{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T17:30:26Z","timestamp":1792085426767,"version":"4.4.0"},"reference-count":26,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2017,12,1]],"date-time":"2017-12-01T00:00:00Z","timestamp":1512086400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,12,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>APCs are known to produce NADPH oxidase (NOX) 2\u2013derived reactive oxygen species; however, whether and how NOX2-mediated oxidation affects redox-sensitive immunogenic peptides remains elusive. In this study, we investigated a major immunogenic peptide in glucose-6-phosphate isomerase (G6PI), a potential autoantigen in rheumatoid arthritis, which can form internal disulfide bonds. Ag presentation assays showed that presentation of this G6PI peptide was more efficient in NOX2-deficient (Ncf1m1J\/m1J mutant) mice, compared with wild-type controls. IFN-\u03b3\u2013inducible lysosomal thiol reductase (GILT), which facilitates disulfide bond\u2013containing Ag processing, was found to be upregulated in macrophages from Ncf1 mutant mice. Ncf1 mutant mice exhibited more severe G6PI peptide-induced arthritis, which was accompanied by the increased GILT expression in macrophages and enhanced Ag-specific T cell responses. Our results show that NOX2-dependent processing of the redox-sensitive autoantigens by APCs modify T cell activity and development of autoimmune arthritis.<\/jats:p>","DOI":"10.4049\/jimmunol.1700774","type":"journal-article","created":{"date-parts":[[2017,11,10]],"date-time":"2017-11-10T17:10:20Z","timestamp":1510333820000},"page":"3937-3942","source":"Crossref","is-referenced-by-count":29,"title":["Cutting Edge: Processing of Oxidized Peptides in Macrophages Regulates T Cell Activation and Development of Autoimmune Arthritis"],"prefix":"10.1093","volume":"199","author":[{"given":"Min","family":"Yang","sequence":"first","affiliation":[{"name":"Section for Medical Inflammation Research, Department of Medical Biochemistry and Biophysics, Karolinska Institute , 171 77 Stockholm,","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4922-0154","authenticated-orcid":false,"given":"Claus","family":"Haase","sequence":"additional","affiliation":[{"name":"Global Research, Novo Nordisk A\/S , 2880 Bagsvaerd,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johan","family":"Viljanen","sequence":"additional","affiliation":[{"name":"Department of Chemistry\u2013Biomedical Centre, Uppsala University , 751 23 Uppsala,","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5341-1722","authenticated-orcid":false,"given":"Bingze","family":"Xu","sequence":"additional","affiliation":[{"name":"Section for Medical Inflammation Research, Department of Medical Biochemistry and Biophysics, Karolinska Institute , 171 77 Stockholm,","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changrong","family":"Ge","sequence":"additional","affiliation":[{"name":"Section for Medical Inflammation Research, Department of Medical Biochemistry and Biophysics, Karolinska Institute , 171 77 Stockholm,","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Kihlberg","sequence":"additional","affiliation":[{"name":"Department of Chemistry\u2013Biomedical Centre, Uppsala University , 751 23 Uppsala,","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4969-2576","authenticated-orcid":false,"given":"Rikard","family":"Holmdahl","sequence":"additional","affiliation":[{"name":"Section for Medical Inflammation Research, Department of Medical Biochemistry and Biophysics, Karolinska Institute , 171 77 Stockholm,","place":["Sweden"]},{"name":"Center for Medical Immunopharmacology Research, Southern Medical University , 510515 Guangzhou,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2017,12,15]]},"reference":[{"key":"2025030614550524100_r1","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.1089\/ars.2012.4734","article-title":"Hydrogen peroxide as an immunological transmitter regulating autoreactive T cells","volume":"18","author":"Holmdahl","year":"2013","journal-title":"Antioxid. 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