedex 14,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2017,10,1]]},"reference":[{"key":"2025030614455011700_r1","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1038\/337562a0","article-title":"Clonal deletion of B lymphocytes in a transgenic mouse bearing anti-MHC class I antibody genes","volume":"337","author":"Nemazee","year":"1989","journal-title":"Nature"},{"key":"2025030614455011700_r2","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1038\/nature03724","article-title":"Cellular and genetic mechanisms of self tolerance and autoimmunity","volume":"435","author":"Goodnow","year":"2005","journal-title":"Nature"},{"key":"2025030614455011700_r3","doi-asserted-by":"crossref","first-page":"4431","DOI":"10.4049\/jimmunol.151.9.4431","article-title":"Peripheral B cell maturation. II. Heat-stable antigen(hi) splenic B cells are an immature developmental intermediate in the production of long-lived marrow-derived B cells","volume":"151","author":"Allman","year":"1993","journal-title":"J. Immunol."},{"key":"2025030614455011700_r4","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1084\/jem.190.1.75","article-title":"B cell development in the spleen takes place in discrete steps and is determined by the quality of B cell receptor-derived signals","volume":"190","author":"Loder","year":"1999","journal-title":"J. Exp. Med."},{"key":"2025030614455011700_r5","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/S1471-4906(03)00119-4","article-title":"Transitional B cells: step by step towards immune competence","volume":"24","author":"Chung","year":"2003","journal-title":"Trends Immunol."},{"key":"2025030614455011700_r6","doi-asserted-by":"crossref","first-page":"6834","DOI":"10.4049\/jimmunol.167.12.6834","article-title":"Resolution of three nonproliferative immature splenic B cell subsets reveals multiple selection points during peripheral B cell maturation","volume":"167","author":"Allman","year":"2001","journal-title":"J. Immunol."},{"key":"2025030614455011700_r7","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1093\/intimm\/14.2.157","article-title":"CD23 defines two distinct subsets of immature B cells which differ in their responses to T cell help signals","volume":"14","author":"Chung","year":"2002","journal-title":"Int. Immunol."},{"key":"2025030614455011700_r8","doi-asserted-by":"crossref","first-page":"3738","DOI":"10.1002\/(SICI)1521-4141(199811)28:11<3738::AID-IMMU3738>3.0.CO;2-Q","article-title":"Characterization of immature B cells by a novel monoclonal antibody, by turnover and by mitogen reactivity","volume":"28","author":"Rolink","year":"1998","journal-title":"Eur. J. Immunol."},{"key":"2025030614455011700_r9","doi-asserted-by":"crossref","first-page":"2339","DOI":"10.1182\/blood-2006-05-021089","article-title":"Naive recirculating B cells mature simultaneously in the spleen and bone marrow","volume":"109","author":"Cariappa","year":"2007","journal-title":"Blood"},{"key":"2025030614455011700_r10","doi-asserted-by":"crossref","first-page":"2521","DOI":"10.1182\/blood-2006-04-018085","article-title":"Generation of peripheral B cells occurs via two spatially and temporally distinct pathways","volume":"109","author":"Lindsley","year":"2007","journal-title":"Blood"},{"key":"2025030614455011700_r11","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.cellimm.2006.04.007","article-title":"Regulation of peripheral B cell maturation","volume":"239","author":"Thomas","year":"2006","journal-title":"Cell. Immunol."},{"key":"2025030614455011700_r12","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1038\/icb.2008.89","article-title":"The bone marrow perisinusoidal niche for recirculating B cells and the positive selection of bone marrow-derived B lymphocytes","volume":"87","author":"Pillai","year":"2009","journal-title":"Immunol. Cell Biol."},{"key":"2025030614455011700_r13","doi-asserted-by":"crossref","first-page":"2111","DOI":"10.1126\/science.1061964","article-title":"An essential role for BAFF in the normal development of B cells through a BCMA-independent pathway","volume":"293","author":"Schiemann","year":"2001","journal-title":"Science"},{"key":"2025030614455011700_r14","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.1084\/jem.192.10.1453","article-title":"BAFF mediates survival of peripheral immature B lymphocytes","volume":"192","author":"Batten","year":"2000","journal-title":"J. Exp. Med."},{"key":"2025030614455011700_r15","doi-asserted-by":"crossref","first-page":"2245","DOI":"10.4049\/jimmunol.173.4.2245","article-title":"TNF family member B cell-activating factor (BAFF) receptor-dependent and -independent roles for BAFF in B cell physiology","volume":"173","author":"Sasaki","year":"2004","journal-title":"J. Immunol."