{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T07:18:21Z","timestamp":1791875901505,"version":"4.3.4"},"reference-count":106,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,1,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Sarcoplasmic\/endoplasmic reticulum Ca2+ adenosine triphosphatase (SERCA)2a, a critical regulator of calcium homeostasis, is known to be decreased in heart failure. Patients with myocarditis or dilated cardiomyopathy develop autoantibodies to SERCA2a suggesting that they may have pathogenetic significance. In this report, we describe epitope mapping analysis of SERCA2a in A\/J mice that leads us to make five observations: 1) SERCA2a contains multiple T cell epitopes that induce varying degrees of myocarditis. One epitope, SERCA2a 971\u2013990, induces widespread atrial inflammation without affecting noncardiac tissues; the cardiac abnormalities could be noninvasively captured by echocardiography, electrocardiography, and magnetic resonance microscopy imaging. 2) SERCA2a 971\u2013990-induced disease was associated with the induction of CD4 T cell responses and the epitope preferentially binds MHC class II\/IAk rather than IEk. By creating IAk\/and IEk\/SERCA2a 971\u2013990 dextramers, the T cell responses were determined by flow cytometry to be Ag specific. 3) SERCA2a 971\u2013990-sensitized T cells produce both Th1 and Th17 cytokines. 4) Animals immunized with SERCA2a 971\u2013990 showed Ag-specific Abs with enhanced production of IgG2a and IgG2b isotypes, suggesting that SERCA2a 971\u2013990 can potentially act as a common epitope for both T cells and B cells. 5) Finally, SERCA2a 971\u2013990-sensitized T cells were able to transfer disease to naive recipients. Together, these data indicate that SERCA2a is a critical autoantigen in the mediation of atrial inflammation in mice and that our model may be helpful to study the inflammatory events that underlie the development of conditions such as atrial fibrillation in humans.<\/jats:p>","DOI":"10.4049\/jimmunol.1701090","type":"journal-article","created":{"date-parts":[[2017,12,11]],"date-time":"2017-12-11T15:30:19Z","timestamp":1513006219000},"page":"523-537","source":"Crossref","is-referenced-by-count":16,"title":["Epitope Mapping of SERCA2a Identifies an Antigenic Determinant That Induces Mainly Atrial Myocarditis in A\/J Mice"],"prefix":"10.1093","volume":"200","author":[{"given":"Bharathi","family":"Krishnan","sequence":"first","affiliation":[{"name":"School of Veterinary Medicine and Biomedical Sciences, University of Nebraska-Lincoln , Lincoln, NE 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Chem."},{"key":"2025030610005748700_r9","doi-asserted-by":"crossref","first-page":"14483","DOI":"10.1016\/S0021-9258(19)49738-X","article-title":"Functional comparisons between isoforms of the sarcoplasmic or endoplasmic reticulum family of calcium pumps","volume":"267","author":"Lytton","year":"1992","journal-title":"J. Biol. Chem."},{"key":"2025030610005748700_r10","doi-asserted-by":"crossref","DOI":"10.5772\/48240","volume-title":"Calcium Cycling In Synthetic and Contractile Phasic or Tonic Vascular Smooth Muscle Cells.","author":"Lipskaia","year":"2012"},{"key":"2025030610005748700_r11","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1042\/bj3020559","article-title":"Regulation of splicing is responsible for the expression of the muscle-specific 2a isoform of the sarco\/endoplasmic-reticulum Ca(2+)-ATPase","volume":"302","author":"Van den Bosch","year":"1994","journal-title":"Biochem. J."},{"key":"2025030610005748700_r12","doi-asserted-by":"crossref","first-page":"2705","DOI":"10.1016\/j.bbamcr.2014.08.002","article-title":"Expression of sarco (endo) plasmic reticulum calcium ATPase (SERCA) system in normal mouse cardiovascular tissues, heart failure and atherosclerosis","volume":"1843","author":"Lipskaia","year":"2014","journal-title":"Biochim. Biophys. Acta"},{"key":"2025030610005748700_r13","doi-asserted-by":"crossref","first-page":"4670","DOI":"10.1016\/S0021-9258(19)39615-2","article-title":"Characterization of rabbit cardiac sarco(endo)plasmic reticulum Ca2(+)-ATPase gene","volume":"265","author":"Zarain-Herzberg","year":"1990","journal-title":"J. Biol. Chem."},{"key":"2025030610005748700_r14","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1038\/316696a0","article-title":"Amino-acid sequence of a Ca2+ + Mg2+-dependent ATPase from rabbit muscle sarcoplasmic reticulum, deduced from its complementary DNA sequence","volume":"316","author":"MacLennan","year":"1985","journal-title":"Nature"},{"key":"2025030610005748700_r15","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1006\/jmcc.1999.0962","article-title":"Expression of cardiac calcium regulatory proteins in atrium v ventricle in different species","volume":"31","author":"L\u00fcss","year":"1999","journal-title":"J. Mol. Cell. 