{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T14:53:22Z","timestamp":1761490402214,"version":"3.38.0"},"reference-count":66,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,1,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>A link between inflammatory disease and bone loss is now recognized. However, limited data exist on the impact of virus infection on bone loss and regeneration. Bone loss results from an imbalance in remodeling, the physiological process whereby the skeleton undergoes continual cycles of formation and resorption. The specific molecular and cellular mechanisms linking virus-induced inflammation to bone loss remain unclear. In the current study, we provide evidence that infection of mice with either lymphocytic choriomeningitis virus (LCMV) or pneumonia virus of mice (PVM) resulted in rapid and substantial loss of osteoblasts from the bone surface. Osteoblast ablation was associated with elevated levels of circulating inflammatory cytokines, including TNF-\u03b1, IFN-\u03b3, IL-6, and CCL2. Both LCMV and PVM infections resulted in reduced osteoblast-specific gene expression in bone, loss of osteoblasts, and reduced serum markers of bone formation, including osteocalcin and procollagen type 1 N propeptide. Infection of Rag-1\u2013deficient mice (which lack adaptive immune cells) or specific depletion of CD8+ T lymphocytes limited osteoblast loss associated with LCMV infection. By contrast, CD8+ T cell depletion had no apparent impact on osteoblast ablation in association with PVM infection. In summary, our data demonstrate dramatic loss of osteoblasts in response to virus infection and associated systemic inflammation. Further, the inflammatory mechanisms mediating viral infection-induced bone loss depend on the specific inflammatory condition.<\/jats:p>","DOI":"10.4049\/jimmunol.1700927","type":"journal-article","created":{"date-parts":[[2017,12,6]],"date-time":"2017-12-06T18:15:22Z","timestamp":1512584122000},"page":"632-642","source":"Crossref","is-referenced-by-count":7,"title":["Osteoblasts Are Rapidly Ablated by Virus-Induced Systemic Inflammation following Lymphocytic Choriomeningitis Virus or Pneumonia Virus of Mice Infection in Mice"],"prefix":"10.1093","volume":"200","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1240-5964","authenticated-orcid":false,"given":"Steven","family":"Maltby","sequence":"first","affiliation":[{"name":"Priority Research Centre for Healthy Lungs, Department of Microbiology and Immunology, School of Biomedical Sciences and Pharmacy, Faculty of Health and Hunter Medical Research Institute, The University of Newcastle , Callaghan, New South Wales 2305,","place":["Australia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0962-7099","authenticated-orcid":false,"given":"Alyssa J","family":"Lochrin","sequence":"additional","affiliation":[{"name":"Priority Research Centre for Healthy Lungs, Department of Microbiology and Immunology, School of Biomedical Sciences and Pharmacy, Faculty of Health and Hunter Medical Research Institute, The University of Newcastle , Callaghan, New South Wales 2305,","place":["Australia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bianca","family":"Bartlett","sequence":"additional","affiliation":[{"name":"Priority Research Centre for Healthy Lungs, Department of Microbiology and Immunology, School of Biomedical Sciences and Pharmacy, Faculty of Health and Hunter Medical Research Institute, The University of Newcastle , Callaghan, New South Wales 2305,","place":["Australia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hock L","family":"Tay","sequence":"additional","affiliation":[{"name":"Priority Research Centre for Healthy Lungs, Department of Microbiology and Immunology, School of Biomedical Sciences and Pharmacy, Faculty of Health and Hunter Medical Research Institute, The University of Newcastle , Callaghan, New South Wales 2305,","place":["Australia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jessica","family":"Weaver","sequence":"additional","affiliation":[{"name":"Priority Research Centre for Healthy Lungs, Department of Microbiology and Immunology, School of Biomedical Sciences and Pharmacy, Faculty of Health and Hunter Medical Research Institute, The University of Newcastle , Callaghan, New South Wales 2305,","place":["Australia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ingrid J","family":"Poulton","sequence":"additional","affiliation":[{"name":"St. Vincent\u2019s Institute of Medical Research, The Department of Medicine, St Vincent\u2019s Hospital, University of Melbourne , Fitzroy, Victoria 3065,","place":["Australia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maximilian W","family":"Plank","sequence":"additional","affiliation":[{"name":"Priority Research Centre for Healthy Lungs, Department of Microbiology and Immunology, School of Biomedical Sciences and Pharmacy, Faculty of Health and Hunter Medical Research Institute, The University of Newcastle , Callaghan, New South Wales 2305,","place":["Australia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helene F","family":"Rosenberg","sequence":"additional","affiliation":[{"name":"Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health , Bethesda, MD 20892"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1421-8468","authenticated-orcid":false,"given":"Natalie A","family":"Sims","sequence":"additional","affiliation":[{"name":"St. Vincent\u2019s Institute of Medical Research, The Department of Medicine, St Vincent\u2019s Hospital, University of Melbourne , Fitzroy, Victoria 3065,","place":["Australia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul S","family":"Foster","sequence":"additional","affiliation":[{"name":"Priority Research Centre for Healthy Lungs, Department of Microbiology and Immunology, School of Biomedical Sciences and Pharmacy, Faculty of Health and Hunter Medical Research Institute, The University of Newcastle , Callaghan, New South Wales 2305,","place":["Australia"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2018,1,15]]},"reference":[{"key":"2025030610011494400_r1","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1128\/JVI.02034-14","article-title":"Bindarit, an inhibitor of monocyte chemotactic protein synthesis, protects against bone loss induced by chikungunya virus infection. 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