{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T00:54:24Z","timestamp":1789692864962,"version":"4.0.1"},"reference-count":55,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2017,9,1]],"date-time":"2017-09-01T00:00:00Z","timestamp":1504224000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The innate immune components that modulate allergic contact hypersensitivity (CHS) responses are poorly defined. Using human skin from contact dermatitis patients and a mouse model of CHS, we find that hapten allergens disrupt the Arginase1 (Arg1) and inducible NO synthase (iNOS) dynamic in monocytes\/macrophages (mono\/M\u03a6), which renders those cells ineffectual in suppressing skin inflammation. Mice lacking Arg1 in M\u03a6 develop increased CHS characterized by elevated ear thickening, mono\/M\u03a6\u2212dominated dermal inflammation, and increased iNOS and IL-6 expression compared with control mice. Treatment of Arg1flox\/flox; LysMCre+\/\u2212 mice with a selective NOS inhibitor or knockout of Nos2, encoding iNOS, significantly ameliorates CHS. Our findings suggest a critical role for Arg1 in mono\/M\u03a6 in suppressing CHS through dampening Nos2 expression. These results support that increasing Arg1 may be a potential therapeutic avenue in treating allergic contact dermatitis.<\/jats:p>","DOI":"10.4049\/jimmunol.1700739","type":"journal-article","created":{"date-parts":[[2017,7,27]],"date-time":"2017-07-27T00:25:35Z","timestamp":1501115135000},"page":"1827-1834","source":"Crossref","is-referenced-by-count":41,"title":["Arginase1 Deficiency in Monocytes\/Macrophages Upregulates Inducible Nitric Oxide Synthase To Promote Cutaneous Contact Hypersensitivity"],"prefix":"10.1093","volume":"199","author":[{"given":"Jutamas","family":"Suwanpradid","sequence":"first","affiliation":[{"name":"Department of Dermatology, Duke University , Durham, NC 27710"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2972-637X","authenticated-orcid":false,"given":"Michael","family":"Shih","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Duke University , Durham, NC 27710"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren","family":"Pontius","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Duke University , Durham, NC 27710"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3842-6395","authenticated-orcid":false,"given":"Bin","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Duke University , Durham, NC 27710"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anastasiya","family":"Birukova","sequence":"additional","affiliation":[{"name":"Department of Medicine, Duke University , Durham, NC 27710"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emma","family":"Guttman-Yassky","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Icahn School of Medicine, Mount Sinai Medical Center , New York, NY 10029"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David L","family":"Corcoran","sequence":"additional","affiliation":[{"name":"Center for Genomic and Computational Biology, Duke University , Durham, NC 27708"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9188-9244","authenticated-orcid":false,"given":"Loretta G","family":"Que","sequence":"additional","affiliation":[{"name":"Department of Medicine, Duke University , Durham, NC 27710"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert M","family":"Tighe","sequence":"additional","affiliation":[{"name":"Department of Medicine, Duke University , Durham, NC 27710"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8139-9110","authenticated-orcid":false,"given":"Amanda S","family":"MacLeod","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Duke University , Durham, NC 27710"},{"name":"Duke Immunology, Duke University , Durham, NC 27710"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2017,9,1]]},"reference":[{"key":"2025030614300132600_r1","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1007\/s00420-002-0419-0","article-title":"Occupational issues of irritant contact dermatitis","volume":"76","author":"Chew","year":"2003","journal-title":"Int. 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