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A possible mechanism for alterations in systolic and diastolic properties of the failing myocardium","volume":"72","author":"Arai","year":"1993","journal-title":"Circ. Res."},{"key":"2025030610005748700_r31","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1007\/BF00207509","article-title":"Sarcoplasmic reticulum Ca2+ATPase and phospholamban mRNA and protein levels in end-stage heart failure due to ischemic or dilated cardiomyopathy","volume":"74","author":"Flesch","year":"1996","journal-title":"J. Mol. Med. (Berl.)"},{"key":"2025030610005748700_r32","first-page":"767","article-title":"The function and significance of SERA2a in congestive heart failure: an analysis of gene therapy trials","volume":"32","author":"Wu","year":"2017","journal-title":"Histol. Histopathol."},{"key":"2025030610005748700_r33","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1093\/cvr\/cvp264","article-title":"Targeting calcium transport in ischaemic heart disease","volume":"84","author":"Talukder","year":"2009","journal-title":"Cardiovasc. Res."},{"key":"2025030610005748700_r34","doi-asserted-by":"crossref","first-page":"1929","DOI":"10.1006\/jmcc.1998.0748","article-title":"Contribution of abnormal sarcoplasmic reticulum ATPase activity to systolic and diastolic dysfunction in human heart failure","volume":"30","author":"Schmidt","year":"1998","journal-title":"J. Mol. Cell. Cardiol."},{"key":"2025030610005748700_r35","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.lfs.2015.09.022","article-title":"Bendavia restores mitochondrial energy metabolism gene expression and suppresses cardiac fibrosis in the border zone of the infarcted heart","volume":"141","author":"Shi","year":"2015","journal-title":"Life Sci."},{"key":"2025030610005748700_r36","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1007\/s11010-010-0508-4","article-title":"NADPH oxidase inhibition ameliorates cardiac dysfunction in rabbits with heart failure","volume":"343","author":"Liu","year":"2010","journal-title":"Mol. Cell. Biochem."},{"key":"2025030610005748700_r37","doi-asserted-by":"crossref","first-page":"38073","DOI":"10.1074\/jbc.M004804200","article-title":"Disruption of a single copy of the SERCA2 gene results in altered Ca2+ homeostasis and cardiomyocyte function","volume":"275","author":"Ji","year":"2000","journal-title":"J. Biol. Chem."},{"key":"2025030610005748700_r38","doi-asserted-by":"crossref","first-page":"2556","DOI":"10.1074\/jbc.274.4.2556","article-title":"Impaired cardiac performance in heterozygous mice with a null mutation in the sarco(endo)plasmic reticulum Ca2+-ATPase isoform 2 (SERCA2) gene","volume":"274","author":"Periasamy","year":"1999","journal-title":"J. Biol. Chem."},{"key":"2025030610005748700_r39","doi-asserted-by":"crossref","first-page":"H1146","DOI":"10.1152\/ajpheart.00720.2003","article-title":"Accelerated onset of heart failure in mice during pressure overload with chronically decreased SERCA2 calcium pump activity","volume":"286","author":"Schultz","year":"2004","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"2025030610005748700_r40","doi-asserted-by":"crossref","first-page":"2039","DOI":"10.1016\/j.bpj.2012.03.045","article-title":"Sodium accumulation in SERCA knockout-induced heart failure","volume":"102","author":"Li","year":"2012","journal-title":"Biophys. 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Invest."},{"issue":"Suppl. D","key":"2025030610005748700_r44","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1093\/eurheartj\/12.suppl_D.99","article-title":"The Ca-channel as cardiac autoantigen","volume":"12","author":"K\u00fchl","year":"1991","journal-title":"Eur. Heart J."},{"key":"2025030610005748700_r45","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1007\/978-3-642-73610-0_23","volume-title":"New Concepts in Viral Heart Disease.","author":"Morad","year":"1988"},{"key":"2025030610005748700_r46","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1161\/01.CIR.89.3.1217","article-title":"Cardiac sarcoplasmic reticulum calcium ATPase, an autoimmune antigen in experimental cardiomyopathy","volume":"89","author":"Sharaf","year":"1994","journal-title":"Circulation"},{"issue":"Suppl. O","key":"2025030610005748700_r47","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1093\/eurheartj\/16.suppl_O.92","article-title":"SR-Ca2+ ATPase as an autoimmunogen in experimental myocarditis","volume":"16","author":"Khaw","year":"1995","journal-title":"Eur. Heart J."},{"key":"2025030610005748700_r48","doi-asserted-by":"crossref","first-page":"2057","DOI":"10.1172\/JCI118642","article-title":"Identification of cardiac myosin peptides capable of inducing autoimmune myocarditis in BALB\/c mice","volume":"97","author":"Pummerer","year":"1996","journal-title":"J. Clin. Invest."