{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T23:08:06Z","timestamp":1792710486969,"version":"4.5.0"},"reference-count":56,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Understanding the control of Ag restimulation-induced T cell death (RICD), especially in cancer immunotherapy, where highly proliferating T cells will encounter potentially large amounts of tumor Ags, is important now more than ever. It has been known that growth cytokines make T cells susceptible to RICD, but the precise molecular mediators that govern this in T cell subsets is unknown until now. STAT proteins are a family of transcription factors that regulate gene expression programs underlying key immunological processes. In particular, STAT5 is known to favor the generation and survival of memory T cells. In this study, we report an unexpected role for STAT5 signaling in the death of effector memory T (TEM) cells in mice and humans. TEM cell death was prevented with neutralizing anti\u2013IL-2 Ab or STAT5\/JAK3 inhibitors, indicating that STAT5 signaling drives RICD in TEM cells. Moreover, we identified a unique patient with a heterozygous missense mutation in the coiled-coil domain of STAT5B that presented with autoimmune lymphoproliferative syndrome\u2013like features. Similar to Stat5b\u2212\/\u2212 mice, this patient exhibited increased CD4+ TEM cells in the peripheral blood. The mutant STAT5B protein dominantly interfered with STAT5-driven transcriptional activity, leading to global downregulation of STAT5-regulated genes in patient T cells upon IL-2 stimulation. Notably, CD4+ TEM cells from the patient were strikingly resistant to cell death by in vitro TCR restimulation, a finding that was recapitulated in Stat5b\u2212\/\u2212 mice. Hence, STAT5B is a crucial regulator of RICD in memory T cells in mice and humans.<\/jats:p>","DOI":"10.4049\/jimmunol.1701133","type":"journal-article","created":{"date-parts":[[2017,11,29]],"date-time":"2017-11-29T16:52:32Z","timestamp":1511974352000},"page":"110-118","source":"Crossref","is-referenced-by-count":37,"title":["STAT5B: A Differential Regulator of the Life and Death of CD4+ Effector Memory T Cells"],"prefix":"10.1093","volume":"200","author":[{"given":"Sonia S","family":"Majri","sequence":"first","affiliation":[{"name":"Molecular Development of the Immune System Section, Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health , Bethesda, MD 20892"},{"name":"Ecole Doctorale H\u00e9matologie-Oncogen\u00e8se-Bioth\u00e9rapies, Universit\u00e8 Paris-Diderot , Paris, 75475","place":["France"]},{"name":"National Institute of Allergy and Infectious Diseases Clinical Genomics Program, National Institutes of Health , Bethesda, MD 20892"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6626-7371","authenticated-orcid":false,"given":"Jill M","family":"Fritz","sequence":"additional","affiliation":[{"name":"Molecular Development of the Immune System Section, Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health , Bethesda, MD 20892"},{"name":"National Institute of Allergy and Infectious Diseases Clinical Genomics Program, National Institutes of Health , Bethesda, MD 20892"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8068-2176","authenticated-orcid":false,"given":"Alejandro V","family":"Villarino","sequence":"additional","affiliation":[{"name":"Molecular Immunology and Inflammation Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health , Bethesda, MD 20892"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8838-8665","authenticated-orcid":false,"given":"Lixin","family":"Zheng","sequence":"additional","affiliation":[{"name":"Molecular Development of the Immune System Section, Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health , Bethesda, MD 20892"},{"name":"National Institute of Allergy and Infectious Diseases Clinical Genomics Program, National Institutes of Health , Bethesda, MD 20892"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chrysi","family":"Kanellopoulou","sequence":"additional","affiliation":[{"name":"Molecular Development of the Immune System Section, Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health , Bethesda, MD 20892"},{"name":"National Institute of Allergy and Infectious Diseases Clinical Genomics