{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T12:33:17Z","timestamp":1775910797195,"version":"3.50.1"},"reference-count":51,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2018,5,1]],"date-time":"2018-05-01T00:00:00Z","timestamp":1525132800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,5,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The cytokine IFN-\u03b3 has well-established antibacterial properties against the bacterium Salmonella enterica in phagocytes, but less is known about the effects of IFN-\u03b3 on Salmonella-infected nonphagocytic cells, such as intestinal epithelial cells (IECs) and fibroblasts. In this article, we show that exposing human and murine IECs and fibroblasts to IFN-\u03b3 following infection with Salmonella triggers a novel form of cell death that is neither pyroptosis nor any of the major known forms of programmed cell death. Cell death required IFN-\u03b3-signaling via STAT1-IRF1\u2013mediated induction of guanylate binding proteins and the presence of live Salmonella in the cytosol. In vivo, ablating IFN-\u03b3 signaling selectively in murine IECs led to higher bacterial burden in colon contents and increased inflammation in the intestine of infected mice. Together, these results demonstrate that IFN-\u03b3 signaling triggers release of Salmonella from the Salmonella-containing vacuole into the cytosol of infected nonphagocytic cells, resulting in a form of nonpyroptotic cell death that prevents bacterial spread in the gut.<\/jats:p>","DOI":"10.4049\/jimmunol.1701386","type":"journal-article","created":{"date-parts":[[2018,4,13]],"date-time":"2018-04-13T18:39:33Z","timestamp":1523644773000},"page":"3626-3634","source":"Crossref","is-referenced-by-count":19,"title":["A Nonpyroptotic IFN-\u03b3\u2013Triggered Cell Death Mechanism in Nonphagocytic Cells Promotes <i>Salmonella<\/i> Clearance In Vivo"],"prefix":"10.1093","volume":"200","author":[{"given":"Justin P","family":"Ingram","sequence":"first","affiliation":[{"name":"Blood Cell Development and Function Program, Fox Chase Cancer Center , Philadelphia, PA 19111"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah","family":"Tursi","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Lewis Katz School of Medicine, Temple University , Philadelphia, PA 19140"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ting","family":"Zhang","sequence":"additional","affiliation":[{"name":"Blood Cell Development and Function Program, Fox Chase Cancer Center , Philadelphia, PA 19111"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Guo","sequence":"additional","affiliation":[{"name":"Cancer Prevention and Control Program, Fox Chase Cancer Center , Philadelphia, PA 19111"},{"name":"Department of General Surgery, Qilu Hospital of Shandong University , Jinan 250012,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chaoran","family":"Yin","sequence":"additional","affiliation":[{"name":"Blood Cell Development and Function Program, Fox Chase Cancer Center , Philadelphia, PA 19111"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meghan A","family":"Wynosky-Dolfi","sequence":"additional","affiliation":[{"name":"Department of Pathobiology, University of Pennsylvania School of Veterinary Medicine , Philadelphia, PA 19104"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joris","family":"van der Heijden","sequence":"additional","affiliation":[{"name":"Michael Smith Laboratories, University of British Columbia , Vancouver, British Columbia V6T1Z4,","place":["Canada"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathy Q","family":"Cai","sequence":"additional","affiliation":[{"name":"Cancer Biology Program, Fox Chase Cancer Center , Philadelphia, PA 19111"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masahiro","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Department of Immunoparasitology, Research Institute for Microbial Diseases, Osaka University Suita , Osaka 565-0871,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B Brett","family":"Finlay","sequence":"additional","affiliation":[{"name":"Michael Smith Laboratories, University of British Columbia , Vancouver, British Columbia V6T1Z4,","place":["Canada"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7970-872X","authenticated-orcid":false,"given":"Igor E","family":"Brodsky","sequence":"additional","affiliation":[{"name":"Department