{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T18:24:15Z","timestamp":1770488655247,"version":"3.49.0"},"reference-count":50,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2018,6,1]],"date-time":"2018-06-01T00:00:00Z","timestamp":1527811200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,6,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Recent evidence suggests early environmental factors are important for gut immune tolerance. Although the role of regulatory T (Treg) cells for gut immune homeostasis is well established, the development and tissue homing characteristics of Treg cells in children have not been studied in detail. In this article, we studied the development and homing characteristics of human peripheral blood Treg cell subsets and potential mechanisms inducing homing molecule expression in healthy children. We found contrasting patterns of circulating Treg cell gut and skin tropism, with abundant \u03b27 integrin+ Treg cells at birth and increasing cutaneous lymphocyte Ag (CLA+) Treg cells later in life. \u03b27 integrin+ Treg cells were predominantly naive, suggesting acquisition of Treg cell gut tropism early in development. In vitro, IL-7 enhanced gut homing but reduced skin homing molecule expression in conventional T cells, whereas IL-2 induced a similar effect only in Treg cells. This effect was more pronounced in cord compared with adult blood. Our results suggest that early in life, naive Treg cells may be driven for gut tropism by their increased sensitivity to IL-2\u2013induced \u03b27 integrin upregulation, implicating a potential role of IL-2 in gut immune tolerance during this critical period of development.<\/jats:p>","DOI":"10.4049\/jimmunol.1701533","type":"journal-article","created":{"date-parts":[[2018,5,2]],"date-time":"2018-05-02T15:40:13Z","timestamp":1525275613000},"page":"3970-3980","source":"Crossref","is-referenced-by-count":19,"title":["IL-2 Enhances Gut Homing Potential of Human Naive Regulatory T Cells Early in Life"],"prefix":"10.1093","volume":"200","author":[{"given":"Peter S","family":"Hsu","sequence":"first","affiliation":[{"name":"Department of Allergy and Immunology, The Children\u2019s Hospital at Westmead , Sydney, New South Wales 2145,","place":["Australia"]},{"name":"Kids Research Institute, The Children\u2019s Hospital at Westmead , Sydney, New South Wales 2145,","place":["Australia"]},{"name":"Discipline of Paediatrics and Child Health, The University of Sydney , Sydney, New South Wales 2145,","place":["Australia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4076-0464","authenticated-orcid":false,"given":"Catherine L","family":"Lai","sequence":"additional","affiliation":[{"name":"Department of Allergy and Immunology, The Children\u2019s Hospital at Westmead , Sydney, New South Wales 2145,","place":["Australia"]},{"name":"Kids Research Institute, The Children\u2019s Hospital at Westmead , Sydney, New South Wales 2145,","place":["Australia"]},{"name":"Charles Perkins Centre Nepean , Nepean, New South Wales 2747,","place":["Australia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0104-2072","authenticated-orcid":false,"given":"Mingjing","family":"Hu","sequence":"additional","affiliation":[{"name":"Charles Perkins Centre Nepean , Nepean, New South Wales 2747,","place":["Australia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brigitte","family":"Santner-Nanan","sequence":"additional","affiliation":[{"name":"Charles Perkins Centre Nepean , Nepean, New South Wales 2747,","place":["Australia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jane E","family":"Dahlstrom","sequence":"additional","affiliation":[{"name":"Department of Anatomical Pathology, Australian Capital Territory Pathology, Canberra Hospital , Garran, Australian Capital Territory 2605,","place":["Australia"]},{"name":"Australian National University Medical School , Canberra, Australian Capital Territory 0200,","place":["Australia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1025-6520","authenticated-orcid":false,"given":"Cheng Hiang","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, The Children\u2019s Hospital at Westmead , Sydney, New South Wales 2145,","place":["Australia"]},{"name":"James Fairfax Institute of Paediatric Nutrition, The University of Sydney , Sydney, New South Wales 2006,","place":["Australia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ayesha","family":"Ajmal","sequence":"additional","affiliation":[{"name":"Department of Anatomical Pathology, Australian Capital Territory Pathology, Canberra Hospital , Garran, Australian Capital Territory 2605,","place":["Australia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amanda","family":"Bullman","sequence":"additional","affiliation":[{"name":"Department of Anatomical Pathology, Australian Capital Territory Pathology, Canberra Hospital , Garran, Australian Capital Territory 2605,","place":["Australia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susan","family":"Arbuckle","sequence":"additional","affiliation":[{"name":"Department of Pathology, The Children\u2019s Hospital at Westmead , Sydney, New South Wales 2145,","place":["Australia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2479-5317","authenticated-orcid":false,"given":"Ahmed","family":"Al Saedi","sequence":"additional","affiliation":[{"name":"Charles Perkins Centre Nepean , Nepean, New South Wales 2747,","place":["Australia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lou","family":"Gacis","sequence":"additional","affiliation":[{"name":"Department of Allergy and Immunology, The Children\u2019s Hospital at Westmead , Sydney, New South Wales 2145,","place":["Australia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7493-4055","authenticated-orcid":false,"given":"Reta","family":"Nambiar","sequence":"additional","affiliation":[{"name":"Department of Allergy and Immunology, The Children\u2019s Hospital at Westmead , Sydney, New South Wales 2145,","place":["Australia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew","family":"Williams","sequence":"additional","affiliation":[{"name":"Department of Allergy and Immunology, The Children\u2019s Hospital at Westmead , Sydney, New South Wales 2145,","place":["Australia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melanie","family":"Wong","sequence":"additional","affiliation":[{"name":"Department of Allergy and Immunology, The Children\u2019s Hospital at Westmead , Sydney, New South Wales 2145,","place":["Australia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dianne E","family":"Campbell","sequence":"additional","affiliation":[{"name":"Department of Allergy and Immunology, The Children\u2019s Hospital at Westmead , Sydney, New South Wales 2145,","place":["Australia"]},{"name":"Kids Research Institute, The Children\u2019s Hospital at Westmead , Sydney, New South Wales 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