Program, National Institutes of Health , Bethesda, MD 20892"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4423-5402","authenticated-orcid":false,"given":"Benjamin","family":"Chaigne-Delalande","sequence":"additional","affiliation":[{"name":"Molecular Development of the Immune System Section, Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health , Bethesda, MD 20892"},{"name":"National Institute of Allergy and Infectious Diseases Clinical Genomics Program, National Institutes of Health , Bethesda, MD 20892"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juha","family":"Gr\u00f6nholm","sequence":"additional","affiliation":[{"name":"Molecular Development of the Immune System Section, Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health , Bethesda, MD 20892"},{"name":"National Institute of Allergy and Infectious Diseases Clinical Genomics Program, National Institutes of Health , Bethesda, MD 20892"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie E","family":"Niemela","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Clinical Center, National Institutes of Health , Bethesda, MD 20892"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2968-1156","authenticated-orcid":false,"given":"Behdad","family":"Afzali","sequence":"additional","affiliation":[{"name":"Molecular Immunology and Inflammation Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health , Bethesda, MD 20892"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1078-1838","authenticated-orcid":false,"given":"Matthew","family":"Biancalana","sequence":"additional","affiliation":[{"name":"Molecular Development of the Immune System Section, Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health , Bethesda, MD 20892"},{"name":"National Institute of Allergy and Infectious Diseases Clinical Genomics Program, National Institutes of Health , Bethesda, MD 20892"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefania","family":"Pittaluga","sequence":"additional","affiliation":[{"name":"Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, National Institutes of Health , Bethesda, MD 20892"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3216-810X","authenticated-orcid":false,"given":"Ashleigh","family":"Sun","sequence":"additional","affiliation":[{"name":"Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health , Bethesda, MD 20892"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 L","family":"Cohen","sequence":"additional","affiliation":[{"name":"Institut Mondor de Recherche Biom\u00e9dicale, INSERM U955 , Cr\u00e9teil, 94000","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3207-5464","authenticated-orcid":false,"given":"Steven M","family":"Holland","sequence":"additional","affiliation":[{"name":"National Institute of Allergy and Infectious Diseases Clinical Genomics Program, National Institutes of Health , Bethesda, MD 20892"},{"name":"Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health , Bethesda, MD 20892"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6456-9752","authenticated-orcid":false,"given":"John J","family":"O\u2019Shea","sequence":"additional","affiliation":[{"name":"Molecular Immunology and Inflammation Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health , Bethesda, MD 20892"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gulbu","family":"Uzel","sequence":"additional","affiliation":[{"name":"National Institute of Allergy and Infectious Diseases Clinical Genomics Program, National Institutes of Health , Bethesda, MD 20892"},{"name":"Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health , Bethesda, MD 20892"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J","family":"Lenardo","sequence":"additional","affiliation":[{"name":"Molecular Development of the Immune System Section, Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health , Bethesda, MD 20892"},{"name":"National Institute of Allergy and Infectious Diseases Clinical Genomics Program, National Institutes of Health , Bethesda, MD 20892"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2018,1,1]]},"reference":[{"key":"2025030610003044700_r1","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.ctrv.2016.02.001","article-title":"Management of toxicities of immune checkpoint inhibitors","volume":"44","author":"Spain","year":"2016","journal-title":"Cancer Treat. Rev."