of Pathobiology, University of Pennsylvania School of Veterinary Medicine , Philadelphia, PA 19104"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sergei I","family":"Grivennikov","sequence":"additional","affiliation":[{"name":"Cancer Prevention and Control Program, Fox Chase Cancer Center , Philadelphia, PA 19111"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7073-0226","authenticated-orcid":false,"given":"\u00c7agla","family":"T\u00fckel","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Lewis Katz School of Medicine, Temple University , Philadelphia, PA 19140"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Siddharth","family":"Balachandran","sequence":"additional","affiliation":[{"name":"Blood Cell Development and Function Program, Fox Chase Cancer Center , Philadelphia, PA 19111"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2018,5,15]]},"reference":[{"key":"2025030610150056900_r1","doi-asserted-by":"crossref","first-page":"101","DOI":"10.2217\/fmb.14.98","article-title":"Protective host immune responses to Salmonella infection","volume":"10","author":"Pham","year":"2015","journal-title":"Future Microbiol."},{"key":"2025030610150056900_r2","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1016\/j.chom.2015.05.002","article-title":"Salmonella manipulation of host signaling pathways provokes cellular transformation associated with gallbladder carcinoma","volume":"17","author":"Scanu","year":"2015","journal-title":"Cell Host Microbe"},{"key":"2025030610150056900_r3","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1177\/2050640614558346","article-title":"Bacterial infections in childhood: a risk factor for gastrointestinal and other diseases?","volume":"3","author":"Schwille-Kiuntke","year":"2015","journal-title":"United European Gastroenterol. J."},{"key":"2025030610150056900_r4","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1016\/j.tim.2014.06.007","article-title":"Salmonella chronic carriage: epidemiology, diagnosis, and gallbladder persistence","volume":"22","author":"Gunn","year":"2014","journal-title":"Trends Microbiol."},{"key":"2025030610150056900_r5","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.yapd.2015.04.005","article-title":"Salmonella infections in childhood","volume":"62","author":"Bula-Rudas","year":"2015","journal-title":"Adv. Pediatr."},{"key":"2025030610150056900_r6","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1146\/annurev-micro-091313-103739","article-title":"Salmonella enterica serovar Typhi and the pathogenesis of typhoid fever","volume":"68","author":"Dougan","year":"2014","journal-title":"Annu. Rev. Microbiol."},{"key":"2025030610150056900_r7","doi-asserted-by":"crossref","first-page":"1770","DOI":"10.1056\/NEJMra020201","article-title":"Typhoid fever","volume":"347","author":"Parry","year":"2002","journal-title":"N. Engl. J. Med."},{"key":"2025030610150056900_r8","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1097\/MOG.0b013e3282f21388","article-title":"Pathogenesis of enteric Salmonella infections","volume":"24","author":"Grassl","year":"2008","journal-title":"Curr. Opin. Gastroenterol."},{"key":"2025030610150056900_r9","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1111\/j.1462-5822.2007.01090.x","article-title":"The Vi-capsule prevents Toll-like receptor 4 recognition of Salmonella","volume":"10","author":"Wilson","year":"2008","journal-title":"Cell. Microbiol."},{"key":"2025030610150056900_r10","doi-asserted-by":"crossref","first-page":"e1000538","DOI":"10.1371\/journal.ppat.1000538","article-title":"Salmonella Typhimurium type III secretion effectors stimulate innate immune responses in cultured epithelial cells","volume":"5","author":"Bruno","year":"2009","journal-title":"PLoS Pathog."},{"key":"2025030610150056900_r11","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/j.chom.2010.09.003","article-title":"A mouse model for the human pathogen Salmonella typhi","volume":"8","author":"Song","year":"2010","journal-title":"Cell Host Microbe"},{"key":"2025030610150056900_r12","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1038\/287440a0","article-title":"Control of natural resistance to Salmonella typhimurium and Leishmania donovani in mice by closely linked but distinct genetic loci","volume":"287","author":"O\u2019Brien","year":"1980","journal-title":"Nature"},{"key":"2025030610150056900_r13","doi-asserted-by":"crossref","first-page":"e1002933","DOI":"10.1371\/journal.ppat.1002933","article-title":"Host-pathogen interaction in invasive Salmonellosis","volume":"8","author":"de Jong","year":"2012","journal-title":"PLoS Pathog."