},{"key":"2025030614455011700_r16","doi-asserted-by":"crossref","first-page":"1547","DOI":"10.1016\/S0960-9822(01)00481-X","article-title":"Identification of a novel receptor for B lymphocyte stimulator that is mutated in a mouse strain with severe B cell deficiency","volume":"11","author":"Yan","year":"2001","journal-title":"Curr. Biol."},{"key":"2025030614455011700_r17","doi-asserted-by":"crossref","first-page":"5993","DOI":"10.4049\/jimmunol.168.12.5993","article-title":"Cutting edge: BLyS enables survival of transitional and mature B cells through distinct mediators","volume":"168","author":"Hsu","year":"2002","journal-title":"J. Immunol."},{"key":"2025030614455011700_r18","doi-asserted-by":"crossref","first-page":"e5456","DOI":"10.1371\/journal.pone.0005456","article-title":"Crucial role for BAFF-BAFF-R signaling in the survival and maintenance of mature B cells","volume":"4","author":"Rauch","year":"2009","journal-title":"PLoS One"},{"key":"2025030614455011700_r19","doi-asserted-by":"crossref","first-page":"2331","DOI":"10.4049\/jimmunol.173.4.2331","article-title":"B cell-activating factor belonging to the TNF family acts through separate receptors to support B cell survival and T cell-independent antibody formation","volume":"173","author":"Shulga-Morskaya","year":"2004","journal-title":"J. Immunol."},{"key":"2025030614455011700_r20","doi-asserted-by":"crossref","first-page":"4570","DOI":"10.4049\/jimmunol.1001708","article-title":"BAFF receptor signaling aids the differentiation of immature B cells into transitional B cells following tonic BCR signaling","volume":"185","author":"Rowland","year":"2010","journal-title":"J. Immunol."},{"key":"2025030614455011700_r21","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/1479-7364-7-13","article-title":"Update on the Kelch-like (KLHL) gene family","volume":"7","author":"Dhanoa","year":"2013","journal-title":"Hum. Genomics"},{"key":"2025030614455011700_r22","first-page":"1193","article-title":"The BTB\/POZ domain: a new protein-protein interaction motif common to DNA- and actin-binding proteins","volume":"6","author":"Albagli","year":"1995","journal-title":"Cell Growth Differ."},{"key":"2025030614455011700_r23","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1016\/j.tibs.2004.10.003","article-title":"The BACK domain in BTB-kelch proteins","volume":"29","author":"Stogios","year":"2004","journal-title":"Trends Biochem. Sci."},{"key":"2025030614455011700_r24","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/S0962-8924(99)01673-6","article-title":"The kelch repeat superfamily of proteins: propellers of cell function","volume":"10","author":"Adams","year":"2000","journal-title":"Trends Cell Biol."},{"key":"2025030614455011700_r25","doi-asserted-by":"crossref","first-page":"7803","DOI":"10.1074\/jbc.M112.437996","article-title":"Structural basis for Cul3 protein assembly with the BTB-Kelch family of E3 ubiquitin ligases. [Published erratum appears in 2013 J. Biol. Chem. 288: 28304.]","volume":"288","author":"Canning","year":"2013","journal-title":"J. Biol. Chem."},{"key":"2025030614455011700_r26","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.molcel.2009.07.025","article-title":"KEAP1 E3 ligase-mediated downregulation of NF-kappaB signaling by targeting IKKbeta","volume":"36","author":"Lee","year":"2009","journal-title":"Mol. Cell"},{"key":"2025030614455011700_r27","doi-asserted-by":"crossref","first-page":"1748","DOI":"10.1038\/emboj.2010.62","article-title":"The Cullin 3 substrate adaptor KLHL20 mediates DAPK ubiquitination to control interferon responses","volume":"29","author":"Lee","year":"2010","journal-title":"EMBO J."},{"key":"2025030614455011700_r28","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1083\/jcb.200906117","article-title":"The Cul3-KLHL21 E3 ubiquitin ligase targets aurora B to midzone microtubules in anaphase and is required for cytokinesis","volume":"187","author":"Maerki","year":"2009","journal-title":"J. Cell Biol."},{"key":"2025030614455011700_r29","doi-asserted-by":"crossref","first-page":"7793","DOI":"10.1073\/pnas.0308025101","article-title":"Haploinsufficiency of kelch-like protein homolog 10 causes infertility in male mice","volume":"101","author":"Yan","year":"2004","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2025030614455011700_r30","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.ajhg.2013.05.004","article-title":"Mutations in KLHL40 are a frequent cause of severe autosomal-recessive nemaline myopathy","volume":"93","author":"Ravenscroft","year":"2013","journal-title":"Am. J. Hum. Genet."},{"key":"2025030614455011700_r31","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1016\/S0161-5890(03)00002-6","article-title":"Specific over-expression of deltex and a new Kelch-like protein in human germinal center B cells","volume":"39","author":"Gupta-Rossi","year":"2003","journal-title":"Mol. Immunol."