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To understand the mechanisms supporting T cell recruitment to the salivary gland, we compared T cell migration to the salivary gland in mice that were infected or not with murine CMV (MCMV), a herpesvirus that infects the salivary gland and promotes the accumulation of salivary gland tissue-resident memory T cells. We found that acute MCMV infection increased rapid T cell recruitment to the salivary gland but that equal numbers of activated CD8+ T cells eventually accumulated in infected and uninfected glands. T cell recruitment to uninfected salivary glands depended on chemokines and the integrin \u03b14. Several chemokines were expressed in the salivary glands of infected and uninfected mice, and many of these could promote the migration of MCMV-specific T cells in vitro. MCMV infection increased the expression of chemokines that interact with the receptors CXCR3 and CCR5, but neither receptor was needed for T cell recruitment to the salivary gland during MCMV infection. Unexpectedly, however, the chemokine receptor CXCR3 was critical for T cell accumulation in uninfected salivary glands. Together, these data suggest that CXCR3 and the integrin \u03b14 mediate T cell recruitment to uninfected salivary glands but that redundant mechanisms mediate T cell recruitment after MCMV infection.<\/jats:p>","DOI":"10.4049\/jimmunol.1701272","type":"journal-article","created":{"date-parts":[[2017,12,29]],"date-time":"2017-12-29T15:10:18Z","timestamp":1514560218000},"page":"1133-1145","source":"Crossref","is-referenced-by-count":33,"title":["The Chemokine Receptor CXCR3 Promotes CD8+ T Cell Accumulation in Uninfected Salivary Glands but Is Not Necessary after Murine Cytomegalovirus Infection"],"prefix":"10.1093","volume":"200","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5467-4663","authenticated-orcid":false,"given":"Sofia","family":"Caldeira-Dantas","sequence":"first","affiliation":[{"name":"Department of Immunology and Microbiology, Thomas Jefferson University , Philadelphia, PA 19107"},{"name":"Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho , 4710-057 Braga,","place":["Portugal"]},{"name":"Life and Health Sciences Research Institute (ICVS)\/3B\u2019s Associate Laboratory , 4710-057 Braga,","place":["Portugal"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3804-3861","authenticated-orcid":false,"given":"Thomas","family":"Furmanak","sequence":"additional","affiliation":[{"name":"Department of Immunology and Microbiology, Thomas Jefferson University , Philadelphia, PA 19107"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6548-9802","authenticated-orcid":false,"given":"Corinne","family":"Smith","sequence":"additional","affiliation":[{"name":"Department of Immunology and Microbiology, Thomas Jefferson University , Philadelphia, PA 19107"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Quinn","sequence":"additional","affiliation":[{"name":"Department of Immunology and Microbiology, Thomas Jefferson University , Philadelphia, PA 19107"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5854-6730","authenticated-orcid":false,"given":"Leyla Y","family":"Teos","sequence":"additional","affiliation":[{"name":"Sj\u00f6gren\u2019s Syndrome and Salivary Gland Dysfunction Unit, National Institute of Dental and Craniofacial Research, National Institutes of Health , Bethesda, MD 20892"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7455-1559","authenticated-orcid":false,"given":"Adam","family":"Ertel","sequence":"additional","affiliation":[{"name":"Department of Cancer Biology, Sidney Kimmel Cancer Center, Thomas Jefferson University , Philadelphia, PA 19107"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3959-7700","authenticated-orcid":false,"given":"Drishya","family":"Kurup","sequence":"additional","affiliation":[{"name":"Department of Immunology and Microbiology, Thomas Jefferson University , Philadelphia, PA 19107"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mayank","family":"Tandon","sequence":"additional","affiliation":[{"name":"Sj\u00f6gren\u2019s Syndrome and Salivary Gland Dysfunction Unit, National Institute of Dental and Craniofacial Research, National Institutes of Health , Bethesda, MD 20892"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilias","family":"Alevizos","sequence":"additional","affiliation":[{"name":"Sj\u00f6gren\u2019s Syndrome and Salivary Gland Dysfunction Unit, National Institute of Dental and Craniofacial Research, National Institutes of Health , Bethesda, MD 20892"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1370-7198","authenticated-orcid":false,"given":"Christopher M","family":"Snyder","sequence":"additional","affiliation":[{"name":"Department of Immunology and Microbiology, Thomas Jefferson University , Philadelphia, PA 19107"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2018,2,1]]},"reference":[{"key":"2025030610013945100_r1","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1186\/s12879-014-0569-1","article-title":"Repeated measures study of weekly and daily cytomegalovirus shedding patterns in saliva and urine of healthy cytomegalovirus-seropositive children","volume":"14","author":"Cannon","year":"2014","journal-title":"BMC Infect. 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