{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T05:56:38Z","timestamp":1790402198031,"version":"4.1.0"},"reference-count":54,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2018,3,1]],"date-time":"2018-03-01T00:00:00Z","timestamp":1519862400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Mucosal-associated invariant T (MAIT) cells produce inflammatory cytokines and cytotoxic granzymes in response to by-products of microbial riboflavin synthesis. Although MAIT cells are protective against some pathogens, we reasoned that they might contribute to pathology in chronic bacterial infection. We observed MAIT cells in proximity to Helicobacter pylori bacteria in human gastric tissue, and so, using MR1-tetramers, we examined whether MAIT cells contribute to chronic gastritis in a mouse H. pylori SS1 infection model. Following infection, MAIT cells accumulated to high numbers in the gastric mucosa of wild-type C57BL\/6 mice, and this was even more pronounced in MAIT TCR transgenic mice or in C57BL\/6 mice where MAIT cells were preprimed by Ag exposure or prior infection. Gastric MAIT cells possessed an effector memory Tc1\/Tc17 phenotype, and were associated with accelerated gastritis characterized by augmented recruitment of neutrophils, macrophages, dendritic cells, eosinophils, and non-MAIT T cells and by marked gastric atrophy. Similarly treated MR1\u2212\/\u2212 mice, which lack MAIT cells, showed significantly less gastric pathology. Thus, we demonstrate the pathogenic potential of MAIT cells in Helicobacter-associated immunopathology, with implications for other chronic bacterial infections.<\/jats:p>","DOI":"10.4049\/jimmunol.1701512","type":"journal-article","created":{"date-parts":[[2018,1,29]],"date-time":"2018-01-29T14:30:18Z","timestamp":1517236218000},"page":"1901-1916","source":"Crossref","is-referenced-by-count":75,"title":["Mucosal-Associated Invariant T Cells Augment Immunopathology and Gastritis in Chronic\n                    <i>Helicobacter pylori<\/i>\n                    Infection"],"prefix":"10.1093","volume":"200","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2257-6388","authenticated-orcid":false,"given":"Criselle","family":"D\u2019Souza","sequence":"first","affiliation":[{"name":"Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, The University of Melbourne , Melbourne, Victoria 3000,","place":["Australia"]},{"name":"Centre for Animal Biotechnology, Faculty of Veterinary and Agricultural Sciences, The University of Melbourne , Victoria 3010,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Troi","family":"Pediongco","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, The University of Melbourne , Melbourne, Victoria 3000,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0226-3982","authenticated-orcid":false,"given":"Huimeng","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, The University of Melbourne , Melbourne, Victoria 3000,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8385-353X","authenticated-orcid":false,"given":"Jean-Pierre Y","family":"Scheerlinck","sequence":"additional","affiliation":[{"name":"Centre for Animal Biotechnology, Faculty of Veterinary and Agricultural Sciences, The University of Melbourne , Victoria 3010,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lyudmila","family":"Kostenko","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, The University of Melbourne , Melbourne, Victoria 3000,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7091-0048","authenticated-orcid":false,"given":"Robyn","family":"Esterbauer","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, The University of Melbourne , Melbourne, Victoria 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S","family":"Meehan","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, The University of Melbourne , Melbourne, Victoria 3000,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard A","family":"Strugnell","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, The University of Melbourne , Melbourne, Victoria 3000,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanwei","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, The University of Melbourne , Melbourne, Victoria 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Centre of Excellence in Advanced Molecular Imaging, The University of Queensland , Brisbane, Queensland 4072,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"Lovrecz","sequence":"additional","affiliation":[{"name":"BioMedical Manufacturing, Commonwealth Scientific and Industrial Research Organisation , Melbourne, Victoria 3052,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louis","family":"Lu","sequence":"additional","affiliation":[{"name":"BioMedical Manufacturing, Commonwealth Scientific and Industrial Research Organisation , Melbourne, Victoria 3052,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David P","family":"Fairlie","sequence":"additional","affiliation":[{"name":"Division of Chemistry and Structural Biology, Institute for Molecular Bioscience, The University of Queensland , Brisbane, Queensland 4072,","place":["Australia"]},{"name":"Australian Research Council Centre of Excellence in Advanced Molecular Imaging, The University of Queensland , Brisbane, Queensland 4072,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jamie","family":"Rossjohn","sequence":"additional","affiliation":[{"name":"Infection and Immunity Program, Biomedicine Discovery Institute, Monash University , Clayton, Victoria 3800,","place":["Australia"]},{"name":"Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University , Clayton, Victoria 3800,","place":["Australia"]},{"name":"Australian Research Council Centre of Excellence in Advanced Molecular Imaging, Monash University , Clayton, Victoria 3800,","place":["Australia"]},{"name":"Institute of Infection and Immunity, Cardiff University School of Medicine , Cardiff CF14 4XN,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8597-815X","authenticated-orcid":false,"given":"James","family":"McCluskey","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, The University of Melbourne , Melbourne, Victoria 3000,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8275-4292","authenticated-orcid":false,"given":"Alison L","family":"Every","sequence":"additional","affiliation":[{"name":"Centre for Animal Biotechnology, Faculty of Veterinary and Agricultural Sciences, The University of Melbourne , Victoria 3010,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenjun","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Peter Doherty Institute for Infection and 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