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Ly6C expression has been used to distinguish short-lived effector CD4+ T cells from memory precursor effector cells, whereas Sca-1 has been used in the identification of CD8+ memory stem cells. This study examines the expression patterns of these molecules and establishes that, in vitro, IL-27, type I IFN, and IFN-\u03b3 are potent inducers of Ly6C and Sca-1 in naive mouse CD4+ and CD8+ T cells, whereas TGF-\u03b2 limits their expression. The induction of Ly6C and Sca-1 by IL-27 and IFN-\u03b3 is dependent on STAT1, but not STAT3 or T-bet. In mouse splenocytes, at homeostasis, Ly6C and Sca-1 expression was not restricted to effector cells, but was also found at various levels on naive and memory populations. However, in response to infection with Toxoplasma gondii, pathogen-specific T cells expressed high levels of these molecules and in this context, endogenous IL-27 and IFN-\u03b3 were required for the expression of Ly6C but not Sca-1. Together, these findings highlight the TCR-dependent and cytokine-mediated signals that modulate T cell expression of Ly6C and Sca-1 in vitro and in vivo during infection.<\/jats:p>","DOI":"10.4049\/jimmunol.1701154","type":"journal-article","created":{"date-parts":[[2018,1,22]],"date-time":"2018-01-22T18:50:22Z","timestamp":1516647022000},"page":"1761-1770","source":"Crossref","is-referenced-by-count":73,"title":["Cytokine- and TCR-Mediated Regulation of T Cell Expression of Ly6C and Sca-1"],"prefix":"10.1093","volume":"200","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2032-8228","authenticated-orcid":false,"given":"Jonathan H","family":"DeLong","sequence":"first","affiliation":[{"name":"Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania , Philadelphia, PA 19104"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aisling O\u2019Hara","family":"Hall","sequence":"additional","affiliation":[{"name":"Immunology Discovery Research, Janssen Research and Development, LLC , Spring House, PA 19002"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Konradt","sequence":"additional","affiliation":[{"name":"Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania , Philadelphia, PA 19104"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaia M","family":"Coppock","sequence":"additional","affiliation":[{"name":"Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania , Philadelphia, PA 19104"},{"name":"Department of Nephrology, University of Pennsylvania , Philadelphia, PA 19104"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeongho","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania , Philadelphia, PA 19104"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gretchen","family":"Harms Pritchard","sequence":"additional","affiliation":[{"name":"Department of Immunology, University of Washington , Seattle, WA 98109"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher A","family":"Hunter","sequence":"additional","affiliation":[{"name":"Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania , Philadelphia, PA 19104"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2018,3,1]]},"reference":[{"key":"2025030610051898900_r1","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.4049\/jimmunol.180.3.1309","article-title":"Effector CD8 T cell development: a balancing act between memory cell potential and terminal differentiation","volume":"180","author":"Joshi","year":"2008","journal-title":"J. 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