},{"key":"2025030610003044700_r2","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1046\/j.1365-2567.2002.01379.x","article-title":"Fas ligand and the fate of antitumour cytotoxic T lymphocytes","volume":"105","author":"O\u2019Connell","year":"2002","journal-title":"Immunology"},{"issue":"2, Suppl","key":"2025030610003044700_r3","doi-asserted-by":"crossref","first-page":"S121","DOI":"10.1016\/S0092-8674(02)00701-8","article-title":"Cytokine signaling in 2002: new surprises in the Jak\/Stat pathway","volume":"109","author":"O\u2019Shea","year":"2002","journal-title":"Cell"},{"key":"2025030610003044700_r4","doi-asserted-by":"crossref","first-page":"1630","DOI":"10.1126\/science.277.5332.1630","article-title":"STATs and gene regulation","volume":"277","author":"Darnell","year":"1997","journal-title":"Science"},{"key":"2025030610003044700_r5","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1038\/nri2958","article-title":"Genomic views of STAT function in CD4+ T helper cell differentiation","volume":"11","author":"O\u2019Shea","year":"2011","journal-title":"Nat. Rev. Immunol."},{"key":"2025030610003044700_r6","doi-asserted-by":"crossref","first-page":"21","DOI":"10.4049\/jimmunol.1401867","article-title":"Mechanisms of Jak\/STAT signaling in immunity and disease","volume":"194","author":"Villarino","year":"2015","journal-title":"J. Immunol."},{"key":"2025030610003044700_r7","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/S1359-6101(99)00011-8","article-title":"Stat5a and Stat5b: fraternal twins of signal transduction and transcriptional activation","volume":"10","author":"Grimley","year":"1999","journal-title":"Cytokine Growth Factor Rev."},{"key":"2025030610003044700_r8","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1038\/nrm909","article-title":"Stats: transcriptional control and biological impact","volume":"3","author":"Levy","year":"2002","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"2025030610003044700_r9","doi-asserted-by":"crossref","first-page":"8831","DOI":"10.1073\/pnas.92.19.8831","article-title":"Cloning and expression of Stat5 and an additional homologue (Stat5b) involved in prolactin signal transduction in mouse mammary tissue","volume":"92","author":"Liu","year":"1995","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2025030610003044700_r10","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1073\/pnas.0507350103","article-title":"Stat5a\/b are essential for normal lymphoid development and differentiation","volume":"103","author":"Yao","year":"2006","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2025030610003044700_r11","doi-asserted-by":"crossref","first-page":"8037","DOI":"10.1128\/MCB.24.18.8037-8047.2004","article-title":"Inactivation of Stat5 in mouse mammary epithelium during pregnancy reveals distinct functions in cell proliferation, survival, and differentiation","volume":"24","author":"Cui","year":"2004","journal-title":"Mol. Cell. Biol."},{"key":"2025030610003044700_r12","doi-asserted-by":"crossref","first-page":"e1584","DOI":"10.1542\/peds.2005-2882","article-title":"Characterization of immunodeficiency in a patient with growth hormone insensitivity secondary to a novel STAT5b gene mutation","volume":"118","author":"Bernasconi","year":"2006","journal-title":"Pediatrics"},{"key":"2025030610003044700_r13","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.beem.2010.09.003","article-title":"STAT5b deficiency: lessons from STAT5b gene mutations","volume":"25","author":"Hwa","year":"2011","journal-title":"Best Pract. Res. Clin. Endocrinol. Metab."},{"key":"2025030610003044700_r14","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1056\/NEJMoa022926","article-title":"Growth hormone insensitivity associated with a STAT5b mutation","volume":"349","author":"Kofoed","year":"2003","journal-title":"N. Engl. J. Med."},{"key":"2025030610003044700_r15","doi-asserted-by":"crossref","first-page":"2770","DOI":"10.4049\/jimmunol.177.5.2770","article-title":"Cutting edge: decreased accumulation and regulatory function of CD4+ CD25(high) T cells in human STAT5b deficiency","volume":"177","author":"Cohen","year":"2006","journal-title":"J. Immunol."