},{"key":"2025030614455011700_r32","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1038\/nature10351","article-title":"Frequent mutation of histone-modifying genes in non-Hodgkin lymphoma","volume":"476","author":"Morin","year":"2011","journal-title":"Nature"},{"key":"2025030614455011700_r33","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1038\/nature10113","article-title":"Whole-genome sequencing identifies recurrent mutations in chronic lymphocytic leukaemia","volume":"475","author":"Puente","year":"2011","journal-title":"Nature"},{"key":"2025030614455011700_r34","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1038\/nature14666","article-title":"Non-coding recurrent mutations in chronic lymphocytic leukaemia","volume":"526","author":"Puente","year":"2015","journal-title":"Nature"},{"key":"2025030614455011700_r35","doi-asserted-by":"crossref","first-page":"8531","DOI":"10.1128\/MCB.25.19.8531-8540.2005","article-title":"The BTB-kelch protein KLHL6 is involved in B-lymphocyte antigen receptor signaling and germinal center formation","volume":"25","author":"Kroll","year":"2005","journal-title":"Mol. Cell. Biol."},{"key":"2025030614455011700_r36","doi-asserted-by":"crossref","first-page":"1292","DOI":"10.1038\/ni.1814","article-title":"Multiple layers of B cell memory with different effector functions","volume":"10","author":"Dogan","year":"2009","journal-title":"Nat. Immunol."},{"key":"2025030614455011700_r37","doi-asserted-by":"crossref","first-page":"2022","DOI":"10.1073\/pnas.0409491102","article-title":"DNA cleavage in immunoglobulin somatic hypermutation depends on de novo protein synthesis but not on uracil DNA glycosylase","volume":"102","author":"Nagaoka","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2025030614455011700_r38","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1006\/meth.2001.1190","article-title":"High-throughput yeast two-hybrid assays for large-scale protein interaction mapping","volume":"24","author":"Walhout","year":"2001","journal-title":"Methods"},{"key":"2025030614455011700_r39","doi-asserted-by":"crossref","first-page":"6405","DOI":"10.4049\/jimmunol.176.11.6405","article-title":"Space, selection, and surveillance: setting boundaries with BLyS","volume":"176","author":"Miller","year":"2006","journal-title":"J. Immunol."},{"key":"2025030614455011700_r40","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1002\/eji.201141957","article-title":"BAFF-R expression correlates with positive selection of immature B cells","volume":"42","author":"Tussiwand","year":"2012","journal-title":"Eur. J. Immunol."},{"key":"2025030614455011700_r41","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1038\/ni842","article-title":"BAFF-induced NEMO-independent processing of NF-kappa B2 in maturing B cells","volume":"3","author":"Claudio","year":"2002","journal-title":"Nat. Immunol."},{"key":"2025030614455011700_r42","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1042\/BST0380065","article-title":"The anaphase-promoting complex\/cyclosome (APC\/C): cell-cycle-dependent and -independent functions","volume":"38","author":"Manchado","year":"2010","journal-title":"Biochem. Soc. Trans."},{"key":"2025030614455011700_r43","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1038\/nrm3934","article-title":"Spatiotemporal regulation of the anaphase-promoting complex in mitosis","volume":"16","author":"Sivakumar","year":"2015","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"2025030614455011700_r44","doi-asserted-by":"crossref","first-page":"25621","DOI":"10.1074\/jbc.M503162200","article-title":"Membrane cholesterol content accounts for developmental differences in surface B cell receptor compartmentalization and signaling","volume":"280","author":"Karnell","year":"2005","journal-title":"J. Biol. Chem."},{"key":"2025030614455011700_r45","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.semcdb.2014.12.007","article-title":"Survivin - the inconvenient IAP","volume":"39","author":"Altieri","year":"2015","journal-title":"Semin. Cell Dev. Biol."},{"key":"2025030614455011700_r46","doi-asserted-by":"crossref","first-page":"1737","DOI":"10.1128\/JVI.72.3.1737-1743.1998","article-title":"Cloning and characterization of a novel hepatitis B virus x binding protein that inhibits viral replication","volume":"72","author":"Melegari","year":"1998","journal-title":"J. Virol."},{"key":"2025030614455011700_r47","doi-asserted-by":"crossref","first-page":"1196","DOI":"10.1016\/j.cell.2012.07.032","article-title":"Ragulator is a GEF for the rag GTPases that signal amino acid levels to mTORC1","volume":"150","author":"Bar-Peled","year":"2012","journal-title":"Cell"},{"key":"2025030614455011700_r48","doi-asserted-by":"crossref","first-page":"2793","DOI":"10.1074\/jbc.M708419200","article-title":"Interaction of hepatitis B viral oncoprotein with cellular target HBXIP dysregulates centrosome dynamics and mitotic spindle formation","volume":"283","author":"Wen","year":"2008","journal-title":"J. Biol. Chem."