},{"key":"2025030610150056900_r14","doi-asserted-by":"crossref","first-page":"1847","DOI":"10.1073\/pnas.89.5.1847","article-title":"Identification of a Salmonella typhimurium invasion locus by selection for hyperinvasive mutants","volume":"89","author":"Lee","year":"1992","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2025030610150056900_r15","doi-asserted-by":"crossref","first-page":"2635","DOI":"10.1128\/IAI.00077-09","article-title":"Salmonella enterica serovar typhimurium pathogenicity island 1-encoded type III secretion system translocases mediate intimate attachment to nonphagocytic cells","volume":"77","author":"Lara-Tejero","year":"2009","journal-title":"Infect. Immun."},{"key":"2025030610150056900_r16","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/S1286-4579(01)01411-3","article-title":"Salmonella pathogenicity islands encoding type III secretion systems","volume":"3","author":"Hansen-Wester","year":"2001","journal-title":"Microbes Infect."},{"key":"2025030610150056900_r17","doi-asserted-by":"crossref","first-page":"e1006354","DOI":"10.1371\/journal.ppat.1006354","article-title":"A second wave of Salmonella T3SS1 activity prolongs the lifespan of infected epithelial cells","volume":"13","author":"Finn","year":"2017","journal-title":"PLoS Pathog."},{"key":"2025030610150056900_r18","doi-asserted-by":"crossref","first-page":"3687","DOI":"10.1007\/s00018-011-0841-0","article-title":"Salmonella effector proteins and host-cell responses","volume":"68","author":"Srikanth","year":"2011","journal-title":"Cell. Mol. Life Sci."},{"key":"2025030610150056900_r19","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.chom.2014.11.011","article-title":"PLEKHM1 regulates Salmonella-containing vacuole biogenesis and infection","volume":"17","author":"McEwan","year":"2015","journal-title":"Cell Host Microbe"},{"key":"2025030610150056900_r20","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1038\/nature13157","article-title":"Caspase-11 activation requires lysis of pathogen-containing vacuoles by IFN-induced GTPases","volume":"509","author":"Meunier","year":"2014","journal-title":"Nature"},{"key":"2025030610150056900_r21","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1126\/science.1201711","article-title":"A family of IFN-\u03b3-inducible 65-kD GTPases protects against bacterial infection","volume":"332","author":"Kim","year":"2011","journal-title":"Science"},{"key":"2025030610150056900_r22","doi-asserted-by":"crossref","first-page":"1745","DOI":"10.1084\/jem.20100257","article-title":"Redundant roles for inflammasome receptors NLRP3 and NLRC4 in host defense against Salmonella","volume":"207","author":"Broz","year":"2010","journal-title":"J. Exp. Med."},{"key":"2025030610150056900_r23","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1038\/nature13683","article-title":"Inflammatory caspases are innate immune receptors for intracellular LPS","volume":"514","author":"Shi","year":"2014","journal-title":"Nature"},{"key":"2025030610150056900_r24","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1038\/nature15541","article-title":"Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling","volume":"526","author":"Kayagaki","year":"2015","journal-title":"Nature"},{"key":"2025030610150056900_r25","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1038\/nature15514","article-title":"Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death","volume":"526","author":"Shi","year":"2015","journal-title":"Nature"},{"key":"2025030610150056900_r26","doi-asserted-by":"crossref","first-page":"2927","DOI":"10.1002\/eji.201545772","article-title":"Caspase-11 activates a canonical NLRP3 inflammasome by promoting K(+) efflux","volume":"45","author":"R\u00fchl","year":"2015","journal-title":"Eur. J. Immunol."