},{"key":"2025030610003044700_r16","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.immuni.2013.01.004","article-title":"Interleukin-2 at the crossroads of effector responses, tolerance, and immunotherapy","volume":"38","author":"Liao","year":"2013","journal-title":"Immunity"},{"key":"2025030610003044700_r17","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1146\/annurev.immunol.24.021605.090727","article-title":"Diverse functions of IL-2, IL-15, and IL-7 in lymphoid homeostasis","volume":"24","author":"Ma","year":"2006","journal-title":"Annu. Rev. Immunol."},{"key":"2025030610003044700_r18","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1038\/353858a0","article-title":"Interleukin-2 programs mouse alpha beta T lymphocytes for apoptosis","volume":"353","author":"Lenardo","year":"1991","journal-title":"Nature"},{"key":"2025030610003044700_r19","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1111\/j.1600-065X.2010.00917.x","article-title":"The power and the promise of restimulation-induced cell death in human immune diseases","volume":"236","author":"Snow","year":"2010","journal-title":"Immunol. Rev."},{"key":"2025030610003044700_r20","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1038\/nri778","article-title":"Effector and memory T-cell differentiation: implications for vaccine development","volume":"2","author":"Kaech","year":"2002","journal-title":"Nat. Rev. Immunol."},{"key":"2025030610003044700_r21","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1016\/j.immuni.2008.11.002","article-title":"Homeostasis of naive and memory T cells","volume":"29","author":"Surh","year":"2008","journal-title":"Immunity"},{"key":"2025030610003044700_r22","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1038\/cdd.2010.155","article-title":"Specific elimination of effector memory CD4+ T cells due to enhanced Fas signaling complex formation and association with lipid raft microdomains","volume":"18","author":"Ramaswamy","year":"2011","journal-title":"Cell Death Differ."},{"key":"2025030610003044700_r23","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1038\/ng.806","article-title":"A framework for variation discovery and genotyping using next-generation DNA sequencing data","volume":"43","author":"DePristo","year":"2011","journal-title":"Nat. Genet."},{"key":"2025030610003044700_r24","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1101\/gr.107524.110","article-title":"The genome analysis toolkit: a MapReduce framework for analyzing next-generation DNA sequencing data","volume":"20","author":"McKenna","year":"2010","journal-title":"Genome Res."},{"key":"2025030610003044700_r25","doi-asserted-by":"crossref","first-page":"e164","DOI":"10.1093\/nar\/gkq603","article-title":"ANNOVAR: functional annotation of genetic variants from high-throughput sequencing data","volume":"38","author":"Wang","year":"2010","journal-title":"Nucleic Acids Res."},{"key":"2025030610003044700_r26","doi-asserted-by":"crossref","first-page":"e3874","DOI":"10.1371\/journal.pone.0003874","article-title":"GeneDistiller--distilling candidate genes from linkage intervals","volume":"3","author":"Seelow","year":"2008","journal-title":"PLoS One"},{"key":"2025030610003044700_r27","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1038\/nprot.2008.211","article-title":"Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources","volume":"4","author":"Huang","year":"2009","journal-title":"Nat. Protoc."},{"key":"2025030610003044700_r28","doi-asserted-by":"crossref","first-page":"40782","DOI":"10.1074\/jbc.M507682200","article-title":"Structure of the unphosphorylated STAT5a dimer","volume":"280","author":"Neculai","year":"2005","journal-title":"J. Biol. Chem."},{"key":"2025030610003044700_r29","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1016\/S0092-8674(00)81443-9","article-title":"Crystal structure of a tyrosine phosphorylated STAT-1 dimer bound to DNA","volume":"93","author":"Chen","year":"1998","journal-title":"Cell"},{"key":"2025030610003044700_r30","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.1126\/science.279.5353.1048","article-title":"Structure of the amino-terminal protein interaction domain of STAT-4","volume":"279","author":"Vinkemeier","year":"1998","journal-title":"Science"},{"key":"2025030610003044700_r31","doi-asserted-by":"crossref","first-page":"1910","DOI":"10.1128\/MCB.19.3.1910","article-title":"The significance of tetramerization in promoter recruitment by Stat5","volume":"19","author":"John","year":"1999","journal-title":"Mol. Cell. Biol."