},{"key":"2025030614455011700_r49","doi-asserted-by":"crossref","first-page":"2729","DOI":"10.1093\/emboj\/cdg263","article-title":"HBXIP functions as a cofactor of survivin in apoptosis suppression","volume":"22","author":"Marusawa","year":"2003","journal-title":"EMBO J."},{"key":"2025030614455011700_r50","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1038\/ni.1964","article-title":"Deep-sequencing identification of the genomic targets of the cytidine deaminase AID and its cofactor RPA in B lymphocytes","volume":"12","author":"Yamane","year":"2011","journal-title":"Nat. Immunol."},{"key":"2025030614455011700_r51","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1038\/nature06547","article-title":"Two levels of protection for the B cell genome during somatic hypermutation","volume":"451","author":"Liu","year":"2008","journal-title":"Nature"},{"key":"2025030614455011700_r52","doi-asserted-by":"crossref","first-page":"11816","DOI":"10.1073\/pnas.95.20.11816","article-title":"BCL-6 mutations in normal germinal center B cells: evidence of somatic hypermutation acting outside Ig loci","volume":"95","author":"Pasqualucci","year":"1998","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2025030614455011700_r53","doi-asserted-by":"crossref","first-page":"1750","DOI":"10.1126\/science.280.5370.1750","article-title":"Mutation of BCL-6 gene in normal B cells by the process of somatic hypermutation of Ig genes","volume":"280","author":"Shen","year":"1998","journal-title":"Science"},{"key":"2025030614455011700_r54","doi-asserted-by":"crossref","first-page":"1833","DOI":"10.1084\/jem.192.12.1833","article-title":"Somatic mutation of the CD95 gene in human B cells as a side-effect of the germinal center reaction","volume":"192","author":"M\u00fcschen","year":"2000","journal-title":"J. Exp. Med."},{"key":"2025030614455011700_r55","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1038\/ni.1666","article-title":"Tonic B cell antigen receptor signals supply an NF-kappaB substrate for prosurvival BLyS signaling","volume":"9","author":"Stadanlick","year":"2008","journal-title":"Nat. Immunol."},{"key":"2025030614455011700_r56","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1016\/j.immuni.2006.04.005","article-title":"Canonical NF-kappaB activity, dispensable for B cell development, replaces BAFF-receptor signals and promotes B cell proliferation upon activation","volume":"24","author":"Sasaki","year":"2006","journal-title":"Immunity"},{"key":"2025030614455011700_r57","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.jmb.2010.10.046","article-title":"Structural characterization of HBXIP: the protein that interacts with the anti-apoptotic protein survivin and the oncogenic viral protein HBx","volume":"405","author":"Garcia-Saez","year":"2011","journal-title":"J. Mol. Biol."},{"key":"2025030614455011700_r58","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1016\/j.devcel.2007.03.019","article-title":"A Cul3-based E3 ligase removes Aurora B from mitotic chromosomes, regulating mitotic progression and completion of cytokinesis in human cells","volume":"12","author":"Sumara","year":"2007","journal-title":"Dev. Cell"},{"key":"2025030614455011700_r59","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/2044-5040-4-11","article-title":"Kelch proteins: emerging roles in skeletal muscle development and diseases","volume":"4","author":"Gupta","year":"2014","journal-title":"Skelet. Muscle"},{"key":"2025030614455011700_r60","doi-asserted-by":"crossref","first-page":"2122","DOI":"10.1182\/blood-2015-07-659144","article-title":"Clinical impact of clonal and subclonal TP53, SF3B1, BIRC3, NOTCH1, and ATM mutations in chronic lymphocytic leukemia","volume":"127","author":"Nadeu","year":"2016","journal-title":"Blood"}],"container-title":["The Journal of Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/199\/7\/2408\/61593183\/ji1700708.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/199\/7\/2408\/61593183\/ji1700708.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,6]],"date-time":"2025-03-06T16:43:29Z","timestamp":1741279409000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jimmunol\/article\/199\/7\/2408\/7977136"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,10,1]]},"references-count":60,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2017,10,1]]}},"URL":"https:\/\/doi.org\/10.4049\/jimmunol.1700708","relation":{},"ISSN":["0022-1767","1550-6606"],"issn-type":[{"value":"0022-1767","type":"print"},{"value":"1550-6606","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2017,10]]},"published":{"date-parts":[[2017,10,1]]}}}