},{"key":"2025030610150056900_r27","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1016\/j.immuni.2017.03.016","article-title":"NAIP-NLRC4 inflammasomes coordinate intestinal epithelial cell expulsion with eicosanoid and IL-18 release via activation of caspase-1 and -8","volume":"46","author":"Rauch","year":"2017","journal-title":"Immunity"},{"key":"2025030610150056900_r28","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1038\/ni.2397","article-title":"Type I interferon induces necroptosis in macrophages during infection with Salmonella enterica serovar Typhimurium","volume":"13","author":"Robinson","year":"2012","journal-title":"Nat. Immunol."},{"key":"2025030610150056900_r29","doi-asserted-by":"crossref","first-page":"E3109","DOI":"10.1073\/pnas.1301218110","article-title":"Interferon-induced RIP1\/RIP3-mediated necrosis requires PKR and is licensed by FADD and caspases","volume":"110","author":"Thapa","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2025030610150056900_r30","doi-asserted-by":"crossref","first-page":"1464","DOI":"10.1128\/MCB.24.4.1464-1469.2004","article-title":"Kinase RIP3 is dispensable for normal NF-kappa Bs, signaling by the B-cell and T-cell receptors, tumor necrosis factor receptor 1, and Toll-like receptors 2 and 4","volume":"24","author":"Newton","year":"2004","journal-title":"Mol. Cell. Biol."},{"key":"2025030610150056900_r31","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1038\/nature06537","article-title":"TANK-binding kinase-1 delineates innate and adaptive immune responses to DNA vaccines","volume":"451","author":"Ishii","year":"2008","journal-title":"Nature"},{"key":"2025030610150056900_r32","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/j.immuni.2012.06.009","article-title":"A cluster of interferon-\u03b3-inducible p65 GTPases plays a critical role in host defense against Toxoplasma gondii","volume":"37","author":"Yamamoto","year":"2012","journal-title":"Immunity"},{"key":"2025030610150056900_r33","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/S0092-8674(00)81288-X","article-title":"Targeted disruption of the Stat1 gene in mice reveals unexpected physiologic specificity in the JAK-STAT signaling pathway","volume":"84","author":"Meraz","year":"1996","journal-title":"Cell"},{"key":"2025030610150056900_r34","first-page":"Unit 28.1","article-title":"Preparation, culture, and immortalization of mouse embryonic fibroblasts","volume":"Chapter 28","author":"Xu","year":"2005","journal-title":"Curr. Protoc. Mol. Biol."},{"key":"2025030610150056900_r35","doi-asserted-by":"crossref","first-page":"e1003414","DOI":"10.1371\/journal.ppat.1003414","article-title":"IRG and GBP host resistance factors target aberrant, \u201cnon-self\u201d vacuoles characterized by the missing of \u201cself\u201d IRGM proteins","volume":"9","author":"Haldar","year":"2013","journal-title":"PLoS Pathog."},{"key":"2025030610150056900_r36","doi-asserted-by":"crossref","first-page":"33275","DOI":"10.1074\/jbc.M204935200","article-title":"Cis elements of the villin gene control expression in restricted domains of the vertical (crypt) and horizontal (duodenum, cecum) axes of the intestine","volume":"277","author":"Madison","year":"2002","journal-title":"J. Biol. Chem."},{"key":"2025030610150056900_r37","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1046\/j.1462-5822.2001.00087.x","article-title":"SifA permits survival and replication of Salmonella typhimurium in murine macrophages","volume":"3","author":"Brumell","year":"2001","journal-title":"Cell. Microbiol."},{"key":"2025030610150056900_r38","doi-asserted-by":"crossref","first-page":"2901","DOI":"10.1128\/iai.59.9.2901-2908.1991","article-title":"Distribution of the invA, -B, -C, and -D genes of Salmonella typhimurium among other Salmonella serovars: invA mutants of Salmonella typhi are deficient for entry into mammalian cells","volume":"59","author":"Gal\u00e1n","year":"1991","journal-title":"Infect. Immun."},{"key":"2025030610150056900_r39","doi-asserted-by":"crossref","first-page":"2839","DOI":"10.1128\/IAI.71.5.2839-2858.2003","article-title":"Pretreatment of mice with streptomycin provides a Salmonella enterica serovar Typhimurium colitis model that allows analysis of both pathogen and host","volume":"71","author":"Barthel","year":"2003","journal-title":"Infect. Immun."},{"key":"2025030610150056900_r40","doi-asserted-by":"crossref","first-page":"e0157231","DOI":"10.1371\/journal.pone.0157231","article-title":"Rickettsia australis activates inflammasome in human and murine macrophages","volume":"11","author":"Smalley","year":"2016","journal-title":"PLoS One"},{"key":"2025030610150056900_r41","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1146\/annurev.biochem.67.1.227","article-title":"How cells respond to interferons","volume":"67","author":"Stark","year":"1998","journal-title":"Annu. Rev. Biochem."