},{"key":"2025030610005748700_r49","doi-asserted-by":"crossref","DOI":"10.1002\/iid3.177","article-title":"Branched chain \u03b1-ketoacid dehydrogenase kinase 111\u2013130, a T cell epitope that induces both autoimmune myocarditis and hepatitis in A\/J mice","volume-title":"Immun. Inflamm. 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Ther."},{"key":"2025030610005748700_r69","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.jim.2015.08.007","article-title":"Versatility of using major histocompatibility complex class II dextramers for derivation and characterization of antigen-specific, autoreactive T cell hybridomas","volume":"426","author":"Krishnan","year":"2015","journal-title":"J. Immunol. Methods"},{"key":"2025030610005748700_r70","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1111\/sji.12344","article-title":"Major histocompatibility complex class II dextramers: new tools for the detection of antigen-specific, CD4 T cells in basic and clinical research","volume":"82","author":"Massilamany","year":"2015","journal-title":"Scand. J. Immunol."},{"key":"2025030610005748700_r71","doi-asserted-by":"crossref","first-page":"14292","DOI":"10.1073\/pnas.1009234107","article-title":"Proinflammatory T helper type 17 cells are effective B-cell helpers","volume":"107","author":"Mitsdoerffer","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2025030610005748700_r72","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1038\/ncpcardio1301","article-title":"The cardiac sarcoplasmic\/endoplasmic reticulum calcium ATPase: a potent target for cardiovascular diseases","volume":"5","author":"Kawase","year":"2008","journal-title":"Nat. Clin. Pract. Cardiovasc. Med."},{"key":"2025030610005748700_r73","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1038\/35036035","article-title":"The versatility and universality of calcium signalling","volume":"1","author":"Berridge","year":"2000","journal-title":"Nat. Rev. Mol. 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Med."},{"key":"2025030610005748700_r77","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1038\/90935","article-title":"Autoimmune disease: why and where it occurs","volume":"7","author":"Marrack","year":"2001","journal-title":"Nat. Med."},{"key":"2025030610005748700_r78","doi-asserted-by":"crossref","first-page":"2498","DOI":"10.2174\/1381612821666150316123711","article-title":"Mouse models of autoimmune diseases - autoimmune myocarditis","volume":"21","author":"Muller","year":"2015","journal-title":"Curr. Pharm. Des."},{"key":"2025030610005748700_r79","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1097\/BOR.0b013e3283620036","article-title":"Autoimmunity in viral myocarditis","volume":"25","author":"Reddy","year":"2013","journal-title":"Curr. Opin. Rheumatol."},{"key":"2025030610005748700_r80","doi-asserted-by":"crossref","first-page":"1318","DOI":"10.1161\/01.CIR.89.3.1318","article-title":"Autoimmunity and the pathogenesis of myocarditis","volume":"89","author":"Yeh","year":"1994","journal-title":"Circulation"},{"key":"2025030610005748700_r81","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1161\/CIRCULATIONAHA.113.005119","article-title":"Worldwide epidemiology of atrial fibrillation: a global Burden of disease 2010 study","volume":"129","author":"Chugh","year":"2013","journal-title":"Circulation"},{"key":"2025030610005748700_r82","doi-asserted-by":"crossref","first-page":"2263","DOI":"10.1016\/j.jacc.2012.04.063","article-title":"Inflammation in atrial fibrillation","volume":"60","author":"Guo","year":"2012","journal-title":"J. Am. Coll. Cardiol."},{"key":"2025030610005748700_r83","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1016\/j.jacc.2015.06.1313","article-title":"Cardiac fibrosis in patients with atrial fibrillation: mechanisms and clinical implications","volume":"66","author":"Dzeshka","year":"2015","journal-title":"J. Am. Coll. Cardiol."},{"key":"2025030610005748700_r84","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1038\/nrcardio.2015.2","article-title":"Inflammation and the pathogenesis of atrial fibrillation","volume":"12","author":"Hu","year":"2015","journal-title":"Nat. Rev. Cardiol."},{"key":"2025030610005748700_r85","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1253\/circj.CJ-15-0138","article-title":"Role of inflammation in atrial fibrillation pathophysiology and management","volume":"79","author":"Harada","year":"2015","journal-title":"Circ. J."},{"key":"2025030610005748700_r86","doi-asserted-by":"crossref","first-page":"1441","DOI":"10.1084\/jem.192.10.1441","article-title":"Mast cells control neutrophil recruitment during T cell-mediated delayed-type hypersensitivity reactions through tumor necrosis factor and macrophage inflammatory protein 2","volume":"192","author":"Biedermann","year":"2000","journal-title":"J. Exp. Med."