{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T15:45:12Z","timestamp":1790783112611,"version":"4.1.0"},"reference-count":60,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2017,10,1]],"date-time":"2017-10-01T00:00:00Z","timestamp":1506816000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Biallelic mutations of three prime repair exonuclease 1 (TREX1) cause the lupus-like disease Aicardi\u2013Gouti\u00e8res syndrome in which accumulation of a yet unknown endogenous DNA substrate of TREX1 triggers a cyclic GMP\u2013AMP synthase-dependent type I IFN response and systemic autoimmunity. Products of reverse transcription originating from endogenous retroelements have been suggested to be a major substrate for TREX1, and reverse transcriptase inhibitors (RTIs) were proposed as a therapeutic option in autoimmunity ensuing from defects of TREX1. In this study, we treated Trex1\u2212\/\u2212 mice with RTIs. The serum RTI levels reached were sufficient to block retrotransposition of endogenous retroelements. However, the treatment did not reduce the spontaneous type I IFN response and did not ameliorate lethal inflammation. Furthermore, long interspersed nuclear elements 1 retrotransposition was not enhanced in the absence of Trex1. Our data do not support the concept of retroelement-derived cDNA as key triggers of systemic autoimmunity in Trex1-deficient humans and mice and motivate the continuing search for the pathogenic IFN-inducing Trex1 substrate.<\/jats:p>","DOI":"10.4049\/jimmunol.1700714","type":"journal-article","created":{"date-parts":[[2017,8,24]],"date-time":"2017-08-24T00:40:31Z","timestamp":1503535231000},"page":"2261-2269","source":"Crossref","is-referenced-by-count":40,"title":["Lack of Trex1 Causes Systemic Autoimmunity despite the Presence of Antiretroviral Drugs"],"prefix":"10.1093","volume":"199","author":[{"given":"Martin","family":"Achleitner","sequence":"first","affiliation":[{"name":"Institute for Immunology, Medical Faculty Carl Gustav Carus, Technical University of Dresden , 01307 Dresden,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3973-344X","authenticated-orcid":false,"given":"Martin","family":"Kleefisch","sequence":"additional","affiliation":[{"name":"Institute for Immunology, Medical Faculty Carl Gustav Carus, Technical University of Dresden , 01307 Dresden,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Hennig","sequence":"additional","affiliation":[{"name":"Institute for Immunology, Medical Faculty Carl Gustav Carus, Technical University of Dresden , 01307 Dresden,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katrin","family":"Peschke","sequence":"additional","affiliation":[{"name":"Institute for Immunology, Medical Faculty Carl Gustav Carus, Technical University of Dresden , 01307 Dresden,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9788-5057","authenticated-orcid":false,"given":"Anastasia","family":"Polikarpova","sequence":"additional","affiliation":[{"name":"Institute for Immunology, Medical Faculty Carl Gustav Carus, Technical University of Dresden , 01307 Dresden,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reinhard","family":"Oertel","sequence":"additional","affiliation":[{"name":"Institute of Clinical Pharmacology, Medical Faculty Carl Gustav Carus, Technical University of Dresden , 01307 Dresden,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0762-9082","authenticated-orcid":false,"given":"Benjamin","family":"Gabriel","sequence":"additional","affiliation":[{"name":"Division for HIV and Other Retroviruses, Department of Infectious Diseases, Robert Koch Institute , 13353 Berlin,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Livia","family":"Schulze","sequence":"additional","affiliation":[{"name":"Institute for Immunology, Medical Faculty Carl Gustav Carus, Technical University of Dresden , 01307 Dresden,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0320-4223","authenticated-orcid":false,"given":"Dirk","family":"Lindeman","sequence":"additional","affiliation":[{"name":"Institute of Virology, Medical Faculty Carl Gustav Carus, Technical University of Dresden , 01307 Dresden,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Gerbaulet","sequence":"additional","affiliation":[{"name":"Institute for Immunology, Medical Faculty Carl Gustav Carus, Technical University of Dresden , 01307 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Dresden,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1091-2877","authenticated-orcid":false,"given":"Rayk","family":"Behrendt","sequence":"additional","affiliation":[{"name":"Institute for Immunology, Medical Faculty Carl Gustav Carus, Technical University of Dresden , 01307 Dresden,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2017,10,1]]},"reference":[{"key":"2025030614472536500_r1","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1038\/nri3850","article-title":"Aicardi\u2013Gouti\u00e8res syndrome and the type I interferonopathies","volume":"15","author":"Crow","year":"2015","journal-title":"Nat. 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