},{"key":"2025030610003044700_r32","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1038\/nprot.2012.016","article-title":"Differential gene and transcript expression analysis of RNA-seq experiments with TopHat and Cufflinks","volume":"7","author":"Trapnell","year":"2012","journal-title":"Nat. Protoc."},{"key":"2025030610003044700_r33","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1093\/bioinformatics\/btp616","article-title":"edgeR: a Bioconductor package for differential expression analysis of digital gene expression data","volume":"26","author":"Robinson","year":"2010","journal-title":"Bioinformatics"},{"key":"2025030610003044700_r34","doi-asserted-by":"crossref","first-page":"15545","DOI":"10.1073\/pnas.0506580102","article-title":"Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles","volume":"102","author":"Subramanian","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2025030610003044700_r35","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1093\/bioinformatics\/btt703","article-title":"Causal analysis approaches in ingenuity pathway analysis","volume":"30","author":"Kr\u00e4mer","year":"2014","journal-title":"Bioinformatics"},{"key":"2025030610003044700_r36","doi-asserted-by":"crossref","first-page":"16601","DOI":"10.1073\/pnas.1003457107","article-title":"Differential effects of STAT5 and PI3K\/AKT signaling on effector and memory CD8 T-cell survival","volume":"107","author":"Hand","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2025030610003044700_r37","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1172\/JCI39748","article-title":"CD81 gene defect in humans disrupts CD19 complex formation and leads to antibody deficiency","volume":"120","author":"van Zelm","year":"2010","journal-title":"J. Clin. Invest."},{"key":"2025030610003044700_r38","doi-asserted-by":"crossref","first-page":"2566","DOI":"10.1038\/sj.onc.1203523","article-title":"The role of Stat5a and Stat5b in signaling by IL-2 family cytokines","volume":"19","author":"Lin","year":"2000","journal-title":"Oncogene"},{"key":"2025030610003044700_r39","doi-asserted-by":"crossref","first-page":"3069","DOI":"10.4049\/jimmunol.1601532","article-title":"Dimethyl fumarate selectively reduces memory T cells and shifts the balance between Th1\/Th17 and Th2 in multiple sclerosis patients","volume":"198","author":"Wu","year":"2017","journal-title":"J. Immunol."},{"key":"2025030610003044700_r40","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1016\/j.immuni.2013.08.031","article-title":"Human circulating PD-1+CXCR3-CXCR5+ memory Tfh cells are highly functional and correlate with broadly neutralizing HIV antibody responses","volume":"39","author":"Locci","year":"2013","journal-title":"Immunity"},{"key":"2025030610003044700_r41","doi-asserted-by":"crossref","first-page":"1635","DOI":"10.1084\/jem.20110958","article-title":"Gain-of-function human STAT1 mutations impair IL-17 immunity and underlie chronic mucocutaneous candidiasis","volume":"208","author":"Liu","year":"2011","journal-title":"J. Exp. Med."},{"key":"2025030610003044700_r42","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1146\/annurev.immunol.17.1.221","article-title":"Mature T lymphocyte apoptosis--immune regulation in a dynamic and unpredictable antigenic environment","volume":"17","author":"Lenardo","year":"1999","journal-title":"Annu. Rev. Immunol."},{"key":"2025030610003044700_r43","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1172\/JCI0215617","article-title":"Stat proteins and oncogenesis","volume":"109","author":"Bromberg","year":"2002","journal-title":"J. Clin. Invest."},{"key":"2025030610003044700_r44","doi-asserted-by":"crossref","first-page":"210","DOI":"10.4049\/jimmunol.170.1.210","article-title":"A role for Stat5 in CD8+ T cell homeostasis","volume":"170","author":"Kelly","year":"2003","journal-title":"J. Immunol."