{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T09:28:00Z","timestamp":1773221280643,"version":"3.50.1"},"reference-count":23,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2018,4,1]],"date-time":"2018-04-01T00:00:00Z","timestamp":1522540800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The complement system is a sophisticated network of proteases. In this article, we describe an unexpected link between two linear activation routes of the complement system: the lectin pathway (LP) and the alternative pathway (AP). Mannose-lectin binding\u2013associated serine protease (MASP)-1 is known to be the initiator protease of the LP. Using a specific and potent inhibitor of MASP-1, SGMI-1, as well as other MASP-1 inhibitors with different mechanisms of action, we demonstrated that, in addition to its functions in the LP, MASP-1 is essential for bacterial LPS-induced AP activation, whereas it has little effect on zymosan-induced AP activation. We have shown that MASP-1 inhibition prevents AP activation, as well as attenuates the already initiated AP activity on the LPS surface. This newly recognized function of MASP-1 can be important for the defense against certain bacterial infections. Our results also emphasize that the mechanism of AP activation depends on the activator surface.<\/jats:p>","DOI":"10.4049\/jimmunol.1701421","type":"journal-article","created":{"date-parts":[[2018,2,23]],"date-time":"2018-02-23T15:50:46Z","timestamp":1519401046000},"page":"2247-2252","source":"Crossref","is-referenced-by-count":20,"title":["Cutting Edge: A New Player in the Alternative Complement Pathway, MASP-1 Is Essential for LPS-Induced, but Not for Zymosan-Induced, Alternative Pathway Activation"],"prefix":"10.1093","volume":"200","author":[{"given":"Katalin","family":"Par\u00e9j","sequence":"first","affiliation":[{"name":"Institute of Enzymology, Research Centre for Natural Sciences, Hungarian Academy of Sciences , H-1117 Budapest,","place":["Hungary"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9628-1796","authenticated-orcid":false,"given":"Andrea","family":"Kocsis","sequence":"additional","affiliation":[{"name":"Institute of Enzymology, Research Centre for Natural Sciences, Hungarian Academy of Sciences , H-1117 Budapest,","place":["Hungary"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Csenge","family":"Enyingi","sequence":"additional","affiliation":[{"name":"Institute of Enzymology, Research Centre for Natural Sciences, Hungarian Academy of Sciences , H-1117 Budapest,","place":["Hungary"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R\u00e1hel","family":"Dani","sequence":"additional","affiliation":[{"name":"Institute of Enzymology, Research Centre for Natural Sciences, Hungarian Academy of Sciences , H-1117 Budapest,","place":["Hungary"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3798-9097","authenticated-orcid":false,"given":"G\u00e1bor","family":"Oroszl\u00e1n","sequence":"additional","affiliation":[{"name":"Institute of Enzymology, Research Centre for Natural Sciences, Hungarian Academy of Sciences , H-1117 Budapest,","place":["Hungary"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L\u00e1szl\u00f3","family":"Beinrohr","sequence":"additional","affiliation":[{"name":"Institute of Enzymology, Research Centre for Natural Sciences, Hungarian Academy of Sciences , H-1117 Budapest,","place":["Hungary"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00f3zsef","family":"Dob\u00f3","sequence":"additional","affiliation":[{"name":"Institute of Enzymology, Research Centre for Natural Sciences, Hungarian Academy of Sciences , H-1117 Budapest,","place":["Hungary"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P\u00e9ter","family":"Z\u00e1vodszky","sequence":"additional","affiliation":[{"name":"Institute of Enzymology, Research Centre for Natural Sciences, Hungarian Academy of Sciences , H-1117 Budapest,","place":["Hungary"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G\u00e1bor","family":"P\u00e1l","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, E\u00f6tv\u00f6s Lor\u00e1nd University , H-1117 Budapest,","place":["Hungary"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P\u00e9ter","family":"G\u00e1l","sequence":"additional","affiliation":[{"name":"Institute of Enzymology, Research Centre for Natural Sciences, Hungarian Academy of Sciences , H-1117 Budapest,","place":["Hungary"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2018,4,1]]},"reference":[{"key":"2025030610142059700_r1","doi-asserted-by":"crossref","first-page":"10498","DOI":"10.1073\/pnas.1202588109","article-title":"Revised mechanism of complement lectin-pathway activation revealing the role of serine protease MASP-1 as the exclusive activator of MASP-2","volume":"109","author":"H\u00e9ja","year":"2012","journal-title":"Proc. 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