},{"key":"2025030610150056900_r42","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1016\/j.cell.2016.09.012","article-title":"IRGB10 liberates bacterial ligands for sensing by the AIM2 and caspase-11-NLRP3 inflammasomes","volume":"167","author":"Man","year":"2016","journal-title":"Cell"},{"key":"2025030610150056900_r43","doi-asserted-by":"crossref","first-page":"e115423","DOI":"10.1371\/journal.pone.0115423","article-title":"Live cell imaging reveals novel functions of Salmonella enterica SPI2-T3SS effector proteins in remodeling of the host cell endosomal system","volume":"9","author":"Rajashekar","year":"2014","journal-title":"PLoS One"},{"key":"2025030610150056900_r44","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1046\/j.1462-5822.2002.00170.x","article-title":"The invasion-associated type III secretion system of Salmonella enterica serovar Typhimurium is necessary for intracellular proliferation and vacuole biogenesis in epithelial cells","volume":"4","author":"Steele-Mortimer","year":"2002","journal-title":"Cell. Microbiol."},{"key":"2025030610150056900_r45","doi-asserted-by":"crossref","first-page":"2705","DOI":"10.1099\/00221287-148-9-2705","article-title":"Growth and killing of a Salmonella enterica serovar Typhimurium sifA mutant strain in the cytosol of different host cell lines","volume":"148","author":"Beuz\u00f3n","year":"2002","journal-title":"Microbiology"},{"key":"2025030610150056900_r46","doi-asserted-by":"crossref","first-page":"e29","DOI":"10.1371\/journal.ppat.0030029","article-title":"TBK1 protects vacuolar integrity during intracellular bacterial infection","volume":"3","author":"Radtke","year":"2007","journal-title":"PLoS Pathog."},{"key":"2025030610150056900_r47","doi-asserted-by":"crossref","first-page":"17733","DOI":"10.1073\/pnas.1006098107","article-title":"Dissemination of invasive Salmonella via bacterial-induced extrusion of mucosal epithelia","volume":"107","author":"Knodler","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2025030610150056900_r48","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1126\/science.1205405","article-title":"Phosphorylation of the autophagy receptor optineurin restricts Salmonella growth","volume":"333","author":"Wild","year":"2011","journal-title":"Science"},{"key":"2025030610150056900_r49","doi-asserted-by":"crossref","first-page":"e01006","DOI":"10.1128\/mBio.01006-14","article-title":"RIG-I detects mRNA of intracellular Salmonella enterica serovar Typhimurium during bacterial infection","volume":"5","author":"Schmolke","year":"2014","journal-title":"MBio"},{"key":"2025030610150056900_r50","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.chom.2014.07.002","article-title":"Noncanonical inflammasome activation of caspase-4\/caspase-11 mediates epithelial defenses against enteric bacterial pathogens","volume":"16","author":"Knodler","year":"2014","journal-title":"Cell Host Microbe"},{"key":"2025030610150056900_r51","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.chom.2014.07.001","article-title":"Epithelium-intrinsic NAIP\/NLRC4 inflammasome drives infected enterocyte expulsion to restrict Salmonella replication in the intestinal mucosa","volume":"16","author":"Sellin","year":"2014","journal-title":"Cell Host Microbe"}],"container-title":["The Journal of Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/200\/10\/3626\/62231845\/ji1701386.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/200\/10\/3626\/62231845\/ji1701386.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,6]],"date-time":"2025-03-06T10:44:35Z","timestamp":1741257875000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jimmunol\/article\/200\/10\/3626\/7966060"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,5]]},"references-count":51,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2018,5,15]]}},"URL":"https:\/\/doi.org\/10.4049\/jimmunol.1701386","relation":{},"ISSN":["0022-1767","1550-6606"],"issn-type":[{"value":"0022-1767","type":"print"},{"value":"1550-6606","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2018,5]]},"published":{"date-parts":[[2018,5]]}}}