},{"key":"2025030610003044700_r45","doi-asserted-by":"crossref","first-page":"2638","DOI":"10.1038\/sj.onc.1203522","article-title":"Modulation of STAT signaling by STAT-interacting proteins","volume":"19","author":"Shuai","year":"2000","journal-title":"Oncogene"},{"key":"2025030610003044700_r46","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/S0092-8674(00)80965-4","article-title":"Functional association of Nmi with Stat5 and Stat1 in IL-2- and IFNgamma-mediated signaling","volume":"96","author":"Zhu","year":"1999","journal-title":"Cell"},{"key":"2025030610003044700_r47","doi-asserted-by":"crossref","first-page":"6836","DOI":"10.1093\/emboj\/20.23.6836","article-title":"Functional interaction of STAT5 and nuclear receptor co-repressor SMRT: implications in negative regulation of STAT5-dependent transcription","volume":"20","author":"Nakajima","year":"2001","journal-title":"EMBO J."},{"key":"2025030610003044700_r48","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1016\/j.immuni.2013.09.007","article-title":"Circulating precursor CCR7(lo)PD-1(hi) CXCR5+ CD4+ T cells indicate Tfh cell activity and promote antibody responses upon antigen reexposure","volume":"39","author":"He","year":"2013","journal-title":"Immunity"},{"key":"2025030610003044700_r49","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1084\/jem.20111174","article-title":"STAT5 is a potent negative regulator of TFH cell differentiation","volume":"209","author":"Johnston","year":"2012","journal-title":"J. Exp. Med."},{"key":"2025030610003044700_r50","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1038\/sj.onc.1209775","article-title":"STAT5 represses BCL6 expression by binding to a regulatory region frequently mutated in lymphomas","volume":"26","author":"Walker","year":"2007","journal-title":"Oncogene"},{"key":"2025030610003044700_r51","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.4049\/jimmunol.179.2.1068","article-title":"Stat5 is essential for early B cell development but not for B cell maturation and function","volume":"179","author":"Dai","year":"2007","journal-title":"J. Immunol."},{"key":"2025030610003044700_r52","doi-asserted-by":"crossref","first-page":"e08384","DOI":"10.7554\/eLife.08384","article-title":"Signal transducer and activator of transcription 5 (STAT5) paralog dose governs T cell effector and regulatory functions","volume":"5","author":"Villarino","year":"2016","journal-title":"eLife"},{"key":"2025030610003044700_r53","doi-asserted-by":"crossref","first-page":"4721","DOI":"10.1182\/blood-2009-04-216390","article-title":"The transcription factors STAT5A\/B regulate GM-CSF-mediated granulopoiesis","volume":"114","author":"Kimura","year":"2009","journal-title":"Blood"},{"key":"2025030610003044700_r54","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1038\/nrg3241","article-title":"De novo mutations in human genetic disease","volume":"13","author":"Veltman","year":"2012","journal-title":"Nat. Rev. Genet."},{"key":"2025030610003044700_r55","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1111\/j.1365-2567.2010.03260.x","article-title":"Memory CD4 T cells: generation, reactivation and re-assignment","volume":"130","author":"MacLeod","year":"2010","journal-title":"Immunology"},{"key":"2025030610003044700_r56","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1016\/S0952-7915(02)00338-2","article-title":"Homeostasis of na\u00efve, effector and memory CD8 T cells","volume":"14","author":"Tuma","year":"2002","journal-title":"Curr. Opin. Immunol."}],"container-title":["The Journal of Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/200\/1\/110\/61512469\/ji1701133.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/200\/1\/110\/61512469\/ji1701133.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,6]],"date-time":"2025-03-06T10:01:34Z","timestamp":1741255294000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jimmunol\/article\/200\/1\/110\/7962220"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1,1]]},"references-count":56,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,1,1]]}},"URL":"https:\/\/doi.org\/10.4049\/jimmunol.1701133","relation":{},"ISSN":["0022-1767","1550-6606"],"issn-type":[{"value":"0022-1767","type":"print"},{"value":"1550-6606","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2018,1]]},"published":{"date-parts":[[2018,1,1]]}}}