},{"key":"2025030610005748700_r87","doi-asserted-by":"crossref","first-page":"1573","DOI":"10.4049\/jimmunol.121.4.1573","article-title":"Regulation of delayed-type hypersensitivity reactions by cyclophosphamide-sensitive T cells","volume":"121","author":"Schwartz","year":"1978","journal-title":"J. Immunol."},{"key":"2025030610005748700_r88","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1038\/nm1097-1133","article-title":"Persistent infection with Theiler\u2019s virus leads to CNS autoimmunity via epitope spreading","volume":"3","author":"Miller","year":"1997","journal-title":"Nat. Med."},{"key":"2025030610005748700_r89","doi-asserted-by":"crossref","first-page":"3987","DOI":"10.4049\/jimmunol.1101202","article-title":"Myeloma-induced alloreactive T cells arising in myeloma-infiltrated bones include double-positive CD8+CD4+ T cells: evidence from myeloma-bearing mouse model","volume":"187","author":"Freeman","year":"2011","journal-title":"J. Immunol."},{"key":"2025030610005748700_r90","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1084\/jem.191.5.761","article-title":"High frequency of autoreactive myelin proteolipid protein-specific T cells in the periphery of naive mice: mechanisms of selection of the self-reactive repertoire","volume":"191","author":"Anderson","year":"2000","journal-title":"J. Exp. Med."},{"key":"2025030610005748700_r91","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.tcm.2012.07.005","article-title":"Role of impaired central tolerance to \u03b1-myosin in inflammatory heart disease","volume":"22","author":"Lv","year":"2012","journal-title":"Trends Cardiovasc. Med."},{"key":"2025030610005748700_r92","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1080\/08916930500484799","article-title":"Multiple sclerosis and virus induced immune responses: autoimmunity can be primed by molecular mimicry and augmented by bystander activation","volume":"39","author":"McCoy","year":"2006","journal-title":"Autoimmunity"},{"key":"2025030610005748700_r93","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/S0065-2776(08)00604-4","article-title":"Pathogenesis of myocarditis and dilated cardiomyopathy","volume":"99","author":"Cihakova","year":"2008","journal-title":"Adv. Immunol."},{"key":"2025030610005748700_r94","doi-asserted-by":"crossref","first-page":"2311","DOI":"10.1002\/eji.201142209","article-title":"Cooperation of Th1 and Th17 cells determines transition from autoimmune myocarditis to dilated cardiomyopathy","volume":"42","author":"Nindl","year":"2012","journal-title":"Eur. J. Immunol."},{"key":"2025030610005748700_r95","doi-asserted-by":"crossref","first-page":"pii:e85851","DOI":"10.1172\/jci.insight.85851","article-title":"Cardiac myosin-Th17 responses promote heart failure in human myocarditis","volume":"1","author":"Myers","year":"2016","journal-title":"JCI Insight"},{"key":"2025030610005748700_r96","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/S0002-9440(10)61665-3","article-title":"Cardiac myosin and the TH1\/TH2 paradigm in autoimmune myocarditis","volume":"159","author":"Cunningham","year":"2001","journal-title":"Am. J. Pathol."},{"key":"2025030610005748700_r97","doi-asserted-by":"crossref","first-page":"1646","DOI":"10.1161\/CIRCRESAHA.109.213157","article-title":"Interleukin-17A is dispensable for myocarditis but essential for the progression to dilated cardiomyopathy","volume":"106","author":"Baldeviano","year":"2010","journal-title":"Circ. Res."},{"key":"2025030610005748700_r98","doi-asserted-by":"crossref","first-page":"4175","DOI":"10.4049\/jimmunol.163.8.4175","article-title":"Integrating signals from IFN-\u03b3 and IL-4 by B cells: positive and negative effects on CD40 ligand-induced proliferation, survival, and division-linked isotype switching to IgG1, IgE, and IgG2a","volume":"163","author":"Hasbold","year":"1999","journal-title":"J. Immunol."},{"key":"2025030610005748700_r99","doi-asserted-by":"crossref","first-page":"9131","DOI":"10.1073\/pnas.89.19.9131","article-title":"Expression of myosin-class II major histocompatibility complexes in the normal myocardium occurs before induction of autoimmune myocarditis","volume":"89","author":"Smith","year":"1992","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2025030610005748700_r100","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1161\/01.RES.70.4.856","article-title":"Neutralization of endogenous tumor necrosis factor ameliorates the severity of myosin-induced myocarditis","volume":"70","author":"Smith","year":"1992","journal-title":"Circ. Res."},{"key":"2025030610005748700_r101","first-page":"337","article-title":"Abnormal expression of histocompatibility and mitochondrial antigens by cardiac tissue from patients with myocarditis and dilated cardiomyopathy","volume":"139","author":"Ansari","year":"1991","journal-title":"Am. J. 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