{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T08:27:53Z","timestamp":1792225673926,"version":"4.4.0"},"reference-count":30,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2017,11,1]],"date-time":"2017-11-01T00:00:00Z","timestamp":1509494400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>mAbs that neutralize IL-17 or its receptor have proven efficacious in treating moderate-to-severe psoriasis, confirming IL-17 as an important driver of this disease. In mice, a rare population of T cells, \u03b3\u03b4T17 cells, appears to be a dominant source of IL-17 in experimental psoriasis. These cells traffic between lymph nodes and the skin, and are identified by their coexpression of the TCR variable regions \u03b34 and \u03b44. These cells are homologous to the V\u03b39V\u03b42 T cell population identified in human psoriatic plaques. In this study we report that a potent and specific small molecule antagonist of the CCR6 chemokine receptor, CCX2553, was efficacious in reducing multiple aspects of psoriasis in two different murine models of the disease. Administration of CCX2553 ameliorated skin inflammation in both the IL-23\u2013induced ear swelling model and the topical imiquimod model, and significantly reduced the number of \u03b3\u03b4T17 cells in inflamed skin. \u03b3\u03b4T17 cells were greatly reduced in imiquimod-treated skin of CCR6\u2212\/\u2212 mice, but adoptively transferred wild-type (CCR6+\/+) \u03b3\u03b4T17 cells homed normally to the skin of imiquimod-treated CCR6\u2212\/\u2212 mice. Our data suggest that \u03b3\u03b4T17 cells are completely dependent on CCR6 for homing to psoriasiform skin. Thus, CCR6 may constitute a novel target for a mechanistically distinct therapeutic approach to treating psoriasis.<\/jats:p>","DOI":"10.4049\/jimmunol.1700826","type":"journal-article","created":{"date-parts":[[2017,10,3]],"date-time":"2017-10-03T00:20:27Z","timestamp":1506990027000},"page":"3129-3136","source":"Crossref","is-referenced-by-count":52,"title":["IL-17\u2013Secreting \u03b3\u03b4 T Cells Are Completely Dependent upon CCR6 for Homing to Inflamed Skin"],"prefix":"10.1093","volume":"199","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4252-5182","authenticated-orcid":false,"given":"James J","family":"Campbell","sequence":"first","affiliation":[{"name":"ChemoCentryx Inc. , Mountain View, CA 94043"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8794-6947","authenticated-orcid":false,"given":"Karen","family":"Ebsworth","sequence":"additional","affiliation":[{"name":"ChemoCentryx Inc. , Mountain View, CA 94043"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda S","family":"Ertl","sequence":"additional","affiliation":[{"name":"ChemoCentryx Inc. , Mountain View, CA 94043"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey P","family":"McMahon","sequence":"additional","affiliation":[{"name":"ChemoCentryx Inc. , Mountain View, CA 94043"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dale","family":"Newland","sequence":"additional","affiliation":[{"name":"ChemoCentryx Inc. , Mountain View, CA 94043"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Wang","sequence":"additional","affiliation":[{"name":"ChemoCentryx Inc. , Mountain View, CA 94043"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shirley","family":"Liu","sequence":"additional","affiliation":[{"name":"ChemoCentryx Inc. , Mountain View, CA 94043"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenhua","family":"Miao","sequence":"additional","affiliation":[{"name":"ChemoCentryx Inc. , Mountain View, CA 94043"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0035-2746","authenticated-orcid":false,"given":"Ton","family":"Dang","sequence":"additional","affiliation":[{"name":"ChemoCentryx Inc. , Mountain View, CA 94043"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Penglie","family":"Zhang","sequence":"additional","affiliation":[{"name":"ChemoCentryx Inc. , Mountain View, CA 94043"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Israel F","family":"Charo","sequence":"additional","affiliation":[{"name":"ChemoCentryx Inc. , Mountain View, CA 94043"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajinder","family":"Singh","sequence":"additional","affiliation":[{"name":"ChemoCentryx Inc. , Mountain View, CA 94043"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas J","family":"Schall","sequence":"additional","affiliation":[{"name":"ChemoCentryx Inc. , Mountain View, CA 94043"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2017,11,1]]},"reference":[{"key":"2025030614511042100_r1","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1016\/S0140-6736(14)61909-7","article-title":"Psoriasis","volume":"386","author":"Boehncke","year":"2015","journal-title":"Lancet"},{"key":"2025030614511042100_r2","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1038\/jid.2009.59","article-title":"The IL-23\/Th17 axis in the immunopathogenesis of psoriasis","volume":"129","author":"Di Cesare","year":"2009","journal-title":"J. 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